Antisaccades: A probe into the dorsolateral prefrontal cortex in Alzheimer's disease. A critical review

Journal of Alzheimer's Disease

Volumn 19, Issue 3, 2010, Pages 781-793

  Kaufman, Liam D ^a,b   Pratt, Jay ^c   Levine, Brian ^c,d   Black, Sandra E ^a,b,d  

^a Sunnybrook Health Sciences Centre   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d ROTMAN RESEARCH INSTITUTE   (Canada)

Author keywords

Alzheimer's disease; Antisaccades; Dementia; Dorsolateral prefrontal cortex

Indexed keywords

AGING; ALZHEIMER DISEASE; AMNESIA; ANTISACCADE TASK; ATTENTION; BRAIN DEVELOPMENT; DEPTH PERCEPTION; DIAGNOSTIC TEST; DISEASE SEVERITY; EPISODIC MEMORY; HUMAN; MEMORY; NEUROIMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; TASK PERFORMANCE;

EID: 77149122723     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1275     Document Type: Review

References (65)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112-2117.
2. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger- Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746.
3. Fletcher WA, Sharpe JA (1986) Saccadic eye movement dysfunction in Alzheimer's disease. Ann Neurol 20, 464-471.
4. Currie J, Ramsden B, McArthur C, Maruff P (1991) Validation of a clinical antisaccadic eye movement test in the assessment of dementia. Arch Neurol 48, 644-648.
5. Abel LA, Unverzagt F, Yee RD (2002) Effects of stimulus predictability and interstimulus gap on saccades in Alzheimer's disease. Dement Geriatr Cogn Disord 13, 235-243.
6. Shafiq-Antonacci R, Maruff P, Masters C, Currie J (2003) Spectrum of saccade system function in Alzheimer disease. Arch Neurol 60, 1272-1278.
7. Crawford TJ, Higham S, Renvoize T, Patel J, Dale M, Suriya A, Tetley S (2005) Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer's disease. Biol Psychiatry 57, 1052-1060.
8. Mosimann UP, Muri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG (2005) Saccadic eyemovement changes in Parkinson's disease dementia and dementia with Lewy bodies. Brain 128, 1267-1276.
9. Boxer AL, Garbutt S, Rankin KP, Hellmuth J, Neuhaus J, Miller BL, Lisberger SG (2006) Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration. J Neurosci 26, 6354-6363.
10. Garbutt S, Matlin A, Hellmuth J, Schenk AK, Johnson JK, Rosen H, Dean D, Kramer J, Neuhaus J, Miller BL, Lisberger SG, Boxer AL (2008) Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease. Brain 131, 1268-1281.
11. Hallett PE (1978) Primary and secondary saccades to goals defined by instructions. Vision Res 18, 1279-1296.
12. Munoz DP, Everling S (2004). Look away: the anti-saccade task and the voluntary control of eye movement. Nat Rev Neurosci 5, 218-228.
13. Klein C, Foerster F, Hartnegg K, Fischer B (2005) Lifespan development of pro- and anti-saccades: multiple regression models for point estimates. Brain Res Dev Brain Res 160, 113-123.
14. Munoz DP, Broughton JR, Goldring JE, Armstrong IT (1998) Age-related performance of human subjects on saccadic eye movement tasks. Exp Brain Res 121, 391-400.
15. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans AC, Rapoport JL (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2, 861-863.
16. Barnea-Goraly N, Menon V, Eckert M, Tamm L, Bammer R, Karchemskiy A, Dant CC, Reiss AL (2005) White matter development during childhood and adolescence: a crosssectional diffusion tensor imaging study. Cereb Cortex 15, 1848-1854.
17. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14, 21-36.
18. Pfefferbaum A, Sullivan EV(2003) Increased brain white matter diffusivity in normal adult aging: relationship to anisotropy and partial voluming. Magn Reson Med 49, 953-961.
19. Raemaekers M, Vink M, van den Heuvel MP, Kahn RS, Ramsey NF (2006) Effects of aging on BOLD fMRI during prosaccades and antisaccades. J Cogn Neurosci 18, 594-603.
