Effect of treadmill exercise on serotonin immunoreactivity in medullary raphe nuclei and spinal cord following sciatic nerve transection in rats

Neurochemical Research

Volumn 35, Issue 3, 2010, Pages 380-389

  Korb, Arthiese ^a   Bonetti, Leandro Viçosa ^a   Da Silva, Sandro Antunes ^a   Marcuzzo, Simone ^a   Ilha, Jocemar ^a   Bertagnolli, Mariane ^a   Partata, Wania Aparecida ^a   Faccioni Heuser, Maria Cristina ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Aerobic exercise; Analgesia; Functional recovery; Pain; Peripheral nervous lesion; Serotonin

Indexed keywords

CITRATE SYNTHASE; SEROTONIN;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CYTOPLASM; DORSAL RAPHE NUCLEUS; ENDURANCE; ENZYME ACTIVITY; MALE; NERVE TRANSECTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SEROTONINERGIC SYSTEM; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; TREADMILL EXERCISE;

AEROBIOSIS; ANIMALS; CITRATE (SI)-SYNTHASE; DENSITOMETRY; HINDLIMB; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SKELETAL; PAIN MEASUREMENT; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; PHYSICAL STIMULATION; RAPHE NUCLEI; RATS; RATS, WISTAR; SCIATIC NERVE; SEROTONIN; SPINAL CORD;

RATTUS;

EID: 76849092538     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-0066-x     Document Type: Article

References (55)

