Motor activity induces release of serotonin in the dorsal horn of the rat lumbar spinal cord

Neuroscience Letters

Volumn 436, Issue 2, 2008, Pages 91-95

  Gerin, Christine ^a,b   Teilhac, Jean Rene ^a   Smith, Kristin ^c   Privat, Alain ^a  

^a Montpellier University Medical Center   (France)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c CSU   (United States)

Author keywords

5 HT; Exercise; Microdialysis; Motor function; Spinal cord

Indexed keywords

NEUROTRANSMITTER; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUMBAR SPINAL CORD; MALE; MICRODIALYSIS; MOTOR ACTIVITY; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SPINAL CORD DORSAL HORN; TREADMILL EXERCISE;

ANIMALS; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXYINDOLEACETIC ACID; LUMBOSACRAL REGION; MALE; MICRODIALYSIS; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPINAL CORD; TIME FACTORS;

EID: 41949105482     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.01.081     Document Type: Article

References (16)

1. Basbaum A.I., Clanton C.H., and Fields H.L. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J. Comp. Neurol. 178 (1978) 209-224
2. Diaz-Rios M.E., Dombeck D.A., Webb W.W., and Harris-Warrick R.M. Serotonin modulates dendritic calcium influx in commissural interneurons in the mouse spinal locomotor network. J. Neurophysiol. 98 (2007) 2157-2167
3. Doly S., Fischer J., Brisorgueil M.J., Verge D., and Conrath M. 5-HT5A receptor localization in the rat spinal cord suggests a role in nociception and control of pelvic floor musculature. J. Comp. Neurol. 476 (1994) 316-329
4. Gerin C., Becquet D., and Privat A. Direct evidence for the link in-between monoaminergic descending pathways and motor activity. I. A study with microdialysis probes implanted in the ventral funiculus of the spinal cord. Brain Res. 704 (1995) 191-201
5. Gerin C., Legrand A., and Privat A. Study of 5-HT release with a chronically implanted microdialysis probe in the ventral horn of the spinal cord of unrestrained rats during exercise on a treadmill. J. Neurosci. Methods 52 (1994) 129-141
6. Gerin C., and Privat A. Evaluation of the function of microdialysis probes permanently implanted in the rat CNS and coupled to an on-line HPLC system of analysis. J. Neurosci. Methods 66 (1996) 81-92
7. Gerin C., and Privat A. Direct evidence for the link in-between monoaminergic descending pathways and motor activity. II. A study with microdialysis probes implanted in the ventral horn of the spinal cord. Brain Res. 794 (1998) 169-173
8. Jankowska E., Hammar I., Chojnicka B., and Heden C.H. Effect of monoamines on interneurons in four spinal reflex pathways from group I and/or group II muscle afferents. Eur. J. Neurosci 12 (2000) 701-714
9. Jankowska E., Hammar I., Djouhri L., Heden C., Szabo Lackberg Z., and Yin X.K. Modulations of responses of four types of feline ascending tract neurons by serotonin and noradrenaline. Eur. J. Neurosci. 9 (1997) 1375-1387
10. Liu F.Y., Xing G.G., Qu X.X., Xu I.S., Han J.S., and Wan Y. Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. J. Pharmacol. Exp. Ther. 321 3 (2007) 1046-1053
11. Molander C., Xu Q., and Grant G. The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J. Comp. Neurol. 230 (1984) 133-141
12. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1982), Academic Press, Sydney
13. Schmidt B.J., and Jordan L.M. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull. 53 (2000) 689-710
14. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6 (1981) 557-618
15. Westerink B.H., and Tuinte M.H. Chronic use of intracerebral dialysis for the in vivo measurement of 3,4-dihydroxyphenylethylamine and its metabolite 3,4-dihydroxyphenylacetic acid. J. Neurochem. 46 (1986) 181-185
16. Zimmer M.B., and Goshgarian H.G. Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. J. Spinal Cord Med. 29 (2006) 147-155