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Volumn 17, Issue 2, 2010, Pages 202-216

Cellular effects of oncolytic viral therapy on the glioblastoma microenvironment

Author keywords

Apoptotic index; G207; Glioblastoma xenograft; Microvessel density; Oncolytic herpes viral vector; Proliferation index

Indexed keywords

CD68 ANTIGEN; HERPESVIRUS VECTOR; ONCOLYTIC HERPES VIRUS;

EID: 76749119314     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.130     Document Type: Article
Times cited : (18)

References (52)
  • 1
    • 0029023868 scopus 로고
    • Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas
    • Mineta T, Rabkin SD, Yazaki T, Hunter WD, Martuza RL. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat Med 1995; 1: 938-943.
    • (1995) Nat Med , vol.1 , pp. 938-943
    • Mineta, T.1    Rabkin, S.D.2    Yazaki, T.3    Hunter, W.D.4    Martuza, R.L.5
  • 2
    • 0023880185 scopus 로고
    • Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: Isolation and characterization of an ICP6 lacZ insertion mutant
    • Goldstein DJ, Weller SK. Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant. J Virol 1988; 62: 196-205.
    • (1988) J Virol , vol.62 , pp. 196-205
    • Goldstein, D.J.1    Weller, S.K.2
  • 3
    • 0024464324 scopus 로고
    • A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactiva-table latent infections of mice and for replication in mouse cells
    • Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK et al. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactiva-table latent infections of mice and for replication in mouse cells. Virology 1989; 173: 276-283.
    • (1989) Virology , vol.173 , pp. 276-283
    • Jacobson, J.G.1    Leib, D.A.2    Goldstein, D.J.3    Bogard, C.L.4    Schaffer, P.A.5    Weller, S.K.6
  • 4
    • 0032789088 scopus 로고    scopus 로고
    • Attenuated, replication-competent herpes simplex virus type 1 mutant G207: Safety evaluation of intracerebral injection in nonhuman primates
    • Hunter WD, Martuza RL, Feigenbaum F, Todo T, Mineta T, Yazaki T et al. Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates. J Virol 1999; 73: 6319-6326.
    • (1999) J Virol , vol.73 , pp. 6319-6326
    • Hunter, W.D.1    Martuza, R.L.2    Feigenbaum, F.3    Todo, T.4    Mineta, T.5    Yazaki, T.6
  • 5
    • 0034035628 scopus 로고    scopus 로고
    • Attenuated, replication-competent herpes simplex virus type 1 mutant G207: Safety evaluation in mice
    • Sundaresan P, Hunter WD, Martuza RL, Rabkin SD. Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice. J Virol 2000; 74: 3832-3841.
    • (2000) J Virol , vol.74 , pp. 3832-3841
    • Sundaresan, P.1    Hunter, W.D.2    Martuza, R.L.3    Rabkin, S.D.4
  • 6
    • 12944315014 scopus 로고    scopus 로고
    • Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase i trial
    • Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD et al. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Therapy 2000; 7: 867-874.
    • (2000) Gene Therapy , vol.7 , pp. 867-874
    • Markert, J.M.1    Medlock, M.D.2    Rabkin, S.D.3    Gillespie, G.Y.4    Todo, T.5    Hunter, W.D.6
  • 7
    • 58149237728 scopus 로고    scopus 로고
    • Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM
    • Markert JM, Liechty PG, Wang W, Gaston S, Braz E, Karrasch M et al. Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM. Mol Ther 2009; 17: 199-207.
    • (2009) Mol Ther , vol.17 , pp. 199-207
    • Markert, J.M.1    Liechty, P.G.2    Wang, W.3    Gaston, S.4    Braz, E.5    Karrasch, M.6
  • 9
    • 0035933088 scopus 로고    scopus 로고
    • Oncolytic herpes simplex virus vector with enhanced MHC class i presentation and tumor cell killing
    • Todo T, Martuza RL, Rabkin SD, Johnson PA. Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing. Proc Natl Acad Sci USA 2001; 98: 6396-6401.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6396-6401
    • Todo, T.1    Martuza, R.L.2    Rabkin, S.D.3    Johnson, P.A.4
  • 10
    • 31544455030 scopus 로고    scopus 로고
    • Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy
    • Ino Y, Saeki Y, Fukuhara H, Todo T. Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy. Clin Cancer Res 2006; 12: 643-652.
    • (2006) Clin Cancer Res , vol.12 , pp. 643-652
    • Ino, Y.1    Saeki, Y.2    Fukuhara, H.3    Todo, T.4
