Investigation of the involvement of P-glycoprotein and multidrug resistance-associated protein 2 in the efflux of ximelagatran and its metabolites by using short hairpin RNA knockdown in Caco-2 cells

Drug Metabolism and Disposition

Volumn 38, Issue 3, 2010, Pages 491-497

  Darnell, Malin ^a,b   Karlsson, Johan E ^a   Owen, Albert ^c   Hidalgo, Ismael J ^c   Li, Jibin ^c   Zhang, Wei ^c   Andersson, Tommy B ^a,b  

^a ASTRAZENECA R AND D   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Absorption Systems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; GLYCOPROTEIN P; MELAGATRAN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; SHORT HAIRPIN RNA; XIMELAGATRAN;

APICAL MEMBRANE; ARTICLE; CELL MEMBRANE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSCYTOSIS;

AMIDINES; ANTICOAGULANTS; AZETIDINES; BENZYLAMINES; BIOTRANSFORMATION; CACO-2 CELLS; CELL POLARITY; DRUG INTERACTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INVERTED REPEAT SEQUENCES; LENTIVIRUS; MEMBRANE TRANSPORT MODULATORS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P-GLYCOPROTEIN; RNA, MESSENGER; THROMBIN;

EID: 76749153917     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029967     Document Type: Article

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