Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 3, 2010, Pages 1140-1145

  Haenni, Marisa ^a   Galofaro, Laure ^a   Ythier, Mathilde ^b   Giddey, Marlyse ^b   Majcherczyk, Paul ^b   Moreillon, Philippe ^b   Madec, Jean Yves ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 1A; PENICILLIN BINDING PROTEIN 2B; PENICILLIN BINDING PROTEIN 2X; PENICILLIN G; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CATTLE DISEASE; DRUG SENSITIVITY; ECOLOGICAL NICHE; FRANCE; GENE MUTATION; MOLECULAR MECHANICS; NETHERLANDS; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIN RESISTANCE; PRIORITY JOURNAL; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS UBERIS; SWITZERLAND;

ANIMALS; CATTLE; CATTLE DISEASES; FEMALE; HUMANS; MASTITIS, BOVINE; MICROBIAL SENSITIVITY TESTS; MUTATION; PENICILLIN RESISTANCE; PENICILLIN-BINDING PROTEINS; PENICILLINS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS;

EID: 77149169704     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00915-09     Document Type: Article

References (27)

1. Amsterdam, D. 1996. Susceptibility testing of antimicrobials in liquid medium. In V. Lorian (ed.), Antibiotics in laboratory medicine, 4th ed. Williams & Wilkins, Baltimore, MD.
2. Botrel, M.-A., M. Haenni, E. Morignat, P. Sulpice, J.-Y. Madec, and D. Calavas. Distribution and antimicrobial resistance of clinical and subclinical mastitis pathogens in dairy cows in Rhône-Alpes, France. Foodborne Pathog. Dis., in press.
3. Bradley, A. J., K. A. Leach, J. E. Breen, L. E. Green, and M. J. Green. 2007. Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales. Vet. Rec. 160:253-258.
4. Dahesh, S., M. E. Hensler, N. M. Van Sorge, R. E. Gertz, Jr., S. Schrag, V. Nizet, and B. W. Beall. 2008. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob. Agents Chemother. 52:2915-2918.
5. Denapaite, D., F. Chi, P. Maurer, O. Nolte, and R. Hakenbeck. 2007. Mechanism of penicillin resistance in Streptococcus pneumoniae: targets, gene transfer, and mutations, p. 290-303. In R. Hakenbeck and G. S. Chhatwal (ed.), Molecular biology of streptococci. Horizon Biosciences, Wymondham, Norfolk, United Kingdom.
6. Dias, R., D. Felix, and M. Canica. 2008. Diversity of penicillin binding proteins among clinical Streptococcus pneumoniae strains from Portugal. Antimicrob. Agents Chemother. 52:2693-2695.
7. Entenza, J. M., J. Vouillamoz, M. P. Glauser, and P. Moreillon. 1997. Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 41:1662-1667.
8. Filipe, S. R., E. Severina, and A. Tomasz. 2002. The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. U. S. A. 99:1550-1555.
9. Guenzi, E., A. M. Gasc, M. A. Sicard, and R. Hakenbeck. 1994. A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol. Microbiol. 12:505-515.
10. Guerin-Faublee, V., F. Tardy, C. Bouveron, and G. Carret. 2002. Antimicrobial susceptibility of Streptococcus species isolated from clinical mastitis in dairy cows. Int. J. Antimicrob. Agents 19:219-226.
11. Gutmann, L., and A. Tomasz. 1982. Penicillin-resistant and penicillin-tolerant mutants of group A streptococci. Antimicrob. Agents Chemother. 22: 128-136.
12. Haenni, M., P. A. Majcherczyk, J. L. Barblan, and P. Moreillon. 2006. Mutational analysis of class A and class B penicillin-binding proteins in Streptococcus gordonii. Antimicrob. Agents Chemother. 50:4062-4069.
13. Haenni, M., and P. Moreillon. 2006. Mutations in penicillin-binding protein (PBP) genes and in non-PBP genes during selection of penicillin-resistant Streptococcus gordonii. Antimicrob. Agents Chemother. 50:4053-4061.
14. Hakenbeck, R., T. Grebe, D. Zahner, and J. B. Stock. 1999. Beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins. Mol. Microbiol. 33:673-678.
15. Hoban, D., F. Baquero, V. Reed, and D. Felmingham. 2005. Demographic analysis of antimicrobial resistance among Streptococcus pneumoniae: worldwide results from PROTEKT 1999-2000. Int. J. Infect. Dis. 9:262-273.
16. Izdebski, R., J. Rutschmann, J. Fiett, E. Sadowy, M. Gniadkowski, W. Hryniewicz, and R. Hakenbeck. 2008. Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland23F-16 and Poland6B-20. Antimicrob. Agents Chemother. 52:1021-1027.
17. Kimura, K., S. Suzuki, J.-I. Wachino, H. Kurokawa, K. Yamane, N. Shibata, N. Nagano, H. Kato, K. Shibayama, and Y. Arakawa. 2008. First molecular characterization of group B streptococci with reduced penicillin susceptibility. Antimicrob. Agents Chemother. 52:2890-2897.
18. Levy, C. S., P. Kogulan, V. J. Gill, M. B. Croxton, J. G. Kane, and D. R. Lucey. 2001. Endocarditis caused by penicillin-resistant viridans streptococci: 2 cases and controversies in therapy. Clin. Infect. Dis. 33:577-579.
19. Mouz, N., A. M. Di Guilmi, E. Gordon, R. Hakenbeck, O. Dideberg, and T. Vernet. 1999. Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics. J. Biol. Chem. 274:19175-19180.
20. Nagai, K., T. A. Davies, M. R. Jacobs, and P. C. Appelbaum. 2002. Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob. Agents Chemother. 46: 1273-1280.
21. Nagano, N., Y. Nagano, K. Kimura, K. Tamai, H. Yanagisawa, and Y. Arakawa. 2008. Genetic heterogeneity in pbp genes among clinically isolated group B streptococci with reduced penicillin susceptibility. Antimicrob. Agents Chemother. 52:4258-4267.
22. Perez-Trallero, E., C. Fernandez-Mazarrasa, C. Garcia-Rey, E. Bouza, L. Aguilar, J. Garcia-de-Lomas, and F. Baquero. 2001. Antimicrobial susceptibilities of 1,684 Streptococcus pneumoniae and 2,039 Streptococcus pyogenes isolates and their ecological relationships: results of a 1-year (1998-1999) multicenter surveillance study in Spain. Antimicrob. Agents Chemother. 45:3334-3340.
23. Pernot, L., L. Chesnel, A. Le Gouellec, J. Croize, T. Vernet, O. Dideberg, and A. Dessen. 2004. A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics. J. Biol. Chem. 279:16463-16470.
24. Rossitto, P. V., L. Ruiz, Y. Kikuchi, K. Glenn, K. Luiz, J. L. Watts, and J. S. Cullor. 2002. Antibiotic susceptibility patterns for environmental streptococci isolated from bovine mastitis in central California dairies. J. Dairy Sci. 85:132-138.
25. Sambrook, J., E. J. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
26. Tuohy, M., and J. A. Washington. 1997. Antimicrobial susceptibility of viridans group streptococci. Diagn. Microbiol. Infect. Dis. 29:277-280.
27. Ward, P., M. Holden, J. Leigh, N. Lennard, A. Bignell, A. Barron, L. Clark, M. Quail, J. Woodward, B. Barrell, S. Egan, T. Field, D. Maskell, M. Kehoe, C. Dowson, N. Chanter, A. Whatmore, S. Bentley, and J. Parkhill. 2009. Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis. BMC Genomics 10:54.