  • 11
    • 33846707286 scopus 로고    scopus 로고
    • Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombos-pondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide
    • Aghi M, Rabkin SD, Martuza RL. Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombos-pondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide. Cancer Res 2007; 67: 440-444.
    • (2007) Cancer Res , vol.67 , pp. 440-444
    • Aghi, M.1    Rabkin, S.D.2    Martuza, R.L.3
  • 12
    • 33845295448 scopus 로고    scopus 로고
    • Dominant-negative fibroblast growth factor receptor expression enhances antitumoral potency of oncolytic herpes simplex virus in neural tumors
    • Liu TC, Zhang T, Fukuhara H, Kuroda T, Todo T, Canron X et al. Dominant-negative fibroblast growth factor receptor expression enhances antitumoral potency of oncolytic herpes simplex virus in neural tumors. Clin Cancer Res 2006; 12: 6791-6799.
    • (2006) Clin Cancer Res , vol.12 , pp. 6791-6799
    • Liu, T.C.1    Zhang, T.2    Fukuhara, H.3    Kuroda, T.4    Todo, T.5    Canron, X.6
  • 13
    • 33751036062 scopus 로고    scopus 로고
    • Oncolytic HSV armed with platelet factor 4, an antiangio-genic agent, shows enhanced efficacy
    • Liu TC, Zhang T, Fukuhara H, Kuroda T, Todo T, Martuza RL et al. Oncolytic HSV armed with platelet factor 4, an antiangio-genic agent, shows enhanced efficacy. Mol Ther 2006; 14: 789-797.
    • (2006) Mol Ther , vol.14 , pp. 789-797
    • Liu, T.C.1    Zhang, T.2    Fukuhara, H.3    Kuroda, T.4    Todo, T.5    Martuza, R.L.6
  • 14
    • 30344448580 scopus 로고    scopus 로고
    • Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication
    • Aghi M, Rabkin S, Martuza RL. Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J Natl Cancer Inst 2006; 98: 38-50.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 38-50
    • Aghi, M.1    Rabkin, S.2    Martuza, R.L.3
  • 17
    • 0027981988 scopus 로고
    • Collagens, integrins and the mesenchymal drift in glioblastomas: A comparison of biopsy specimens, spheroid and early monolayer cultures
    • Paulus W, Huettner C, Tonn JC. Collagens, integrins and the mesenchymal drift in glioblastomas: a comparison of biopsy specimens, spheroid and early monolayer cultures. Int J Cancer 1994; 58: 841-846.
    • (1994) Int J Cancer , vol.58 , pp. 841-846
    • Paulus, W.1    Huettner, C.2    Tonn, J.C.3
  • 20
    • 0025392973 scopus 로고
    • Multi-cellular tumor spheroids from human gliomas maintained in organ culture
    • Bjerkvig R, Tonnesen A, Laerum OD, Backlund EO. Multi-cellular tumor spheroids from human gliomas maintained in organ culture. J Neurosurg 1990; 72: 463-475.
    • (1990) J Neurosurg , vol.72 , pp. 463-475
    • Bjerkvig, R.1    Tonnesen, A.2    Laerum, O.D.3    Backlund, E.O.4
  • 22
    • 16344368248 scopus 로고    scopus 로고
    • Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts
    • Huszthy PC, Svendsen A, Wilson JM, Kotin RM, Lonning PE, Bjerkvig R et al. Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Hum Gene Ther 2005; 16: 381-392.
    • (2005) Hum Gene Ther , vol.16 , pp. 381-392
    • Huszthy, P.C.1    Svendsen, A.2    Wilson, J.M.3    Kotin, R.M.4    Lonning, P.E.5    Bjerkvig, R.6
  • 23
    • 33749365644 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma
    • Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R et al. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. J Gene Med 2006; 8: 1131-1140.
    • (2006) J Gene Med , vol.8 , pp. 1131-1140
    • Thorsen, F.1    Afione, S.2    Huszthy, P.C.3    Tysnes, B.B.4    Svendsen, A.5    Bjerkvig, R.6
  • 24
    • 33750565442 scopus 로고    scopus 로고
    • Protein disulfide isomerase expression is related to the invasive properties of malignant glioma
    • Goplen D, Wang J, Enger PO, Tysnes BB, Terzis AJ, Laerum OD et al. Protein disulfide isomerase expression is related to the invasive properties of malignant glioma. Cancer Res 2006; 66: 9895-9902.
    • (2006) Cancer Res , vol.66 , pp. 9895-9902
    • Goplen, D.1    Wang, J.2    Enger, P.O.3    Tysnes, B.B.4    Terzis, A.J.5    Laerum, O.D.6
  • 25
    • 40949124671 scopus 로고    scopus 로고
    • Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma
    • Huszthy PC, Goplen D, Thorsen F, Immervoll H, Wang J, Gutermann A et al. Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma. Clin Cancer Res 2008; 14: 1571-1580.
