Bioavailability assessment of ketoprofen incorporated in gelled self-emulsifying formulation: A technical note

AAPS PharmSciTech

Volumn 6, Issue 1, 2005, Pages E9-E13

  Patil, Pradeep R ^a   Praveen, S ^b   Shobha Rani, R H ^b   Paradkar, Anant R ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^b AL AMEEN COLLEGE OF PHARMACY   (India)

Author keywords

AAPS PharmSciTech; Halofantrine; Idebenone; Ketoprofen; Naproxen

Indexed keywords

EMULSIFYING AGENT; KETOPROFEN;

ADULT; ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BIOAVAILABILITY; BLOOD; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; GEL; HUMAN; MALE; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CONFIDENCE INTERVALS; CROSS-OVER STUDIES; EMULSIFYING AGENTS; GELS; HUMANS; KETOPROFEN; MALE;

EID: 33644813455     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt060104     Document Type: Article

References (22)

1. Charman SA, Charman WN, Rogge MC, Wilson TD, Pouton CW. Self-emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of an investigational lipophilic compound.Pharm Res. 1992;9:87–93. DOI: 10.1023/A:1018987928936
2. Itoh K, Tozuka Y, Oguchi T, Yamamoto K. Improvement of physicochemical properties of N-4472 part I formulation design by using self-microemulsifying system.Int J Pharm. 2002;238:153–160.
3. Kim H-J, Yoon KA, Hahn M, Park E-S, Chi S-C. Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone.Drug Dev Ind Pharm. 2000;26:523–529. DOI: 10.1081/DDC-100101263
4. Kommuru TR, Gurley B, Khan MA, Reddy IK. Self-emulsifying drug deliverly systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment.Int J Pharm. 2001;212:233–246. DOI: 10.1016/S0378-5173(00)00614-1
5. Khoo S-M, Humberstone AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine.Int J Pharm. 1998; 167:155–164. DOI: 10.1016/S0378-5173(98)00054-4
6. Gao ZG, Choi HG, Shin HJ, et al. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporine A.Int J Pharm. 1998: 167:75–86. DOI: 10.1016/S0378-5173(97)00325-6
7. PDR staff.Physician's Desk Reference, 56th ed. Montvale, NJ: Medical Economic Company; 2002.
8. Anderson T, Bredberg E, Lagerstrom PO, Naesdal J, Wilson I. Lack of drug-drug interaction between three different non-steroidal anti-inflammatory drugs and omeprazole.Eur J Clin Pharmacol. 1998;54:399–404. DOI: 10.1007/s002280050482
9. Upton RA, Williams RL, Guentert TW, Buskin JN, Reigelman S. Ketoprofen pharmacokinetics and bioavailability based on an improved sensitive and specific assay.Eur J Clin Pharmacol. 1981;20:123–127. DOI: 10.1007/BF00607149
10. Bannwarth B, Lapieque F, Netter P, et al. The effect of food on the systemic availability of ketoprofen.Eur J Clin Pharmacol. 1988;33:643–645. DOI: 10.1007/BF00542503
11. Vergote GJ, Vervaet C, Van Driessche I, et al. An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen.Int J Pharm. 2001;219:81–87. DOI: 10.1016/S0378-5173(01)00628-7
12. Yamada T, Onishi H, Machida Y. Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose.J Control Release. 2001;219:271–282. DOI: 10.1016/S0168-3659(01)00399-6
13. El-Kamel AH, Sokar MS, Al Gamal SS, Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system.Int J Pharm. 2001;219:13–21. DOI: 10.1016/S0378-5173(01)00574-9
14. Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs.Eur J Pharm Biopharm. 2000;50:179–188. DOI: 10.1016/S0939-6411(00)00089-8
15. MacGregor KJ, Embleton JK, Lacy JE, et al. Influence of lipolysis on drug absorption from gastro-intestinal tract.Adv Drug Deliv Rev. 1997;50:33–46. DOI: 10.1016/S0169-409X(96)00489-9
16. Humberstone AJ, Charmann WN. Lipid-based vehicles for the oral delivery of poorly water-soluble drugs.Adv Drug Deliv Rev. 1997;25:103–128. DOI: 10.1016/S0169-409X(96)00494-2
17. Patil P, Joshi P, Paradkar A. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen.AAPS PharmSci Tech. 2004;5:E42. DOI: 10.1208/pt050342
18. Satterwhite JH, Boudinot DF. High-performance liquid chromatographic determination of ketoprofen and naproxen in rat plasma.J Chromatogr. 1998;25:444–449.
19. Gibaldi M, Perrier D.Pharmacokinetics, 2nd ed. New York, NY: Marcel Dekker; 1982:145–149.
20. FDA/CDER Guidance Document page. Bioavailability and bioequivalence studies for orally administered drug products-general considerations. Food and Drug Administration Web site. Available at: http://www.fda.gov/cder/guidance. Accessed October 2002.
21. Raghavan SR, Walls HJ, Khan SA. Rheology of silica dispersions in organic liquids: new evidence for salvation forces dictated by hydrogen bonding.Langmuir. 2000b;16:7920–7930. DOI: 10.1021/la991548q
22. Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco 2 cells by inhibition of an apically polarized efflux system.Pharm Res. 1996;13:528–534. DOI: 10.1023/A:1016033702220