20. Abel LA, Douglas J (2007) Effects of age on latency and error generation in internally mediated saccades. Neurobiol Aging 28, 627-637.
21. Olincy A, Ross RG, Youngd DA, Freedman R (1997) Age diminishes performance on an antisaccade eyemovement task. Neurobiol Aging 18, 483-489.
22. Kimmig H, Greenlee MW, Gondan M, Schira M, Kassubek J, Mergner T (2001) Relationship between saccadic eye movements and cortical activity as measured by fMRI: quantitative and qualitative aspects. Exp Brain Res 141, 184-194.
23. O'Driscoll GA, Alpert NM, Matthysse SW, Levy DL, Rauch SL, Holzman PS (1995) Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proc Natl Acad Sci U S A 92, 925-929.
24. DeSouza JF, Menon RS, Everling S (2003) Preparatory set associated with pro-saccades and anti-saccades in humans investigated with event-related FMRI. J Neurophysiol 89, 1016-1023. (Pubitemid 36206148)
25. McDowell JE, Clementz BA (2001) Behavioral and brain imaging studies of saccadic performance in schizophrenia. Biol Psychol 57, 5-22.
26. Connolly JD, Goodale MA, Desouza JF, Menon RS, Vilis T (2000) A comparison of frontoparietal fMRI activation during anti-saccades and anti-pointing. J Neurophysiol 84, 1645-1655.
27. McDowell JE, Kissler JM, Berg P, Dyckman KA, Gao Y, Rockstroh B, Clementz BA (2005) Electroencephalography/ magnetoencephalography study of cortical activities preceding prosaccades and antisaccades. Neuroreport 16, 663-668.
28. Raemaekers M, Vink M, van den Heuvel MP, Kahn RS, Ramsey NF (2005) Brain activation related to retrosaccades in saccade experiments. Neuroreport 16, 1043-1047.
29. Everling S, Spantekow A, Krappmann P, Flohr H (1998) Event-related potentials associated with correct and incorrect responses in a cued antisaccade task. Exp Brain Res 118, 27-34.
30. Ford KA, Goltz HC, Brown MR, Everling S (2005) Neural processes associated with antisaccade task performance investigated with event-related FMRI. J Neurophysiol 94, 429-440.
31. Stuss DT, Alexander MP (2007) Is there a dysexecutive syndrome? Philos Trans R Soc Lond B Biol Sci 362, 901-915.
32. Guitton D, Buchtel HA, Douglas RM. (1985) Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Exp Brain Res 58, 455-472.
33. Pierrot-Deseilligny C, Rivaud S, Gaymard B, Agid Y (1991) Cortical control of reflexive visually-guided saccades. Brain 114, 1473-1485.
34. Ploner CJ, Gaymard BM, Rivaud-Pechoux S, Pierrot- Deseilligny C (2005) The prefrontal substrate of reflexive saccade inhibition in humans. Biol Psychiatry 57, 1159-1165.
35. Gaymard B, Francois C, Ploner CJ, Condy C, Rivaud-Pechoux S (2003) A direct prefrontotectal tract against distractibility in the human brain. Ann Neurol 53, 542-545.
36. Condy C, Rivaud-Pechoux S, Ostendorf F, Ploner CJ, Gaymard B (2004) Neural substrate of antisaccades: role of subcortical structures. Neurology 63, 1571-1578.
37. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82, 239-259.
38. Pike KE, Savage G, Villemagne VL, Ng S, Moss SA, Maruff P, Mathis CA, Klunk WE, Masters CL, Rowe CC (2007) Betaamyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 130, 2837-2844.
39. Johnson JK, Head E, Kim R, Starr A, Cotman CW (1999) Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol 56, 1233-1239.
40. Josephs KA, Petersen RC, Knopman DS, Boeve BF, Whitwell JL, Duffy JR, Parisi JE, DicksonDW(2006) Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology 66, 41-48.
41. Snowden J, Neary D, Mann D (2007) Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol (Berl) 114, 31-38. (Pubitemid 47029057)
42. Medina D, DeToledo-Morrell L, Urresta F, Gabrieli JD, Moseley M, Fleischman D, Bennett DA, Leurgans S, Turner DA, Stebbins GT (2006) White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study. Neurobiol Aging 27, 663-672.
