The inhibitory effect of rivastigmine and galantamine on choline transport in brain capillary endothelial cells

Biomolecules and Therapeutics

Volumn 18, Issue 1, 2010, Pages 65-70

  Lee, Na Young ^a   Kang, Young Sook ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Blood brain barrier; Choline transport; Galantamine; Rivastigmine; TR BBB cells

Indexed keywords

CHOLINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DONEPEZIL; GALANTAMINE; RIVASTIGMINE;

AMINE TRANSPORT; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL STRAIN TR BBB; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; EFFUSION; IC 50; ISOTOPE LABELING; NONHUMAN; RAT;

RATTUS;

EID: 76749119338     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2010.18.1.065     Document Type: Article

References (25)

1. Allen, D. D., Lockman, P. R., Roder, K. E., Dwoskin, L. P. and Crooks, P. A. (2003). Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. J. Pharmacol. Exp. Ther. 304, 1268-1274.
2. Allen, D. D. and Smith, Q. R. (2001). Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique. J. Neurochem. 76, 1032-1041.
3. Cohen, B. M., Renshaw, P. F., Stoll, A. L., Wurtman, R. J., Yurgelun-Todd, D. and Babb, S. M. (1995). Decreased brain choline uptake in older adults: an in vivo proton magnetic resonance spectroscopy study. J. Am. Med. Assoc. 274, 902-907.
4. Cornford, E. M., Braun, L. D. and Oldendorf, W. H. (1978). Carrier mediated blood-brain barrier transport of choline and certain analogs. J. Neurochem. 30, 299-308.
5. Hosoya, K. I., Ohtsuki, S. and Terasaki, T. (2002). Recent advances in the brain-to-blood efflux transport across the blood-brain barrier. Int. J. Pharm. 248, 15-29.
6. Hosoya, K. I., Takashima, T., Tetsuka, K., Nagura, T., Ohtsuki, S., Takanaga, H., Ueda, M., Yanai, N., Obinata, M. and Terasaki, T. (2000). mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines, a new in vitro BBB model for drug targeting. J. Drug Target. 8, 357-370.
7. Jann, M. W., Shirley, K. L. and Small, G. W. (2002). Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin. Pharmacokinet. 41, 719-739.
8. Kang, Y. S., Terasaki, T., Ohnishi, T. and Tsuji, A. (1990). In vivo and in vitro evidence for a common carrier mediated transport of choline and basic drugs through the blood-brain barrier. J. Pharmacobiodyn. 13, 353-360.
9. Kang, Y. S., Lee, K. E., Lee, N. Y. and Terasaki, T. (2005). Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB). Arch. Pharm. Res. 28, 443-450.
10. Kang, Y. S., Ohtsuki, S., Takanaga, H., Tomi, M., Hosoya, K. and Terasaki, T. (2002). Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity. J. Neurochem. 83, 1188-1195.
11. Kim, M. H., Maeng, H. J., Yu, K. H., Lee, K. R., Tsuruo, T., Kim, D. D., Shim, C. K. and Chung, S. J. (2009). Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain. J. Pharm. Sci. 99, 1548-1566.
12. Lee, N. Y. and Kang, Y. S. (2006). In vivo brain-to-blood efflux transport of choline at the blood-brain barrier. J. Appl. Pharmacol. 14, 45-49.
13. Lee, N. Y. and Kang, Y. S. (2008). The efflux transport of choline through blood-brain barrier is inhibited by Alzheimer's disease therapeutics. Biomol. & Ther. 16, 179-183.
14. Matsui, K., Mishima, M., Nagai, Y., Yuzuriha, T. and Yoshimura, T. (1999). Absorption, Distribution, Metabolism, and Excretion of Donepezil (Aricept) after a Single Oral Administration to Rat. Drug Metab. Dispos. 27, 1406-1414.
15. McNally, W. P., Pool, W. F., Sinz, M. W., Dehart, P., Ortwine, D. F., Huang, C. C., Chang, T. and Woolf, T. F. (1996). Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens; Evidence for accumulation of tacrine in brain tissue. Drug Metab. Dispos. 24, 628-633.
16. Metting, T. L., Burgio, D. E., Terry, A. V., Beach, J. W., Mccurdy, C. R. and Allen, D. D. (1998). Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: implications for potential vector-mediated brain drug delivery. Neurosci. Let. 258, 25-28.
17. Murakami, H., Takanaga, H., Matsuo, H., Ohtani, H. and Sawada, Y. (2000). Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique. Am. J. Physiol. Heart Circ. Physiol. 279, H1022-1028.
18. Ohtsuki, S. and Terasaki T. (2007). Contribution of carriermediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24, 1745-1758.
19. Pardridge, W. M. (1988). Recent advances in blood-brain barrier transport. Annu. Rev. Pharmacol. Toxicol. 28, 25-39.
20. Polinsky, R. J. (1998). Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin. Ther. 20, 634-647.
21. Sawada, N., Takanaga, H., Matsuo, H., Naito, M., Tsuruo, T. and Sawada, Y. (1999). Choline uptake by mouse brain capillary endothelial cells in culture. J. Pharm. Pharmacol. 51, 847-852.
22. Sung, J. H., Yu, K. H., Park, J. S., Tsuruo, T., Kim, D. D., Shim, C. K., Chung, S. J. (2005). Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport. Drug. Metab. Dispos. 33, 440-448.
23. Takanaga, H., Tokuda, N., Ohtsuki, S., Hosoya, K. and Terasaki, T. (2002). ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-toblood efflux transport for L-proline. Mol. Pharmacol. 61, 1289-1296.
24. Terasaki, T., Ohtsuki, S., Hori, S., Takanaga, H., Nakashima, E. and Hosoya, K. (2003). New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov. Today. 8, 944-954.
25. Tiseo, P. J., Rogers, S. L. and Friedhoff, L. T. (1998). Pharmacokinetic and pharmacodynamic profile of donepezil HCl following evening administration. Br. J. Clin. Pharmacol. 46, 13-18.