    • (2008) Clin Cancer Res , vol.14 , pp. 1571-1580
    • Huszthy, P.C.1    Goplen, D.2    Thorsen, F.3    Immervoll, H.4    Wang, J.5    Gutermann, A.6
  • 26
    • 0027536915 scopus 로고
    • Ware J. von Willebrand factor
    • Ruggeri ZM, Ware J. von Willebrand factor. FASEB J 1993; 7: 308-316.
    • (1993) FASEB J , vol.7 , pp. 308-316
    • Ruggeri, Z.M.1
  • 27
    • 67651165115 scopus 로고    scopus 로고
    • Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy
    • Huszthy PC, Giroglou T, Tsinkalovsky O, Euskirchen P, Skaftnesmo KO, Bjerkvig R et al. Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy. PLoS One 2009; 4: e6314.
    • (2009) PLoS One , vol.4
    • Huszthy, P.C.1    Giroglou, T.2    Tsinkalovsky, O.3    Euskirchen, P.4    Skaftnesmo, K.O.5    Bjerkvig, R.6
  • 28
    • 0027483695 scopus 로고
    • The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL et al. The 'bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abboud, C.N.2    Whartenby, K.A.3    Packman, C.H.4    Koeplin, D.S.5    Moolten, F.L.6
  • 29
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: From the known and the unknown
    • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-322.
    • (2000) J Cell Physiol , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 30
    • 0032947907 scopus 로고    scopus 로고
    • Protein synthesis rate measured with L-[1-11C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas
    • Plaat B, Kole A, Mastik M, Hoekstra H, Molenaar W, Vaalburg W. Protein synthesis rate measured with L-[1-11C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas. Eur J Nucl Med 1999; 26: 328-332.
    • (1999) Eur J Nucl Med , vol.26 , pp. 328-332
    • Plaat, B.1    Kole, A.2    Mastik, M.3    Hoekstra, H.4    Molenaar, W.5    Vaalburg, W.6
  • 31
    • 42249098076 scopus 로고    scopus 로고
    • Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma
    • Ullrich R, Backes H, Li H, Kracht L, Miletic H, Kesper K et al. Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma. Clin Cancer Res 2008; 14: 2049-2055.
    • (2008) Clin Cancer Res , vol.14 , pp. 2049-2055
    • Ullrich, R.1    Backes, H.2    Li, H.3    Kracht, L.4    Miletic, H.5    Kesper, K.6
  • 33
    • 0036855323 scopus 로고    scopus 로고
    • Diagnostic and prognostic role of Ki67 immunostain-ing in human astrocytomas using four different antibodies
    • Torp SH. Diagnostic and prognostic role of Ki67 immunostain-ing in human astrocytomas using four different antibodies. Clin Neuropathol 2002; 21: 252-257.
    • (2002) Clin Neuropathol , vol.21 , pp. 252-257
    • Torp, S.H.1
  • 34
    • 0034652406 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 infection imposes a G(1)/S block in asynchronously growing cells and prevents G(1) entry in quiescent cells
    • Ehmann GL, McLean TI, Bachenheimer SL. Herpes simplex virus type 1 infection imposes a G(1)/S block in asynchronously growing cells and prevents G(1) entry in quiescent cells. Virology 2000; 267: 335-349.
    • (2000) Virology , vol.267 , pp. 335-349
    • Ehmann, G.L.1    McLean, T.I.2    Bachenheimer, S.L.3
  • 35
    • 0344995285 scopus 로고    scopus 로고
    • Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0
    • Hobbs 2nd WE, DeLuca NA. Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0. J Virol 1999; 73: 8245-8255.
    • (1999) J Virol , vol.73 , pp. 8245-8255
    • Hobbs Ii, W.E.1    Deluca, N.A.2
  • 36
    • 0035950918 scopus 로고    scopus 로고
    • Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions
    • Song B, Yeh KC, Liu J, Knipe DM. Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions. Virology 2001; 290: 320-328.
    • (2001) Virology , vol.290 , pp. 320-328
    • Song, B.1    Yeh, K.C.2    Liu, J.3    Knipe, D.M.4
  • 37
    • 0022620632 scopus 로고
    • Malignant astrocytic neoplasms: Classification, pathologic anatomy, and response to treatment
    • Burger PC. Malignant astrocytic neoplasms: classification, pathologic anatomy, and response to treatment. Semin Oncol 1986; 13: 16-26.
    • (1986) Semin Oncol , vol.13 , pp. 16-26
    • Burger, P.C.1
  • 38
    • 0024557181 scopus 로고
    • Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67