1. GJ Herbison MM Jaweed JF Diturnno 1983 Exercise therapies in peripheral neuropathies Arch Phys Med Rehabil 64 201 205 1:STN:280:DyaL3s3gtlemug%3D%3D 6303270
2. E Linderman P Leffers F Spaans, et al. 1995 Strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: a randomized clinical trial Arch Phys Med Rehabil 76 612 620 10.1016/S0003- 9993(95)80629-6
3. NC Wright DD Kilmer MA McCrory, et al. 1996 Aerobic walking in slowly progressive neuromuscular disease: effect of a 12-week program Arch Phys Med Rehabil 77 64 69 10.1016/S0003-9993(96)90222-1 1:STN:280:DyaK287ktlaksQ%3D%3D 8554477 (Pubitemid 26017494)
4. K Hutchinson F Gómez-Pinilla MJ Crowe, et al. 2004 Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats Brain 127 1403 1414 10.1093/brain/awh160 15069022 (Pubitemid 38745518)
5. PJ O'Conner DB Cook 1999 Exercise and pain: the neurobiology measurement, and laboratory study of pain in relation to exercise in humans Exerc Sport Sci Rev 27 119 166
6. MD Hoffman MA Shepanski SB Ruble, et al. 2004 Intensity and duration threshold for aerobic exercise-induced analgesia to pressure pain Arch Phys Med Rehabil 85 1183 1187 10.1016/j.apmr.2003.09.010 15241771 (Pubitemid 38962381)
7. M Hosseini HA Alaei A Naderi, et al. 2009 Treadmill exercise reduces self-administration of morphine in male rats Pathophysiology 16 3 7 10.1016/j.pathophys.2008.11.001 1:CAS:528:DC%2BD1MXmtVartbY%3D 19131225
8. C Droste MW Greenlee M Schreck H Roskamm 1991 Experimental pain thresholds and plasma beta-endorphin levels during exercise Med Sci Sports Exerc 23 334 342 1:STN:280:DyaK3M3htFGrsQ%3D%3D 2020272
9. KF Koltyn 2002 Exercise-induce hypoalgesia and intensity of exercise Sports Med 32 477 487 10.2165/00007256-200232080-00001 12076175
10. R Meeusen K De Meirleir 1995 Exercise and brain neurotransmission Sports Med 20 160 188 10.2165/00007256-199520030-00004 1:STN:280:DyaK28%2Fptlemug%3D%3D 8571000
11. H Barbeau S Rossignol 1990 The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat Brain Res 514 55 67 10.1016/0006-8993(90)90435-E 1:CAS:528:DyaK3cXktVWjsrc%3D 2357531 (Pubitemid 20147587)
12. E Crown JW Grau 2005 Evidence that descending serotonergic systems protect spinal cord plasticity against the distruptive effect of uncontrollable stimulation Exp Neurol 196 164 176 10.1016/j.expneurol.2005.07.016 1:CAS:528:DC%2BD2MXhtVymsLnE 16139268 (Pubitemid 41416658)
13. LeBars D (1988) Serotonin and pain. In: Osborne NN, Hamon M (eds) Neuronal serotonin. Wiley, New York, pp 171-226
14. BL Jacobs CA Fornal 1995 Activation of 5-HT neuronal activity during motor behavior Neuroscience 7 401 408 1:CAS:528:DyaK28XosVamtA%3D%3D
15. GM Green J Scarth A Dieckenson 2000 An excitatory role for 5-HT in spinal inflamatory nociceptive transmission; state-dependent actions via dorsal horn 5-HT(3) receptors in the anaesthetized rat Pain 89 81 88 10.1016/S0304-3959(00) 00346-8 1:CAS:528:DC%2BD3cXosFCjt74%3D 11113296 (Pubitemid 30953145)
16. R Suzuki LJ Rygh AH Dieckenson 2004 Bad news from the brain: descending 5-HT pathways that control spinal pain processing Trends Pharmacol Sci 25 613 617 10.1016/j.tips.2004.10.002 1:CAS:528:DC%2BD2cXpsVSjtrw%3D 15530638 (Pubitemid 39458166)
17. W Rahman R Suzuki M Webber, et al. 2006 Depletion of endogenous spinal 5HT attenuates the behavioral hypersensitivity to mechanical cooling stimuli induced by spinal nerve ligation Pain 123 264 274 10.1016/j.pain.2006.02.033 1:CAS:528:DC%2BD28XmslGrurY%3D 16644129
18. Fields HL, Basbaum AI (1994) Central nervous system mechanisms of pain modulation. In: Wall PD, Melzack R (eds) Textbook of pain, 3rd edn. Churchill Livingstone, Edinburgh, pp 243-257
19. BL Jacobs FJ Martin-Cora CA Fornal 2002 Activity of medullary serotonergic neurons in freely moving animals Brain Res Rev 40 45 52 10.1016/S0165-0173(02)00187-X 1:CAS:528:DC%2BD3sXhslWjug%3D%3D 12589905 (Pubitemid 36183157)
