Development and validation of a sensitive GC-MS method for the determination of trace levels of an alkylating reagent in a β-lactam active pharmaceutical ingredient

Journal of Pharmaceutical and Biomedical Analysis

Volumn 39, Issue 3-4, 2005, Pages 486-494

  Li, Hanlin ^a   Sluggett, Gregory W ^a  

^a PFIZER INC   (United States)

Author keywords

Active pharmaceutical ingredient; Alkylating agent; GC MS; Selected ion monitoring; Trace assays

Indexed keywords

ALKYLATING AGENT; BETA LACTAM ANTIBIOTIC;

ACCURACY; ARTICLE; ELECTRON CAPTURE DETECTION; GAS CHROMATOGRAPHY; INJECTION; INTERMETHOD COMPARISON; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; STANDARDIZATION; TEMPERATURE; VALIDATION PROCESS;

ALKYLATING AGENTS; BETA-LACTAMS; CARBONIC ACID; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, LIQUID; DRUG INDUSTRY; ELECTRONS; ESTERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; IONS; MODELS, CHEMICAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TEMPERATURE; TIME FACTORS;

EID: 23944435696     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.04.042     Document Type: Article

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