    • Deckert M, Reifenberger G, Wechsler W. Determination of the proliferative potential of human brain tumors using the monoclonal antibody Ki-67. J Cancer Res Clin Oncol 1989; 115: 179-188.
    • (1989) J Cancer Res Clin Oncol , vol.115 , pp. 179-188
    • Deckert, M.1    Reifenberger, G.2    Wechsler, W.3
  • 39
    • 0026719118 scopus 로고
    • Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours
    • Jaros E, Perry RH, Adam L, Kelly PJ, Crawford PJ, Kalbag RM et al. Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. Br J Cancer 1992; 66: 373-385.
    • (1992) Br J Cancer , vol.66 , pp. 373-385
    • Jaros, E.1    Perry, R.H.2    Adam, L.3    Kelly, P.J.4    Crawford, P.J.5    Kalbag, R.M.6
  • 41
    • 33845985638 scopus 로고    scopus 로고
    • Apoptosis during herpes simplex virus infection
    • Nguyen ML, Blaho JA. Apoptosis during herpes simplex virus infection. Adv Vir Res 2007; 69: 67-97.
    • (2007) Adv Vir Res , vol.69 , pp. 67-97
    • Nguyen, M.L.1    Blaho, J.A.2
  • 42
    • 4344691959 scopus 로고    scopus 로고
    • Caspases IAPs and Smac/DIABLO: Mechanisms from structural biology
    • Shiozaki EN, Shi Y. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem Sci 2004; 29: 486-494.
    • (2004) Trends Biochem Sci , vol.29 , pp. 486-494
    • Shiozaki, E.N.1    Shi, Y.2
  • 43
    • 0026533363 scopus 로고
    • Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells
    • Cai W, Schaffer PA. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells. J Virol 1992; 66: 2904-2915.
    • (1992) J Virol , vol.66 , pp. 2904-2915
    • Cai, W.1    Schaffer, P.A.2
  • 44
    • 0031947861 scopus 로고    scopus 로고
    • Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins
    • Samaniego LA, Neiderhiser L, DeLuca NA. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J Virol 1998; 72: 3307-3320.
    • (1998) J Virol , vol.72 , pp. 3307-3320
    • Samaniego, L.A.1    Neiderhiser, L.2    Deluca, N.A.3
  • 46
    • 48349119172 scopus 로고    scopus 로고
    • Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61
    • Kurozumi K, Hardcastle J, Thakur R, Shroll J, Nowicki M, Otsuki A et al. Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther 2008; 16: 1382-1391.
    • (2008) Mol Ther , vol.16 , pp. 1382-1391
    • Kurozumi, K.1    Hardcastle, J.2    Thakur, R.3    Shroll, J.4    Nowicki, M.5    Otsuki, A.6
  • 47
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangio-blastoma-like vessels by VEGF withdrawal
    • Benjamin LE, Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangio-blastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA 1997; 94: 8761-8766.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 48
    • 35148871720 scopus 로고    scopus 로고
    • Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses
    • Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y et al. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res 2007; 67: 9398-9406.
    • (2007) Cancer Res , vol.67 , pp. 9398-9406
    • Fulci, G.1    Dmitrieva, N.2    Gianni, D.3    Fontana, E.J.4    Pan, X.5    Lu, Y.6
  • 49
    • 0028339366 scopus 로고
    • Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune ence-phalomyelitis
    • Bauer J, Sminia T, Wouterlood FG, Dijkstra CD. Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune ence-phalomyelitis. J Neurosci Res 1994; 38: 365-375.
    • (1994) J Neurosci Res , vol.38 , pp. 365-375
    • Bauer, J.1    Sminia, T.2    Wouterlood, F.G.3    Dijkstra, C.D.4
  • 50
    • 0021969667 scopus 로고
    • The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macro-phage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3
    • Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macro-phage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985; 54: 589-599.
    • (1985) Immunology , vol.54 , pp. 589-599
    • Dijkstra, C.D.1    Dopp, E.A.2    Joling, P.3    Kraal, G.4
  • 52
    • 0035266284 scopus 로고    scopus 로고
    • Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model
    • Kuriyama N, Kuriyama H, Julin CM, Lamborn KR, Israel MA. Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model. Cancer Res 2001; 61: 1805-1809.
    • (2001) Cancer Res , vol.61 , pp. 1805-1809
    • Kuriyama, N.1    Kuriyama, H.2    Julin, C.M.3    Lamborn, K.R.4    Israel, M.A.5


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