SCOPUS 정보 검색 플랫폼

Volumn 396, Issue 3, 2010, Pages 1291-1300

Analysis of potential genotoxic impurities in pharmaceuticals by two-dimensional gas chromatography with Deans switching and independent column temperature control using a low-thermal-mass oven module

(5) David, Frank a Jacq, Karine a Sandra, Pat a Baker, Andrew b Klee, Matthew S c

a Research Institute for Chromatography (Belgium)

b ASTRAZENECA (United Kingdom)

c AGILENT TECHNOLOGIES (United States)

Author keywords

Capillary flow technology; Low thermal mass oven; Pharmaceuticals; Potential genotoxic impurities; Two dimensional capillary GC

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; ANALYTES; ANALYTICAL METHOD; CAPILLARY COLUMNS; CAPILLARY-FLOW TECHNOLOGY; CARBAMAZEPINE; COLUMN TEMPERATURE; CONCENTRATED SOLUTION; DERIVATIZATIONS; FLOW TECHNOLOGY; GENOTOXIC IMPURITIES; LIMIT OF DETECTION; LOW DETECTION LIMIT; MS DETECTION; PARTS PER MILLIONS; QUANTITATIVE DETERMINATIONS; REPRODUCIBILITIES; SECOND-DIMENSION COLUMN; TEST MATRIX; TWO DIMENSIONAL GAS CHROMATOGRAPHY;

AMIDES; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DETECTORS; DRUG PRODUCTS; GAS CHROMATOGRAPHY; IMPURITIES; OVENS; STOVES; TARGETS; TWO DIMENSIONAL;

TRACE ANALYSIS;

ALCOHOL DERIVATIVE; ANALGESIC AGENT; CARBAMAZEPINE; DRUG; MUTAGENIC AGENT;

ARTICLE; EQUIPMENT DESIGN; EVALUATION; INSTRUMENTATION; MASS FRAGMENTOGRAPHY; METHODOLOGY; STATISTICAL PARAMETERS;

ALCOHOLS; ANALGESICS, NON-NARCOTIC; CARBAMAZEPINE; EQUIPMENT DESIGN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIMIT OF DETECTION; MUTAGENS; PHARMACEUTICAL PREPARATIONS;

APIS;

EID: 76749154491 PISSN: 16182642 EISSN: 16182650 Source Type: Journal
DOI: 10.1007/s00216-009-3304-9 Document Type: Article

Times cited : (34)

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