Antimalarial activity of some plants traditionally used in Meru district of Kenya

Phytotherapy Research

Volumn 21, Issue 9, 2007, Pages 860-867

  Muthaura, C N ^a   Rukunga, G M ^a   Chhabra, S C ^b   Omar, S A ^a   Guantai, A N ^c   Gathirwa, J W ^a   Tolo, F M ^a   Mwitari, P G ^a   Keter, L K ^a   Kirira, P G ^a   Kimani, C W ^a   Mungai, G M ^d   Njagi, E N M ^b  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b KENYATTA UNIVERSITY   (Kenya)

^c UNIVERSITY OF NAIROBI   (Kenya)

^d INSTITUTE OF PRIMATE RESEARCH   (Kenya)

Author keywords

Antimalarial; Antiplasmodial; Plant extracts; Toxicity

Indexed keywords

ARTEMISININ; BOSCIA ANGUSTIFOLIA EXTRACT; CHLOROQUINE; CLERODENDRUM ERIOPHYLLUM EXTRACT; CLUTIA ABYSSINICA EXTRACT; FUERSTIA AFRICANA EXTRACT; LUDWIGIA ERECTA EXTRACT; METHANOL; OCOTEA USAMBARENSIS EXTRACT; PITTOSPORUM VIRIDIFLORUM EXTRACT; PLANT EXTRACT; SCHKUHRIA PINNATA EXTRACT; SPHAERANTHUS SUAVEOLENS EXTRACT; UNCLASSIFIED DRUG; VANGUERIA ACUTILOBA EXTRACT; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; FEMALE; IC 50; IN VITRO STUDY; KENYA; LD 50; MEDICINAL PLANT; MOLECULAR CLONING; MOUSE; NONHUMAN; PARASITEMIA; PHARMACOLOGICAL PARAMETERS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SINGLE DRUG DOSE; TRADITIONAL MEDICINE; VERO CELL;

ANIMALS; ANTIMALARIALS; FEMALE; KENYA; MALARIA; MEDICINE, AFRICAN TRADITIONAL; MICE; PARASITIC SENSITIVITY TESTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

ANIMALIA; CLERODENDRUM ERIOPHYLLUM; FUERSTIA AFRICANA; LUDWIGIA ERECTA; MUS; PITTOSPORUM VIRIDIFLORUM; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SCHKUHRIA PINNATA;

EID: 34548632089     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2170     Document Type: Article

References (41)

