The adenovirus-mediated linamarase/linamarin suicide system: A potential strategy for the treatment of hepatocellular carcinoma

Cancer Letters

Volumn 289, Issue 2, 2010, Pages 217-227

  Li, Jun ^a   Li, Haimin ^a   Zhu, Liang ^b   Song, Wenjie ^a   Li, Ren ^a   Wang, Desheng ^a   Dou, Kefeng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bystander effect; Hepatocellular carcinoma; Linamarase; Linamarin; Suicide gene therapy

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; LINAMARASE; LINAMARIN; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; ENERGY METABOLISM; GENE CONSTRUCT; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; NONHUMAN; PRIORITY JOURNAL; REPEATED DRUG DOSE; SUICIDE GENE THERAPY; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; BETA-GLUCOSIDASE; BLOTTING, WESTERN; BYSTANDER EFFECT; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, TRANSGENIC, SUICIDE; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NECROSIS; NITRILES; ONCOLYTIC VIROTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ADENOVIRIDAE; ANIMALIA; MANIHOT ESCULENTA; MUS MUSCULUS;

EID: 76849086911     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.016     Document Type: Article

References (44)

1. Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma. Lancet 362 (2003) 1907-1917
2. Mazzaferro V., Chun Y.S., Poon R.T., Schwartz M.E., Yao F.Y., Marsh J.W., Bhoori S., and Lee S.G. Liver transplantation for hepatocellular carcinoma. Ann. Surg. Oncol. 15 (2008) 1001-1007
3. Cross D., and Burmester J.K. Gene therapy for cancer treatment: past, present and future. Clin. Med. Res. 4 (2006) 218-227
4. Seth P. Vector-mediated cancer gene therapy: an overview. Cancer Biol. Ther. 4 (2005) 512-517
5. Portsmouth D., Hlavaty J., and Renner M. Suicide genes for cancer therapy. Mol. Aspects Med. 28 (2007) 4-41
6. Kwon H.C., Kim J.H., Kim K.C., Lee K.H., Lee J.H., Lee B.H., Lee K.H., Jang J.J., Lee C.T., Lee H., and Kim C.M. In vivo antitumor effect of herpes simplex virus thymidine kinase gene therapy in rat hepatocellular carcinoma: feasibility of adenovirus-mediated intra-arterial gene delivery. Mol. Cells 11 (2001) 170-178
7. Faneca H., Faustino A., and Pedroso D.L.M. Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes. J. Control Release 126 (2008) 175-184
8. Park S.Y., Lee W., Lee J., and Kim I.S. Combination gene therapy using multidrug resistance (MDR1) gene shRNA and herpes simplex virus-thymidine kinase. Cancer Lett. 261 (2008) 205-214
9. Fillat C., Carrio M., Cascante A., and Sangro B. Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application. Curr. Gene Ther. 3 (2003) 13-26
10. Santana M.A., Vasquez V., Matehus J., and Aldao R.R. Linamarase expression in cassava cultivars with roots of low- and high-cyanide content. Plant Physiol. 129 (2002) 1686-1694
11. Selmar D., Carvalho F.J., and Conn E.E. A colorimetric assay for alpha-hydroxynitrile lyase. Anal. Biochem. 166 (1987) 208-211
12. Jensen P., Wilson M.T., Aasa R., and Malmstrom B.G. Cyanide inhibition of cytochrome c oxidase, a rapid-freeze e.p.r. investigation. Biochem. J. 224 (1984) 829-837
13. Cortes M.L., Garcia-Escudero V., Hughes M., and Izquierdo M. Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system. J. Gene Med. 4 (2002) 407-414
14. Lambert J., Ramasamy J., and Paukstelis J. Stable reagents for the colorimetric determination of cyanide by modified Koenig reactions. Anal. Chem. 47 (1975) 916-918
15. Tzukert K., Gorodestky R., Avrahami I., Krasny L., Shimony N., Elkin G., Nettelbeck D.M., and Haviv Y.S. A novel dynamic matrix detachment model reveals a shift from apoptosis to necrosis in melanoma cells. Cancer Lett. 272 (2008) 345-354
16. Menze M.A., Clavenna M.J., and Hand S.C. Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio. Am. J. Physiol. Regul. Integr.Comp. Physiol. 288 (2005) 501-510
17. Cortes M.L., de Felipe P., Martin V., Hughes M.A., and Izquierdo M. Successful use of a plant gene in the treatment of cancer in vivo. Gene Ther. 5 (1998) 1499-1507
18. Voiculescu M., Winkler R.E., Moscovici M., and Neuman M.G. Chemotherapies and targeted therapies in advanced hepatocellular carcinoma: from laboratory to clinic. J. Gastrointestin Liver Dis. 17 (2008) 315-322
