Activation of α6-containing GABAA receptors by pentobarbital occurs through a different mechanism than activation by GABA

Neuroscience Letters

Volumn 471, Issue 3, 2010, Pages 195-199

  Fisher, Matthew T ^a   Fisher, Janet L ^b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Barbiturates; GABA; Mutation; Patch clamp

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA 1 SUBUNIT; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA 6 SUBUNIT; 4 AMINOBUTYRIC ACID RECEPTOR; LYSINE; METHIONINE; PENTOBARBITAL; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALPHA1 SUBUNIT, GABA A RECEPTOR; ALPHA1 SUBUNIT, GABA-A RECEPTOR; ALPHA6 SUBUNIT, GABA A RECEPTOR; ALPHA6 SUBUNIT, GABA-A RECEPTOR;

ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; WHOLE CELL; ANIMAL; BINDING SITE; CELL LINE; DRUG POTENTIATION; GENETICS; MUTATION; PHYSIOLOGY;

ANIMALS; BINDING SITES; CELL LINE; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MUTATION; PATCH-CLAMP TECHNIQUES; PENTOBARBITAL; RATS; RECEPTORS, GABA-A;

EID: 76749158292     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.01.041     Document Type: Article

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