Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes

BJU International

Volumn 105, Issue 5, 2010, Pages 674-680

  Chiou, Wen Fei ^a,b   Liu, Hui Kang ^a   Juan, Chi Wen ^c,d  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL TAITUNG UNIVERSITY   (Taiwan)

^c SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^d HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

CGMP dependent protein kinase G; Erectile dysfunction; Nitric oxide synthase; RhoA ROCK; Type 2 diabetes

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DYSLIPIDEMIA; ERECTILE DYSFUNCTION; HYPERGLYCEMIA; INTRACRANIAL PRESSURE; LIPID DIET; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ERECTILE DYSFUNCTION; MALE; NITRIC OXIDE SYNTHASE; PENILE ERECTION; PENIS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES;

EID: 77149131220     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2009.08852.x     Document Type: Article

References (24)

1. Rajfer J. Discovery of NO in the penis. Int J Impot Res 2008 20 : 431 436
2. Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci (Lond) 2006 110 : 153 165
3. Bivalacqua TJ, Champion HC, Usta MF et al. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2004 101 : 9121 9126
4. Khan ZA, Chakrabarti S. Endothelins in chronic diabetic complications. Can J Physiol Pharmacol 2003 81 : 622 634
5. Soh J, Katsuyama M, Ushijima S et al. Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: implications for erectile dysfunction. Urology 2007 70 : 1019 1023
6. Bivalacqua TJ, Kendirci M, Champion HC, Hellstrom WJG, Andersson KE, Hedlund P. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1. Br J Urol 2007 99 : 1488 1494
7. Bozkurt NB, Pekiner C. Impairment of endothelium- and nerve-mediated relaxation responses in the cavernosal smooth muscle of experimentally diabetic rabbits: role of weight loss and duration of diabetes. Naunyn Schmiedebergs Arch Pharmacol 2006 373 : 71 8
8. Chang S, Hypolite JA, Velez M et al. Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits. Am J Physiol Regul Integr Comp Physiol 2004 287 : R950 60
9. Podlasek CA, Zelner DJ, Bervig TR, Gonzalez CM, Mckenna KE, Mcvary KT. Characterization and localization of nitric oxide synthase isoforms in the BB/WOR diabetic rat. J Urol 2001 166 : 746 755
10. Jesmin S, Sakuma I, Salah-eldin A, Nonomura K, Hattori Y, Kitabatake A. Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. J Mol Endocrinol 2003 31 : 401 418
11. Srinivasan K, Patole PS, Kaul CL, Ramarao P. Reversal of glucose intolerance by pioglitazone in high-fat diet fed rats. Methods Find Exp Clin Pharmacol 2004 26 : 327 333
12. Zhang F, Ye C, Li G et al. The rat model of type 2 diabetes mellitus and its glycometabolism characters. Exp Anim 2003 52 : 401 407
13. Shabsigh R, Arver S, Channer KS et al. The triad of erectile dysfunction, hypogonadism and the metabolic syndrome. Int J Clin Pract 2008 62 : 791 8
14. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989 320 : 1025 1030
15. dp (type II) Rats with erectile dysfunction. Endocrinology 1995 136 : 5709 5717
16. Suetomi T, Hisasue S, Sato Y, Tabata Y, Akaza H, Tsukamoto T. Effect of basic fibroblast growth factor incorporating gelatin microspheres on erectile function in the diabetic rat. J Urol 2005 173 : 1423 1428
17. Hurdag C, Ozkara H, Citci S, Uyaner I, Demirci C. The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. Int J Tissue React 2005 27 : 145 150
18. Lincoln TM, Dey N, Sellak H. cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 2001 91 : 1421 1430
19. Zhang XH, Filippi S, Morelli A et al. Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. J Sex Med 2006 3 : 253 256
20. Aspenström P, Ruusala A, Pacholsky D. Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases. Exp Cell Res 2007 313 : 3673 3679
21. Chitaley K, Wingard CJ, Clinton Webb R et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001 7 : 119 122
22. Saenz de Tejada I, Carson MP, de las Morenas A, Goldstein I, Traish AM. Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum. Am J Physiol 1991 261 : H1078 85
23. Chang S, Hypolite JA, Changolkar A, Wein AJ, Chacko S, DiSanto ME. Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta. Int J Impot Res 2003 15 : 53 62
24. Christ GJ, Lerner SE, Kim DC, Melman A. Endothelin-1 as a putative modulator of erectile dysfunction. I. Characteristics of contraction of isolated corporal tissue strips. J Urol 1995 153 : 1998 2003