20. G Holstege HGJM Kuypers 1987 Brainstem projections to spinal motoneurons: an update Neuroscience 23 809 821 10.1016/0306-4522(87)90160-6 1:STN:280:DyaL1c7ktlCisQ%3D%3D 2893995 (Pubitemid 18014398)
21. E Jankowska I Hammar B Chojnicka, et al. 2000 Effect of monoamines on interneurons in four spinal reflex pathways from group I and/or group II muscle afferents Eur J Neurosci 12 701 714 10.1046/j.1460-9568.2000.00955.x 1:STN:280:DC%2BD3c7nslKntA%3D%3D 10712650 (Pubitemid 30142772)
22. G Guilbaud M Peschanski M Gautron, et al. 1980 Response of neurons of the nucleus raphe magnus to noxious stimuli Neurosci Lett 17 149 154 10.1016/0304-3940(80)90076-2 1:STN:280:DyaL3s7ptlWmtg%3D%3D 7052457
23. S Auerbach C Fornal B Jacobs 1985 Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxiousstimuli, and periaqueductal gray stimulation in freely moving cats Exp Neurol 88 609 628 10.1016/0014-4886(85)90075-5 1:CAS:528:DyaL2MXkt1SmsrY%3D 3996512 (Pubitemid 15027228)
24. BC Hains AW Everhart SD Fullwood, et al. 2002 Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity involvement in chronic central pain after spinal hemisection in the rat Exp Neurol 175 347 362 10.1006/exnr.2002.7892 1:CAS:528:DC%2BD38XksVequro%3D 12061865 (Pubitemid 34634289)
25. H Horiuchi T Ogata T Morino, et al. 2002 Serotonergic signaling inhibits hiperalgesia induced by spinal cord damage Brain Res 963 312 320 10.1016/S0006-8993(02)04055-6
26. SC Veasey CA Fornal CW Metzler, et al. 1997 Single-unit changes in responses of serotonergic dorsal raphe neurons to specific motor challenges in freely moving cats Neuroscience 79 161 169 10.1016/S0306-4522(96)00673-2 1:CAS:528:DyaK2sXjvVahsL0%3D 9178872 (Pubitemid 27245007)
27. BJ Schmidt LM Jordan 2000 The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord Brain Res Bul 5 689 710 10.1016/S0361-9230(00)00402-0 (Pubitemid 32114321)
28. C Gerin JR Teilhac K Smith A Privat 2008 Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord Neurosci Lett 436 91 95 10.1016/j.neulet.2008.01.081 1:CAS:528:DC%2BD1cXkvVyitbg%3D 18400395
29. MH Bement KA Sluka 2005 Low- intensity exercise reverses chronic muscle pain in the rat in naloxone-dependent manner Arch Phys Med Rehabil 86 1736 1740 10.1016/j.apmr.2005.03.029 16181935 (Pubitemid 41354183)
30. SB Ruble MD Hoffman MA Shepanski, et al. 2005 Thermal pain perception after aerobic exercise Arch Phys Med Rehabil 86 1019 1023 10.1016/j.apmr.2004. 09.024 15895351 (Pubitemid 40692372)
31. P Alp E Newsholme V Zammit 1976 Activities of citrate synthase and NAD+ -linked and NADP+ -linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates Biochem J 154 689 700 1:CAS:528:DyaE28XktFGrtrs%3D 8036
32. J Ilha RT Araújo T Malysz, et al. 2008 Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats Neurorehabil Neural Repair 22 355 366 18326889
33. W Partata AMR Krepsky LL Xavier, et al. 1999 Distribution of glycogen phosphorylase and cytochrome oxidase in the central nervous system of the turtle Trachemys dorbigni Comp Biochem Physiol A Mol Integr Physiol 124 113 122 10.1016/S1095-6433(99)00100-2 1:STN:280:DC%2BD3c%2FpsFCitA%3D%3D 10629952 (Pubitemid 29509770)
34. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates, 4th edn. Academic Press Inc., San Diego
35. S Dey RH Singh PK Dey 1992 Exercise training: significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise Physiol Behav 52 1095 1099 10.1016/0031-9384(92)90465-E 1:CAS:528:DyaK3sXpsVyjuw%3D%3D 1283013
36. ZY Liu DB Zhuang T Lunderberg, et al. 2002 Involvement of 5-Hydroxytryptamines1A receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal in intact rats, rats with nerve injury and rats with inflammation Neuroscience 112 399 407 10.1016/S0306-4522(02) 00038-6 1:CAS:528:DC%2BD38XktVaru74%3D 12044457 (Pubitemid 34607023)
37. V Smith C Beyer M Brandt 2005 Neurochemical changes in RMV associated with peripheral inflammatory pain stimuli Brain Res 1095 65 67 10.1016/j.brainres.2006.04.018
