Determination of low ppm levels of dimethyl sulfate in an aqueous soluble API intermediate using liquid-liquid extraction and GC-MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 1054-1059

  Zheng, Jie ^a   Pritts, Wayne A ^a   Zhang, Shuhong ^a   Wittenberger, Steve ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

API intermediate; Dimethyl sulfate; GC MS; Genotoxic impurity; Trace analysis

Indexed keywords

DIMETHYL SULFATE; TERT BUTYL METHYL ETHER;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG IMPURITY; GENOTOXICITY; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CHEMISTRY; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROLYSIS; IONS; MODELS, CHEMICAL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFURIC ACID ESTERS; WATER;

EID: 70349163688     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.06.022     Document Type: Article

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