Impairment of endothelium- and nerve-mediated relaxation responses in the cavernosal smooth muscle of experimentally diabetic rabbits: Role of weight loss and duration of diabetes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 373, Issue 1, 2006, Pages 71-78

  Bozkurt, Nihan Burul ^a   Pekiner, Can ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Diabetes mellitus; Erectile dysfunction; Rabbit corpus cavernosum; Tissue weight

Indexed keywords

ALLOXAN; CARBACHOL; GLUCOSE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

AGE DISTRIBUTION; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; DISEASE DURATION; ELECTROSTIMULATION; ENDOTHELIUM; EVALUATION; HISTOLOGY; HYPERGLYCEMIA; MALE; NERVE; NONHUMAN; RABBIT; SMOOTH MUSCLE RELAXATION; UREA CYCLE; WEIGHT REDUCTION;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; CARBACHOL; DIABETES MELLITUS, EXPERIMENTAL; ELECTRIC STIMULATION; ENDOTHELIUM, VASCULAR; GLUCOSE; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; NITROPRUSSIDE; PENIS; RABBITS; TIME FACTORS; WEIGHT LOSS;

EID: 33645884141     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0038-5     Document Type: Article

References (41)

1. Andersson KE, Wagner G (1995) Physiology of penile erection. Physiol Rev 75:191-236
2. Azadzoi KM, Saenz de Tejada I (1992) Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 148:1587-1591
3. Azadzoi KM et al (1992) Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J Urol 147:220-225
4. Basu A, Ryder RE (2004) New treatment options for erectile dysfunction in patients with diabetes mellitus. Drugs 64:2667-2688
5. Bivalacqua TJ et al (2000) Pharmacotherapy for erectile dysfunction. Trends Pharmacol Sci 21:484-489
6. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820
7. Brownlee M et al (1984) Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 101:527-537
8. Bush PA et al (1992a) Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol 147:1650-1655
9. Bush PA et al (1992b) Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem Biophys Res Commun 186:308-314
10. Cartledge JJ et al (2001) Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes. BJU Int 87:394-401
11. Cellek S et al (1999) Selective nitrergic neurodegeneration in diabetes mellitus - a nitric oxide-dependent phenomenon. Br J Pharmacol 128:1804-1812
12. Chang S et al (2004) Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits. Am J Physiol Regul Integr Comp Physiol 287:R950-R960
13. Deutsch S, Sherman L (1980) Previously unrecognized diabetes mellitus in sexually impotent men. Jama 244:2430-2432
14. Johnstone MT et al (1993) Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88:2510-2516
15. Keegan A et al (1999) Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia 42:343-350
16. Longhurst PA (1990) The effects of testosterone or insulin treatment on contractile responses of the rat vas deferens following castration or streptozotocin-induced diabetes mellitus. Gen Pharmacol 21:427-434
17. MacLeod KM, McNeill JH (1985) The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels. Can J Physiol Pharmacol 63:52-57
18. Martin-Morales A et al (2001) Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfuncion Erectil Masculina Study. J Urol 166:569-574, discussion 574-565
19. Mayhan WG (1992) Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus. Brain Res 580:297-302
20. McLean WG et al (1992) Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes. Mol Neurobiol 6:225-237
21. Nangle MR et al (2004) Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice. Eur J Pharmacol 502:143-148
22. Otter DJ, Chess-Williams R (1994) The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol 113:576-580
23. Penson DF et al (1996) Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol Reprod 55:567-574
24. Reilly CM et al (1997) Androgenic regulation of NO availability in rat penile erection. J Androl 18:110-115
25. Rendell MS et al (1999) Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA 281:421-426
26. Saenz de Tejada I et al (1989a) Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320:1025-1030
27. Saenz de Tejada I et al (1989b) Regulation of adrenergic activity in penile corpus cavernosum. J Urol 142:1117-1121
28. Saenz de Tejada I et al (1991) Trabecular smooth muscle modulates the capacitor function of the penis. Studies on a rabbit model. Am J Physiol 260:H1590-H1595
29. Sairam K et al (2001) Prevalence of undiagnosed diabetes mellitus in male erectile dysfunction. BJU Int 88:68-71
30. Schirar A et al (1997) Androgens modulate nitric oxide synthase messenger ribonucleic acid expression in neurons of the major pelvic ganglion in the rat. Endocrinology 138:3093-3102
31. Simopoulos DN et al (2001) Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation. J Urol 165:1776-1782
32. Sullivan M et al (1998) Differential alterations of prostacyclin, cyclic AMP and cyclic GMP formation in the corpus cavernosum of the diabetic rabbit. Br J Urol 82:578-584
33. Sullivan ME et al (1996) Autoradiographic localization of nitric oxide synthase binding sites in normal and diabetic rat corpus cavernosum. Eur Urol 30:506-511
34. Tagliabue M et al (2005) Glutathione levels in patients with erectile dysfunction, with or without diabetes mellitus. Int J Androl 28:156-162
35. Tesfamariam B, Cohen RA (1992) Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 263:H321-H326
36. Tesfamariam B (1991) Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 87:1643-1648
37. Uma S et al (1998) Tolerance to isosorbide dinitrate in isolated strips of rabbit corpus cavernosum. Int J Androl 21:364-369
38. Vickers MA, Satyanarayana R (2002) Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res 14:466-471
39. Way KJ, Reid JJ (1999) The effects of diabetes on nitric oxide-mediated responses in rat corpus cavernosum. Eur J Pharmacol 376:73-82
40. Williams SB et al (1998) Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97:1695-1701
41. Wolff SP (1993) Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull 49:642-652