19. Gottesman M.M. How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 53 (1993) 747-754
20. Park J.G., Lee S.K., Hong I.G., Kim H.S., Lim K.H., Choe K.J., Kim W.H., Kim Y.I., Tsuruo T., and Gottesman M.M. MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J. Natl. Cancer Inst. 86 (1994) 700-705
21. Ozturk M. P53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet 338 (1991) 1356-1359
22. Swinnen J.V., Beckers A., Brusselmans K., Organe S., Segers J., Timmermans L., Vanderhoydonc F., Deboel L., Derua R., Waelkens E., DeSchrijver E., VandeSande T., Noel A., Foufelle F., and Verhoeven G. Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res. 65 (2005) 2441-2448
23. Garber K. Energy deregulation: licensing tumors to grow. Science 312 (2006) 1158-1159
24. Xu R.H., Pelicano H., Zhou Y., Carew J.S., Feng L., Bhalla K.N., Keating M.J., and Huang P. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res. 65 (2005) 613-621
25. Xu G., and McLeod H.L. Strategies for enzyme/prodrug cancer therapy. Clin. Cancer Res. 7 (2001) 3314-3324
26. Schuster M.J., and Wu G.Y. Gene therapy for hepatocellular carcinoma: progress but many stones yet unturned!. Gastroenterology 112 (1997) 656-659
27. Mulligan R.C. The basic science of gene therapy. Science 260 (1993) 926-932
28. Link N., Aubel C., Kelm J.M., Marty R.R., Greber D., Djonov V., Bourhis J., Weber W., and Fussenegger M. Therapeutic protein transduction of mammalian cells, mice by nucleic acid-free lentiviral nanoparticles. Nucleic Acids Res. 34 (2006) e16
29. Mkpong O.E., Yan H., Chism G., and Sayre R.T. Purification, Characterization, and Localization of Linamarase in Cassava. Plant Physiol. 93 (1990) 176-181
30. Akintonwa A., and Tunwashe O.L. Fatal cyanide poisoning from cassava-based meal. Hum. Exp. Toxicol. 11 (1992) 47-49
31. Hernandez T., Lundquist P., Oliveira L., Perez C.R., Rodriguez E., and Rosling H. Fate in humans of dietary intake of cyanogenic glycosides from roots of sweet cassava consumed in Cuba. Nat. Toxins 3 (1995) 114-117
32. Frakes R.A., Sharma R.P., and Willhite C.C. Comparative metabolism of linamarin and amygdalin in hamsters. Food Chem. Toxicol. 24 (1986) 417-420
33. Mesnil M., and Yamasaki H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 60 (2000) 3989-3999
34. Shirakawa T., Gardner T.A., Ko S.C., Bander N., Woo S., Gotoh A., Kamidono S., Chung L.W., and Kao C. Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model. J. Urol. 162 (1999) 949-954
35. Borowitz J.L., Rathinavelu A., Kanthasamy A., Wilsbacher J., and Isom G.E. Accumulation of labeled cyanide in neuronal tissue. Toxicol. Appl. Pharmacol. 129 (1994) 80-85
36. Krohne T.U., Shankara S., Geissler M., Roberts B.L., Wands J.R., Blum H.E., and Mohr L. Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro. Hepatology 34 (2001) 511-518
37. Kousparou C.A., Epenetos A.A., and Deonarain M.P. Antibody-guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells. Int. J. Cancer 99 (2002) 138-148
38. Fabregat I., Roncero C., and Fernandez M. Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int. 27 (2007) 155-162
39. Yang W.S., Park S.O., Yoon A.R., Yoo J.Y., Kim M.K., Yun C.O., and Kim C.W. Suicide cancer gene therapy using pore-forming toxin, streptolysin O. Mol. Cancer Ther. 5 (2006) 1610-1619
40. Leavesley H.B., Li L., Prabhakaran K., Borowitz J.L., and Isom G.E. Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol. Sci. 101 (2008) 101-111
41. Tatsumi T., Shiraishi J., Keira N., Akashi K., Mano A., Yamanaka S., Matoba S., Fushiki S., Fliss H., and Nakagawa M. Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes. Cardiovasc. Res. 59 (2003) 428-440
42. Garcia-Escudero V., Gargini R., and Izquierdo M. Glioma regression in vitro and in vivo by a suicide combined treatment. Mol. Cancer Res. 6 (2008) 407-417
43. Hardie D.G. The AMP-activated protein kinase pathway - new players upstream and downstream. J. Cell Sci. 117 (2004) 5479-5487
44. Motoshima H., Goldstein B.J., Igata M., and Araki E. AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol. 574 (2006) 63-71