1. Alexeeff GV, Broadwin R, Liaw J, Dawson SV. 2002. Characterization of the LOAEL-to-NOAEL uncertainty factor for mild adverse effects from acute inhalation exposures. Regul Toxicol Pharmacol 36: 96-105.
2. Antindehou KK, Schmid C, Brun R, Kone MW, Traore D. 2004. Antitrypanosomal and antiplasmodial activity of medicinal plants from Cote d'Ivoire. J Ethnopharmacol 90: 221-227.
3. Azas N, Laurencin N, Delmas F et al. 2001. Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitol Res 88: 165-171.
4. Bashwira S, Hootele C, Tourwe D, Pepermans H, Laus G, Van Binst G. 1989. Cleromyrine I, a new cyclohexapeptide from Clerodendrum myricoides. Tetrahedron 45: 5845-5852.
5. Benoit-Vical T, Valentin A, Cournac V, Peliesier Y, Mallié M, Bastide JM. 1998. In vitro antiplasmodial activity of stem and root extracts of Nauclea latifolia (Rubiaceae). J Ethnopharmacol 61: 173-178.
6. Bjorkman A, Phillips-Howard PA. 1990. Drug resistant malaria: Mechanism of development and interferences for malaria control. J Trop Med Hyg 84: 323-324.
7. Capasso F. 1985. Medicinal plants: an approach to the study of naturally occurring drugs. J Ethnopharmamacol 3: 111-114.
8. Cepleanu F, Hamburger MO, Sordat B et al. 1994. Screening of tropical medicinal plants for molluscidal, larvicidal, fungicidal and cytotoxic activities and brine shrimp toxicity. Int J Pharmacog 32: 294-307.
9. Cimanga KDE, Bruyne T, Pieters I, Turger CA, Vlietinck AJ. 1997. In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta. J Nat Prod 60: 688-691.
10. Clarkson C, Vinesh JM, Neil RC et al. 2004. In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J Ethnopharmacol 92: 177-191.
11. Desjardins RE, Carfield C, Haynes Chulay J. 1979. Quantitative assessment of antimicrobial activity in vitro by a semi-automated microdilution technique. Antimicrob Agents Chemother 16: 710-718.
12. Dorin D, Le Roch K, Sallicandro P et al. 2001. Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum; biochemical properties and possible involvement in MAPK regulation. Eur J Biochem 268: 2600-2608.
13. Gakunju DM, Mberu EK, Dossaji SF et al. 1995. Potential antimalarial activity of the alkaloid nitidine isolated from a Kenyan herbal remedy. Antimicrob Agents Chemother 39: 2606-2609.
14. Gessler MC, Nkunya MHH, Chollet J, Heinrich M, Tanner M. 1995. Tanzanian medicinal plants used traditionally for the treatment of malaria: in vivo antimalarial and in vitro cytotoxic activities. Phytother Res 9: 504-508.
15. Gessler MC, Nkunya MHH, Mwasumbi LB, Heinrich M, Tanner M. 1994. Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop 56: 65-77.
16. Greenwood B, Mutabingwa T. 2002. Malaria in 2002. Acta Trop 415: 670-672.
17. Hien TT, White NJ. 1993. Quinghaosu. Lancet 341: 603-608.
18. Kirby GC, Paine A, Warhurst DC, Noamese BK, Phillipson JD. 1995. In vitro and in vivo antimalarial activity of cryptolepine, a plant derived indoloquinoline. Phytotherapy Research 9: 359-363.
19. Koch A, Tamez P, Pezzuto J, Soejarto D. 2005. Evaluation of plants used for antimalarial treatment by the Masai of Kenya. J Ethnopharmacol 101: 95-99.
20. Kokwaro JO. 1993. Medicinal Plants of East Africa. East African Literature Bureau: Nairobi.
21. Kraft CK, Jenett-Siems K, Siems K et al. 2003. Herbal remedies traditionally used against malaria. In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe. Phytother Res 17: 123-128.
22. Kurokawa M, Hozumi T, Tsurita M, Kadota S, Namba T, Shiraki K. 2001. Biological characterization of Eugeniin as an anti-Herpes Virus Type 1 compound in vitro and in vivo. J Pharmacol Exp Ther 297: 372-379.
23. Likhitwitayawuid K, Angerhofer CK, Chai H, Pezzuto JM, Cordell GA, Ruangrungsi N. 1993. Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile. J Nat Prod 56: 1331-1338.
24. Muregi FW, Chhabra SC, Njagi ENM et al. 2004. Antiplasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine. Phytother Res 18: 379-384.
25. Peters W, Portus JH, Robinson BL. 1975. The chemotherapy of rodent malaria XX11. The value of drug resistance strains of Plasmodium berghei in screening for blood schizonticidal activity. Ann Trop Med Parasitol 69: 155-165.
26. Phillipson JD, Wright CW. 1991. Can ethnopharmacology contribute to the development of anti-malarial agents? J Ethnopharmacol 32: 155-165.
27. Rasoanaivo P, Petitjean A, Ratsimamanga-Urverg S, Rakato-Ratsimamanga A. 1992. Medicinal plants used to treat malaria in Madagascar. J Ethnopharmacol 37: 117-127.
28. Seo Y, Berger JM, Hoch J et al. 2002. A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rain forest. J Nat Prod 65: 65-68.
29. Schlichtherle M, Wahlgrer M, Perlmann H, Scherf A (eds). 2000. Methods in Malaria Research, 3rd edn. MR4/ATCC, Manassas, Virginia, 1-74.
30. Sixsmith DG, Watkins WM, Chuly JD, Spencer HC. 1984. In vitro anti-malarial activity of tetrahydrofolate dehydrogenase inhibitors. Am J Trop Med Hyg 33: 772-776.
31. Thompson EB. 1985. Drug Bioscreening: Fundamentals of Drug Evaluation Techniques in Pharmacology. Graceway Publishing Company, Flushing: New York; 76-81.
32. Tona L, Mesia K, Ngimbi NP et al. 2001. In vivo anti-malarial activity of Cassia occindentalis, Morinda morindoides and Phyllanthus niruri. Am J Trop Med Hyg 95: 47-57.
33. Trager W, Jensen JB. 1976. Human malaria parasites in continuous culture. Science 193: 673-675.
34. Twaij HAA, Kery A, Al Khazraji NK. 1983. Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala. J Ethnopharmacol 9: 299-314.
35. Vonthron-Senecheau C, Weniger B, Quattara M et al. 2003. In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected Ivorian plants. J Ethnopharmacol 87: 21-25.
36. Wanyoike GN, Chhabra SC, Lang'at-Thoruwa CC, Omar SA. 2004. Brine shrimp toxicity and antiplasmodial activity of five Kenyan medicinal plants. J Ethnopharmacol 90: 129-133.
37. Weenen H, Nkunya MHH, Bray DH, Mwasubi LB, Kinabo LS, Kilimali VA. 1990. Antimalarial activity of Tanzanian medicinal plants. Planta Med 56: 368-370.
38. Wellems T, Plowe C. 2001. Chloroquine-resistance malaria. J Infect Dis 184: 770-776.
39. Wernsdorfer WH. 1994. Epidemiology of drug resistant in malaria. Acta Trop 56: 143-156.
40. WHO. 1984. Technical Report Series NO. 711. Advances in Malaria Chemotherapy. World Health Organization: Geneva, 91-100.
41. WHO. 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94(Suppl. 51): 36-37.