Protection of retinal vasculature by losartan against apoptosis and vasculopathy in rats with spontaneous hypertension

Journal of Hypertension

Volumn 28, Issue 3, 2010, Pages 510-519

  Yang, Deye ^a   Zhang, Mingying ^a   Huang, Xiaoyan ^a   Fang, Fei ^a   Chen, Bixin ^a   Wang, Saibin ^a   Cai, Jianqiu ^a   Shi, Xiangxiang ^a   Qu, Jia ^a   Geng, Yong Jian ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Angiotensin receptor antagonist; Apoptosis; Hypertension; Retinal capillary

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; EOSIN; HEMATOXYLIN; LOSARTAN POTASSIUM; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL INJURY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; EYE FUNDUS; HYPERTENSION RETINOPATHY; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; NICK END LABELING; NONHUMAN; PERICYTE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RETINA BLOOD VESSEL; SPONTANEOUSLY HYPERTENSIVE RAT; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION; VASCULAR DISEASE; WISTAR KYOTO RAT;

EID: 77149139148     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328333663f     Document Type: Article

References (27)

1. Greenberg SM. Small vessels, big problems. N Engl J Med 2006; 354:1451-1453.
2. Lin LY, Lin CY, Su TC, Liau CS. Angiotensin II-induced apoptosis in human endothelial cells is inhibited by adiponectin through restoration of the association between endothelial nitric oxide synthase and heat shock protein 90. FEBS Lett 2004; 574 (1-3):106-110.
3. Alford AC, Rajabi M, Taffet GE, Geng YJ. Apoptosis and stiffness of the arteries of mice prone to atherosclerosis. J Am Geriatr Soc 2004; 52:S8.
4. Li HW, Gao YX, Grobe JL, Raizada MK, Katovich MJ, Sumners C. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. Am J Heart Circ Physiol 2007; 292:H727-H735.
5. Touyz RM, Wu XH, He G, Salomon S, Schiffrin EL. Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased C-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension 2002; 39 (2 Pt 2):479-485.
6. Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol 2005; 38:175-184.
7. Fortuno MA, Ravassa S, Etayo JC, Diez J. Overexpression of bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: effects of AT1 blockade with losartan. Hypertension 1998; 32:280-286.
8. Goodfriend TL, Elliott ME, Catt KJ. Drug therapy: angiotensin receptors and their antagonists. N Engl J Med 1996; 334:1649-1654.
9. Li D, Tomson K, Yang B, Mehta P, Croker BP, Mehta JL. Modulation of constitutive nitro oxide synthase. Bcl-2 and Fas expression in cultured human coronary and endothelial cells exposed anoxia-reoxigenation and angiotension II: role of AT1 receptor activation. Cardivasc Res 1999; 41:109-115.
10. Li DY, Yang BC, Philips MI, Mehtaj L. Proapoptotic effect of ANG-II in human coronary artery endothelial cells: role of AT1 receptor and PKC activation. Am J Physiol 1999; 276 (3 Pt 2):H786-H792.
11. Kang PM, Landu AJ, Eberhardt RT, Frishman WH. Angiotensin II receptor antagonists: a new approach to blockade of the rennin-angiotensin system. Am Heart J 1994; 127:1388-1401.
12. Sone M, Itoh H, Yamashita J, Yurugi-Kobayashi T, Suzuki Y, Kondo Y, et al. Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells. Circulation 2003; 107:2085-2088. (Pubitemid 36532188)
13. Majumder S, Tamilarasan KP, Kolluru GK, Muley A, Nair CM, Omanakuttan A, et al. Activated pericyte attenuates endothelial functions: nitric oxide-cGMP rescues activated pericyte-associated endothelial dysfunctions. Biochem Cell Biol 2007; 85:709-720.
14. Nehls V, Drenckhahn D. The versatility of microvascular pericytes: from mesenchyme to smooth muscle. Histochemistry 1993; 99:1-12.
15. Reddy K, Zhou Z, Schadler K, Jia SF, Kleinerman ES. Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels. Mol Cancer Res 2008; 6:929-936.
16. David ES. The pericyte: a review. Tissue Cell 1986; 18:153-174.
17. Anderson DR, Davis EB. Glaucoma, capillaries and pericytes 5. Preliminary evidence that carbon dioxide relaxes pericyte contractile tone. Ophthalmologica 1996; 210:280-284.
18. Boise LH, Gonzalez-Garcia M, Postema CE, Ding LY, Lindsten T, Turka LA, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74:597-608.
19. Oltvai AN, Milliman CL, Korsmeyer SL. Bcl-2 heterodimerizes in vivo with a conserved homolog, bas, that accelerates programmed cell death. Cell 1993; 74:609-619.
20. Vila-Petroff M, Salas MA, Said M, Valverde CA, Sapia L, Portiansky E, et al. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovasc Res 2007; 73:689-698.
21. Yamada T, Horiuchi M, Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996; 93:156-160.
22. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998; 396:580-584.
23. Cigola E, Kajstura J, Li B, Meggs LG, Anversa P. Angiotensin II activates programmed myocyte cell death in vitro. Exp Cell Res 1997; 231:363-371.
24. Bascands JL, Girolami JP, Troly M, Escargueil-Blanc I, Nazzal D, Salvayreet R, et al. Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells. Hypertension 2001; 38:1294-1299.
25. Nakamura M, Tanaka M, Abe S, Fujiwara H. Sudden pressure elevation can trigger acute muscle cell death of the heart and aorta. Atherosclerosis 1999; 146:25-32.
26. Pollman MJ, Yamada T, Horiuchi M, Gibbons GH. Vasoactive substances regulate vascular smooth muscle cell apoptosis: countervailing influences of nitric oxide and angiotensin II. Circ Res 1996; 79:748-756.
27. Bhaskaran M, Reddy K, Radhakrishnan N, Franki N, Ding G, Singhal PC. Angiotensin II induces apoptosis in renal proximal tubular cells. Am J Physiol Renal Physiol 2003; 284:F955-F965.