Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: A meta-analysis of published studies

British Journal of Anaesthesia

Volumn 104, Issue 2, 2010, Pages 216-223

  Dahmani, S ^a   Stany, I ^a   Brasher, C ^a   Lejeune, C ^a   Bruneau, B ^a   Wood, C ^a   Nivoche, Y ^a   Constant, I ^b   Murat, I ^b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b ARMAND TROUSSEAU HOSPITAL   (France)

Author keywords

Anaesthetic techniques, regional, caudal; Anaesthetics i.v., clonidine; Anaesthetics i.v., fentanyl; Anaesthetics i.v., propofol; Emergence agitation

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; DESFLURANE; DEXMEDETOMIDINE; FENTANYL; KETAMINE; LOCAL ANESTHETIC AGENT; MIDAZOLAM; ONDANSETRON; PROPOFOL; SEROTONIN ANTAGONIST; SEVOFLURANE; TROPISOTRON; UNCLASSIFIED DRUG;

AGITATION; ANALGESIA; ANESTHESIA; ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; EMERGENCE AGITATION; HUMAN; INCIDENCE; INTRAOPERATIVE PERIOD; MENTAL DISEASE; META ANALYSIS; PRIORITY JOURNAL; PUBLICATION; SYSTEMATIC REVIEW;

EID: 76749154434     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep376     Document Type: Article

References (62)