43. Garrido GE, Furuie SS, Buchpiguel CA, Bottino CM, Almeida OP, Cid CG, Camargo CH, Castro CC, Glabus MF, Busatto GF (2002) Relation between medial temporal atrophy and functional brain activity during memory processing in Alzheimer's disease: a combined MRI and SPECT study. J Neurol Neurosurg Psychiatry 73, 508-516.
44. Grady CL, McIntosh AR, Beig S, Keightley ML, Burian H, Black SE (2003) Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci 23, 986-993.
45. Hutton SB, Ettinger U (2006) The antisaccade task as a research tool in psychopathology: a critical review. Psychophysiology 43, 302-313.
46. Medendorp WP, Goltz HC, Vilis T (2005) Remapping the remembered target location for anti-saccades in human posterior parietal cortex. J Neurophysiol 94, 734-740.
47. Nyffeler T, Rivaud-Pechoux S, Pierrot-Deseilligny C, Diallo R, Gaymard B (2007) Visual vector inversion in the posterior parietal cortex. Neuroreport 18, 917-920.
48. Buck BH, Black SE, Behrmann M, Caldwell C, Bronskill MJ (1997) Spatial- and object-based attentional deficits in Alzheimer's disease. Relationship to HMPAO-SPECT measures of parietal perfusion. Brain 120, 1229-1244
49. Cummings JL, Cole G (2002) Alzheimer disease. JAMA 287, 2335-2338.
50. Tippett WJ, Sergio LE (2006) Visuomotor integration is impaired in early stage Alzheimer's disease. Brain Res 1102, 92-102.
51. Gaymard B, Ploner CJ, Rivaud-Pechoux S, Pierrot-Deseilligny C (1999) The frontal eye field is involved in spatial short-term memory but not in reflexive saccade inhibition. Exp Brain Res 129, 288-301.
52. Machado L, Rafal RD (2004) Control of fixation and saccades during an anti-saccade task: an investigation in humans with chronic lesions of oculomotor cortex. Exp Brain Res 156, 55-63.
53. Perry RJ, Hodges JR (1999) Attention and executive deficits in Alzheimer's disease. A critical review. Brain 122, 383-404.
54. Barton JJ, Goff DC, Manoach DS (2006) The inter-trial effects of stimulus and saccadic direction on prosaccades and antisaccades, in controls and schizophrenia patients. Exp Brain Res 174, 487-1498.
55. Reuter B, Philipp AM, Kathmann N (2006) Effects of switching between leftward and rightward pro- and antisaccades. Biol Psychol 72, 88-95
56. Tatler BW, Hutton SB (2007) Trial by trial effects in the antisaccade task. Exp brain res 179, 387-396
57. Power C, Selnes OA, Grim JA, McArthur JC (1995) HIV Dementia Scale: a rapid screening test. J Acquir Immune Defic Syndr Hum Retrovirol 8, 273-278.
58. van Harten B, Courant MN, Scheltens P,Weinstein HC (2004) Validation of the HIV Dementia Scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus. Dement Geriatr Cogn Disord 18, 109-114.
59. Radant AD, Dobie DJ, Calkins ME, Olincy A, Braff DL, Cadenhead KS, Freedman R, GreenMF, Greenwood TA, Gur RE, Light GA, Meichle SP, Mintz J, Nuechterlein KH, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang MT, Turetsky BI, Tsuang DW (2007) Successful multi-site measurement of antisaccade performance deficits in schizophrenia. Schizophr Res 89, 320-329.
60. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51, 1546-1554.
61. Meyniel C, Rivaud-Pechoux S, Damier P, Gaymard B (2005) Saccade impairments in patients with fronto-temporal dementia. J Neurol Neurosurg Psychiatry 76, 1581-1584.
62. Vidailhet M, Rivaud S, Gouider-Khouja N, Pillon B, Bonnet AM, Gaymard B, Agid Y, Pierrot-Deseilligny C (1994) Eye movements in parkinsonian syndromes. Ann Neurol 35, 420-426.
63. Rivaud-Pechoux S, Vidailhet M, Brandel JP, Gaymard B (2007) Mixing pro- and antisaccades in patients with parkinsonian syndromes. Brain 130, 256-264.
64. Kertesz A, Martinez-Lage P, Davidson W, Munoz DG (2000) The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology 55, 1368-1375.
65. Masellis M, Momeni P, Meschino W, Heffner R Jr, Elder J, Sato C, Liang Y, St George-Hyslop P, Hardy J, Bilbao J, Black S, Rogaeva E (2006) Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome. Brain 129, 3115-3123.