The Pain State Arising From the Laminitic Horse: Insights Into Future Analgesic Therapies

Journal of Equine Veterinary Science

Volumn 30, Issue 2, 2010, Pages 79-82

  Yaksh, Tony L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EQUIDAE;

EID: 76849094694     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2010.01.046     Document Type: Review

References (30)

1. Hood D.M., Wagner I.P., Taylor D.D., Brumbaugh G.W., and Chan M.K. Voluntary limb-load distribution in horses with acute and chronic laminitis. Am J Vet Res 62 (2001) 1393-1398
2. Rietmann T.R., Stauffacher M., Bernasconi P., Auer J.A., and Weishaupt M.A. The association between heart rate, heart rate variability, endocrine and behavioural pain measures in horses suffering from laminitis. J Vet Med A Physiol Pathol Clin Med 51 (2004) 218-225
3. Bowker R.M., Brewer A.M., Vex K.B., Guida L.A., Linder K.E., Sonea I.M., et al. Sensory receptors in the equine foot. Am J Vet Res 54 (1993) 1840-1844
4. Moore R.M., Eades S.C., and Stokes A.M. Laminitis: which pathway is responsible for initiation of this process in horses?. Equine Vet J 36 (2004) 204-209
5. Bailey S.R., Marr C.M., and Elliott J. Current research and theories on the pathogenesis of acute laminitis in the horse. Vet J 167 (2004) 129-142
6. Lunn D.P., and Hurley D.J. The role of leukocyte biology in laminitis. Vet Immunol Immunopathol 129 (2009) 158-160
7. Hucho T., and Levine J.D. Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 55 (2007) 365-376
8. Coutaux A., Adam F., Willer J.C., and Le Bars D. Hyperalgesia and allodynia: peripheral mechanisms. Joint Bone Spine 72 (2005) 359-371
9. Svensson C.I., and Yaksh T.L. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol 42 (2002) 553-583
10. D'Mello R., and Dickenson A.H. Spinal cord mechanisms of pain. Br J Anaesth 101 (2008) 8-16
11. Yaksh T.L. Central pharmacology of nociceptive transmission. In: McMahon S.B., and Koltzenburg M. (Eds). Wall and Melzack's textbook of pain. 5th ed (2006), Elsevier Churchill Livingstone, Philadelphia, PA 371-414
12. Yaksh T.L. Calcium channels as therapeutic targets in neuropathic pain. J Pain 7 1 Suppl. 1 (2006) S13-S30
13. Jones E., Viñuela-Fernandez I., Eager R.A., Delaney A., Anderson H., Patel A., et al. Neuropathic changes in equine laminitis pain. Pain 132 (2007) 321-331
14. Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol 429 (2001) 23-37
15. Lai J., Porreca F., Hunter J.C., and Gold M.S. Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 44 (2004) 371-397
16. Price T.J., Cervero F., and de Koninck Y. Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia. Curr Top Med Chem 5 (2005) 547-555
17. Ramer M.S., Thompson S.W., and McMahon S.B. Causes and consequences of sympathetic basket formation in dorsal root ganglia. Pain Suppl 6 (1999) S111-S120
18. Inoue K., and Tsuda M. Microglia and neuropathic pain. Glia 57 (2009) 1469-1479
19. Milligan E.D., and Watkins L.R. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10 (2009) 23-36
20. Taylor C.P. Mechanisms of analgesia by gabapentin and pregabalin-calcium channel alpha2-delta [Cavalpha2-delta] ligands. Pain 142 (2009) 13-16
21. Mochizucki D. Serotonin and noradrenaline reuptake inhibitors in animal models of pain. Hum Psychopharmacol Suppl 1 (2004) S15-S19
22. Hans G., Schmidt B.L., and Strichartz G. Nociceptive sensitization by endothelin-1. Brain Res Rev 60 (2009) 36-42
23. Bermejo P.E., and Anciones B. Neuromodulators and therapeutic targets in neuropathic pain: from molecules to man. CNS Neurol Disord Drug Targets 8 (2009) 175-183
24. Jarvis M.F., Honore P., Shieh C.C., and Chapman M. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A 104 (2007) 8520-8525
25. Binshtok A.M., Bean B.P., and Woolf C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449 (2007) 607-610
26. Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg 107 (2008) 271-281
27. Wong G.Y., and Gavva N.R. Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. Brain Res Rev 60 (2009) 267-277
28. Brown D.C., Iadarola M.J., Perkowski S.Z., Erin H., Shofer F., Laszlo K.J., et al. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology 103 (2005) 1052-1059
29. Wiley R.G. Substance P receptor-expressing dorsal horn neurons: lessons from the targeted cytotoxin, substance P-saporin. Pain 136 (2008) 7-10
30. Allen J.W., Mantyh P.W., Horais K., Tozier N., Rogers S.D., Ghilardi J.R., et al. Safety evaluation of intrathecal substance P-Saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91 (2006) 286-298