1. Aouad MT, Kanazi GE, Siddik-Sayyid SM, Gerges FJ, Rizk LB, Baraka AS. Preoperative caudal block prevents emergence agitation in children following sevoflurane anesthesia. Acta Anaesthesiol Scand 2005; 49: 300-304
2. Yamashita M. Postanaesthetic excitation and agitation. Paediatr Anaesth 2003; 13: 641
3. Johr M. Postanaesthesia excitation. Paediatr Anaesth 2002; 12: 293-295
4. Johr M, Berger TM. Paediatric anaesthesia and inhalation agents. Best Pract Res Clin Anaesthesiol 2005; 19: 501-522
5. Voepel-Lewis T, Malviya S, Tait AR. A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesth Analg 2003; 96: 1625-1630
6. Silva LM, Braz LG, Modolo NS. Emergence agitation in pediatric anesthesia: current features. J Pediatr (Rio J) 2008; 84: 107-113
7. Goa KL, Noble S, Spencer CM. Sevoflurane in paediatric anaesthesia: a review. Paediatr Drugs 1999; 1: 127-153
8. Veyckemans F. Excitation and delirium during sevoflurane anesthesia in pediatric patients. Minerva Anestesiol 2002; 68: 402-405
9. Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999; 354: 1896-1900
10. Chinn S. A simple method for converting an odds ratio to effect size for use in meta-analysis. Stat Med 2000; 19: 3127-3131
11. Funk W, Hollnberger H, Geroldinger J. Physostigmine and anaesthesia emergence delirium in preschool children: a randomized blinded trial. Eur J Anaesthesiol 2008; 25: 37-42
12. Gouda N. The effects of single bolus dose of remifentanil on the emergence characteristics of paediatric patients undergoing myringotomy after sevoflurane anaesthesia. Egypt J Anaesth 2004; 20: 63-66
13. Mayer J, Boldt J, Rohm KD, Scheuermann K, Suttner SW. Desflurane anesthesia after sevoflurane inhaled induction reduces severity of emergence agitation in children undergoing minor ear-nose-throat surgery compared with sevoflurane induction and maintenance. Anesth Analg 2006; 102: 400-404
14. Oh AY, Seo KS, Kim SD, Kim CS, Kim HS. Delayed emergence process does not result in a lower incidence of emergence agitation after sevoflurane anesthesia in children. Acta Anaesthesiol Scand 2005; 49: 297-299
15. Shibata S, Shigeomi S, Sato W, Enzan K. Nitrous oxide administration during washout of sevoflurane improves postanesthetic agitation in children. J Anesth 2005; 19: 160-163
16. Cohen IT, Drewsen S, Hannallah RS. Propofol or midazolam do not reduce the incidence of emergence agitation associated with desflurane anaesthesia in children undergoing adenotonsillectomy. Paediatr Anaesth 2002; 12: 604-609
17. Kain ZN, Caldwell-Andrews AA, Mayes LC, et al. Family-centered preparation for surgery improves perioperative outcomes in children: a randomized controlled trial. Anesthesiology 2007; 106: 65-74
18. Viitanen H, Annila P, Viitanen M, Tarkkila P. Premedication with midazolam delays recovery after ambulatory sevoflurane anesthesia in children. Anesth Analg 1999; 89: 75-79 (Pubitemid 29293312)
19. Viitanen H, Annila P, Viitanen M, Yli-Hankala A. Midazolam premedication delays recovery from propofol-induced sevoflurane anesthesia in children 1-3 yr. Can J Anaesth 1999; 46: 766-771 (Pubitemid 29426468)
20. Lapin SL, Auden SM, Goldsmith LJ, Reynolds AM. Effects of sevoflurane anaesthesia on recovery in children: a comparison with halothane. Paediatr Anaesth 1999; 9: 299-304
21. Grundmann U, Uth M, Eichner A, Wilhelm W, Larsen R. Total intravenous anaesthesia with propofol and remifentanil in paediatric patients: a comparison with a desflurane-nitrous oxide inhalation anaesthesia. Acta Anaesthesiol Scand 1998; 42: 845-850 (Pubitemid 28332031)
22. Steinmetz J, Holm-Knudsen R, Sorensen MK, Eriksen K, Rasmussen LS. Hemodynamic differences between propofol- remifentanil and sevoflurane anesthesia for repair of cleft lip and palate in infants. Paediatr Anaesth 2007; 17: 32-37
23. Lopez Gil ML, Brimacombe J, Clar B. Sevoflurane versus propofol for induction and maintenance of anaesthesia with the laryngeal mask airway in children. Paediatr Anaesth 1999; 9: 485-490
24. Picard V, Dumont L, Pellegrini M. Quality of recovery in children: sevoflurane versus propofol. Acta Anaesthesiol Scand 2000; 44: 307-310
25. Uezono S, Goto T, Terui K, et al. Emergence agitation after sevoflurane versus propofol in pediatric patients. Anesth Analg 2000; 91: 563-566
26. Nakayama S, Furukawa H, Yanai H. Propofol reduces the incidence of emergence agitation in preschool-aged children as well as in school-aged children: a comparison with sevoflurane. J Anesth 2007; 21: 19-23
27. Cohen IT, Finkel JC, Hannallah RS, Hummer KA, Patel KM. Rapid emergence does not explain agitation following sevoflurane anaesthesia in infants and children: a comparison with propofol. Paediatr Anaesth 2003; 13: 63-67
28. Viitanen H, Tarkkila P, Mennander S, Viitanen M, Annila P. Sevoflurane-maintained anesthesia induced with propofol or sevoflurane in small children: induction and recovery characteristics. Can J Anaesth 1999; 46: 21-28
29. Tsai PS, Hsu YW, Lin CS, Ko YP, Huang CJ. Ketamine but not propofol provides additional effects on attenuating sevofluraneinduced emergence agitation in midazolam premedicated pediatric patients. Paediatr Anaesth 2008; 18: 1114-1115
30. Aouad MT, Yazbeck-Karam VG, Nasr VG, El-Khatib MF, Kanazi GE, Bleik JH. A single dose of propofol at the end of surgery for the prevention of emergence agitation in children undergoing strabismus surgery during sevoflurane anesthesia. Anesthesiology 2007; 107: 733-738
31. Abu-Shahwan I. Effect of propofol on emergence behavior in children after sevoflurane general anesthesia. Paediatr Anaesth 2008; 18: 55-59