38. BS Brow T Payne C Kim G Moore, et al. 1979 Chronic response of rat brain norepinefrine and serotonin levels to endurance training J Appl Physiol 46 19 23
39. C Gerin D Becquet A Privat 1995 Direct evidence for the link in-between monoaminergic descending pathways and motor activity. I. A study with microdialysis probes implanted in the ventral funiculus of the spinal cord Brain Res 704 191 201 10.1016/0006-8993(95)01111-0 1:CAS:528:DyaK2MXhtVSgsLvI 8788914 (Pubitemid 26009940)
40. JM Millan 1999 The induction of pain: an integrative Rev Prog Neurobiol 57 1 164 10.1016/S0301-0082(98)00048-3 1:CAS:528:DyaK1MXitVOjsA%3D%3D (Pubitemid 28551764)
41. MM Heinricher I Tavares JL Leith, et al. 2008 Descending control of nociception: specifity recruitment and plasticity Brain Res Rev 60 214 225 10.1016/j.brainresrev.2008.12.009 19146877
42. R Suzuki W Rahman SP Hunt, et al. 2004 Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury Brain Res 1019 68 76 10.1016/j.brainres.2004. 05.108 1:CAS:528:DC%2BD2cXmslems7k%3D 15306240 (Pubitemid 39078612)
43. WJ Huang BR Wang LB Yao, et al. 2000 Activity of p44/42 MAP kinase in the caudal subnucleos of trigeminal spinal nucleos is increased following perioral noxious stimulation in the mouse Brain Res 861 181 185 10.1016/S0006-8993(00) 02015-1 1:CAS:528:DC%2BD3cXit1Whtr4%3D 10751581 (Pubitemid 30177299)
44. RR Ji H Babu GJ Brenner, et al. 2002 ERK MAP kinase activation in superficial spinal cord neurons contributes to pain hypersensitivity J Neurosci 22 478 485 1:CAS:528:DC%2BD38XmsVOgsw%3D%3D 11784793
45. H Imbe K Okamoto T Okamura S Kumabe M Nakatsuka F Aikawa Y Iwaii-Liao E Senba 2005 Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla Brain Res 1063 151 158 10.1016/j.brainres.2005.09. 057 1:CAS:528:DC%2BD2MXht12rsrzE 16288729 (Pubitemid 41741026)
46. JP Rivot D Pointis JM Besson 1988 Morphine increase 5-HT metabolism in the nucleus raphe magnus: an in vivo study in freely moving rats using 5-hydroxyindole electrochemical detection Brain Res 446 333 342 10.1016/0006-8993(88)90892-X 1:CAS:528:DyaL1cXhvFygt7o%3D 3370493 (Pubitemid 18101117)
47. R Tao SB Auerbach 1995 Involvement of dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain Neuroscience 68 553 561 10.1016/0306-4522(95)00154-B 1:CAS:528: DyaK2MXntF2jtr0%3D 7477965
48. BL Jacobs EC Azmitia 1992 Structure and function of the serotonin system Physiol Rev 72 165 229 1:CAS:528:DyaK38XhsVCjs7Y%3D 1731370
49. CA Fornal FJ Martin-Cora BL Jacobs 2006 "Fatigue" of medullary but not mesencephalic raphe serotonergic neurons during locomotion in cats Brain Res 1072 55 61 10.1016/j.brainres.2005.12.007 1:CAS:528:DC%2BD28XhvVWmtLo%3D 16412992 (Pubitemid 43255451)
50. W Xie JA Strong JTA Meij, et al. 2004 Neuropatic pain: early afferent activity is the trigger Pain 116 234 256
51. +2 signal in axotomized sensory neurons of rats Anesthesiology 107 106 116 10.1097/01.anes.0000267538.72900.68 1:CAS:528:DC%2BD2sXmslygur4%3D 17585222 (Pubitemid 46987826)
52. GM Tyce TL Yaksh 1981 Monoamina release from cat spinal cord by somatic stimuli: an intrinsic modulatory system J Physiol 314 513 529 1:CAS:528:DyaL3MXktVCjtbc%3D 7310700
53. E Gutmann B Jakoubek 1963 Effect of increased motor activity on regeneration of the peripheral nerve in young rats Physiol Bohemoslov 12 463 468 1:STN:280:DyaF2c%2FlsFGnsw%3D%3D 14097862
54. AA Eisen S Carpenter G Karpati, et al. 1973 The effect of muscle hyper- and hypoactivity upon fibre diameters of intact and regenerating nerves J Neurol Sci 20 457 469 10.1016/0022-510X(73)90176-7 1:STN:280:DyaE2c%2FotFCksg%3D%3D 4772398
55. R Molteni J-Q Zheng Z Ying F Gómez-Pinilla JL Twiss 2004 Voluntary exercise increases axonal regeneration from sensory neurons Proc Natl Acad Sci USA 101 8473 8478 10.1073/pnas.0401443101 1:CAS:528:DC%2BD2cXkvFOmtrk%3D 15159540 (Pubitemid 38736599)