Discovery of NO in the penis

International Journal of Impotence Research

Volumn 20, Issue 5, 2008, Pages 431-436

  Rajfer, J ^a,b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cyclic GMP; Erectile dysfunction; Nitric oxide; Viagra

Indexed keywords

NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; ZAPRINAST;

CLINICAL PRACTICE; CLINICAL RESEARCH; DRUG EFFECT; ERECTILE DYSFUNCTION; HUMAN; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; REVIEW;

ANIMALS; CALCIUM; HUMANS; MALE; MEMBRANE PROTEINS; NITRIC OXIDE; NUCLEOTIDES, CYCLIC; PENIS;

EID: 51849142357     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2008.10     Document Type: Review

References (20)

1. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil study group. N Engl J Med 1998; 338: 1397-1404.
2. Arndt M. Is Viagra vulnerable? Business Week 2003, (www.businessweek.com/magazine/content/03_43/b3855120.htm).
3. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326: 90-94.
4. Lue TF, Takamura T, Schmidt RA, Palubinskas AJ, Tanagho EA. Hemodynamics of erection in the monkey. J Urol 1983; 130: 1237-1241.
5. Fournier Jr GR, Juenemann KP, Lue TF, Tanagho EA. Mechanisms of venous occlusion during canine penile erection: an anatomic demonstration. J Urol 1987; 137: 163-167.
6. Rajfer J, Rosciszewski A, Mehringer M. Prevalence of corporeal venous leakage in impotent men. J Urol 1988; 140: 69-71.
7. Krall JF, Fittingoff M, Rajfer J. Characterization of cyclic nucleotide and inositol 1,4,5-triphosphate-sensitive calcium-exchange activity of smooth muscle cells cultured from the human corpora cavernosa. Biol Reprod 1988; 39: 913-932.
8. Freedman A, Sikka SC, Rajfer J. Development of rat cavernosal smooth muscle cell culture and its response to papaverine. Surg Forum 1988; 39: 658-659.
9. Katzenstein L. Viagra (sildenafil citrate). The Remarkable Story of the Discovery and the Launch. Medical Information Press: New York, 2001, p 14.
10. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci 1987; 84: 9265-9269.
11. Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, Van Maercke YM, Herman AG. Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 1990; 345: 346-347.
12. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Comm 1990; 170: 843-850.
13. Ignarro LJ, Bush PA, Buga GM, Rajfer J. Neurotransmitter identity doubt. Nature 1990; 347: 131-132.
14. Sjostrand NO, Eldh J, Samuelson UE, Alaranta S, Klinge E. The effects of L-artinine and NG-monomethyl L-arginine on the inhibitory neurotransmission of the human corpus cavernosum penis. Acta Physiol Scand 1990; 140: 297-298.
15. Holmquist F, Stief CG, Jonas U, Andersson KE. Effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol Scand 1991; 143: 299-304.
16. Holmquist F, Hedlund H, Andersson KE. L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum. Acta Physiol Scand 1991; 141: 441-442.
17. Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric-oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest 1991; 88: 112-118.
18. Burnett AL, Lowenstein CJ, Bredt DS, Chang TSK, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science 1992; 257: 401-403.
19. Trigo-Rocha F, Aronson WJ, Hohenfellner M, Ignarro LJ, Rajfer J, Lue TF. Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Am J Physiol 1993; 264: H419-H422.
20. http://news.bbc.co.uk/1/hi/business/1013244.stm, http://www.ims-global. com/insight/news_story/0011/news_story_001113.htm.