32. Ozdemir Kol I, Egilmez H, Kaygusuz K, Gursoy S, Mimaroglu C. Open-label, prospective, randomized comparison of propofol and sevoflurane for laryngeal mask anesthesia for magnetic resonance imaging in pediatric patients. Clin Ther 2008; 30: 175-181
33. Galinkin JL, Fazi LM, Cuy RM, et al. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 2000; 93: 1378-1383
34. Finkel JC, Cohen IT, Hannallah RS, et al. The effect of intranasal fentanyl on the emergence characteristics after sevoflurane anesthesia in children undergoing surgery for bilateral myringotomy tube placement. Anesth Analg 2001; 92: 1164-1168
35. Cravero JP, Beach M, Thyr B, Whalen K. The effect of small dose fentanyl on the emergence characteristics of pediatric patients after sevoflurane anesthesia without surgery. Anesth Analg 2003; 97: 364-367
36. Demirbilek S, Togal T, Cicek M, Aslan U, Sizanli E, Ersoy MO. Effects of fentanyl on the incidence of emergence agitation in children receiving desflurane or sevoflurane anaesthesia. Eur J Anaesthesiol 2004; 21: 538-542
37. Binstock W, Rubin R, Bachman C, Kahana M, McDade W, Lynch JP. The effect of premedication with OTFC, with or without ondansetron, on postoperative agitation, and nausea and vomiting in pediatric ambulatory patients. Paediatr Anaesth 2004; 14: 759-767
38. Kararmaz A, Kaya S, Turhanoglu S, Ozyilmaz MA. Oral ketamine premedication can prevent emergence agitation in children after desflurane anaesthesia. Paediatr Anaesth 2004; 14: 477-482
39. Dalens BJ, Pinard AM, Letourneau DR, Albert NT, Truchon RJ. Prevention of emergence agitation after sevoflurane anesthesia for pediatric cerebral magnetic resonance imaging by small doses of ketamine or nalbuphine administered just before discontinuing anesthesia. Anesth Analg 2006; 102: 1056-1061
40. Abu-Shahwan I, Chowdary K. Ketamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anesthesia. Paediatr Anaesth 2007; 17: 846-850
41. Shukry M, Clyde MC, Kalarickal PL, Ramadhyani U. Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia? Paediatr Anaesth 2005; 15: 1098-1104
42. Isik B, Arslan M, Tunga AD, Kurtipek O. Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery. Paediatr Anaesth 2006; 16: 748-753
43. Ibacache ME, Munoz HR, Brandes V, Morales AL. Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children. Anesth Analg 2004; 98: 60-63
44. Malviya S, Voepel-Lewis T, Ramamurthi RJ, Burke C, Tait AR. Clonidine for the prevention of emergence agitation in young children: efficacy and recovery profile. Paediatr Anaesth 2006; 16: 554-559
45. Lankinen U, Avela R, Tarkkila P. The prevention of emergence agitation with tropisetron or clonidine after sevoflurane anesthesia in small children undergoing adenoidectomy. Anesth Analg 2006; 102: 1383-1386
46. Tesoro S, Mezzetti D, Marchesini L, Peduto VA. Clonidine treatment for agitation in children after sevoflurane anesthesia. Anesth Analg 2005; 101: 1619-1622
47. Kulka PJ, Bressem M, Tryba M. Clonidine prevents sevoflurane-induced agitation in children. Anesth Analg 2001; 93: 335-338
48. Guler G, Akin A, Tosun Z, Ors S, Esmaoglu A, Boyaci A. Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy. Paediatr Anaesth 2005; 15: 762-766
49. Bock M, Kunz P, Schreckenberger R, Graf BM, Martin E, Motsch J. Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children. Br J Anaesth 2002; 88: 790-796
50. Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics. Acta Anaesthesiol Scand 2009; 53: 251-256
51. Araki H, Fujiwara Y, Shimada Y. Effect of flumazenil on recovery from sevoflurane anesthesia in children premedicated with oral midazolam before undergoing herniorrhaphy with or without caudal analgesia. J Anesth 2005; 19: 204-207
52. Davis PJ, Greenberg JA, Gendelman M, Fertal K. Recovery characteristics of sevoflurane and halothane in preschool-aged children undergoing bilateral myringotomy and pressure equalization tube insertion. Anesth Analg 1999; 88: 34-38
53. Cohen IT, Joffe D, Hummer K, Soluri A. Ondansetron oral disintegrating tablets: acceptability and efficacy in children undergoing adenotonsillectomy. Anesth Analg 2005; 101: 59-63
54. Veyckemans F. Excitation phenomena during sevoflurane anaesthesia in children. Curr Opin Anaesthesiol 2001; 14: 339-343
55. Kain ZN, Caldwell-Andrews AA, Maranets I, et al. Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors. Anesth Analg 2004; 99: 1648-1654
56. Arai YC, Ito H, Kandatsu N, Kurokawa S, Kinugasa S, Komatsu T. Parental presence during induction enhances the effect of oral midazolam on emergence behavior of children undergoing general anesthesia. Acta Anaesthesiol Scand 2007; 51: 858-861
57. da Conceição MJ, Bruggemann DACD, Carneiro Leao C. Effect of an intravenous single dose of ketamine on postoperative pain in tonsillectomy patients. Paediatr Anaesth 2006; 16: 962-967
58. Erhan OL, Goksu H, Alpay C, Bestas A. Ketamine in posttonsillectomy pain. Int J Pediatr Otorhinolaryngol 2007; 71: 735-739
59. Reimer EJ, Dunn GS, Montgomery CJ, Sanderson PM, Scheepers LD, Merrick PM. The effectiveness of clonidine as an analgesic in paediatric adenotonsillectomy. Can J Anaesth 1998; 45: 1162-1167
60. Tripi PA, Palmer JS, Thomas S, Elder JS. Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial. J Urol 2005; 174: 1081-1083
61. Nishina K, Mikawa K. Clonidine in paediatric anaesthesia. Curr Opin Anaesthesiol 2002; 15: 309-316
62. Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology 2004; 100: 1138-1145