Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 298, Issue 2, 2010, Pages

  Subramanian, Veedamali S ^a,c   Marchant, Jonathan S ^b   Said, Hamid M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Ascorbic acid; Trafficking; Uptake

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; HYBRID PROTEIN; NOCODAZOLE; SODIUM DEPENDENT VITAMIN C TRANSPORTER 2; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; LIVER CELL; MICROFILAMENT; MICROTUBULE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS; TERMINAL SEQUENCE; VIDEORECORDING;

ASCORBIC ACID; BACTERIAL PROTEINS; CARBON RADIOISOTOPES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MEMBRANE; GENE EXPRESSION; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MOLECULAR MOTOR PROTEINS; MUTAGENESIS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SYMPORTERS; TRANSFECTION;

EID: 76749113011     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00435.2009     Document Type: Article

References (40)

1. Apodaca G. Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton. Traffic 2: 149-159, 2001.
2. Artigas P, Al'aref SJ, Hobart EA, Diaz LF, Sakaguchi M, Straw S, Andersen OS. 2,3-Butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties. Mol Pharmacol 70: 2015-2026, 2006.
3. Ashokkumar B, Nabokina SM, Ma TY, Said HM. Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. Am J Physiol Gastrointest Liver Physiol 297: G480-G487, 2009.
4. 2+ signalling competency. J Physiol 586: 2873-2888, 2008.
5. Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM. Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochem Biophys Res Commun 334: 150-156, 2005.
6. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 69: 1086-1107, 1999.
7. Chen EY, Bartlett MC, Loo TW, Clarke DM. The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 279: 39620-39627, 2004.
8. D'Souza VM, Bareford LM, Ray A, Swaan PW. Cytoskeletal scaffolds regulate riboflavin endocytosis and recycling in placental trophoblasts. J Nutr Biochem 17: 821-829, 2006.
9. Dranoff JA, McClure M, Burgstahler AD, Denson LA, Crawford AR, Crawford JM, Karpen SJ, Nathanson MH. Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane. Hepatology 30: 223-229, 1999.
10. Gu HH, Wu X, Giros B, Caron MG, Caplan MJ, Rudnick G. The NH(2) terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Mol Biol Cell 12: 3797-3807, 2001.
11. Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98: 2485-2490, 2003.
12. Herrema H, Czajkowska D, Theard D, van der Wouden JM, Kalicharan D, Zolghadr B, Hoekstra D, van Ijzendoorn SC. Rho kinase, myosin-II, and p42/44 MAPK control extracellular matrix-mediated apical bile canalicular lumen morphogenesis in HepG2 cells. Mol Biol Cell 17: 3291-3303, 2006.
13. 3 cotransporter NBC1 that mediates basolateral targeting. Am J Physiol Renal Physiol 292: F1245-F1255, 2007.
14. Li Y, Schellhorn HE. New developments and novel therapeutic perspectives for vitamin C. J Nutr 137: 2171-2184, 2007.
15. Liang WJ, Johnson D, Jarvis SM. Vitamin C transport systems of mammalian cells. Mol Membr Biol 18: 87-95, 2001.
16. Marchant JS, Subramanian VS, Parker I, Said HM. Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. J Biol Chem 277: 33325-33333, 2002.
17. Martinez-Maza R, Poyatos I, Lopez-Corcuera B, Nu E, Gimenez C, Zafra F, Aragon C. The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2. J Biol Chem 276: 2168-2173, 2001.
18. Maulen NP, Henriquez EA, Kempe S, Carcamo JG, Schmid-Kotsas A, Bachem M, Grunert A, Bustamante ME, Nualart F, Vera JC. Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells. J Biol Chem 278: 9035-9041, 2003.
19. Muth TR, Ahn J, Caplan MJ. Identification of sorting determinants in the C-terminal cytoplasmic tails of the gamma-aminobutyric acid transporters GAT-2 and GAT-3. J Biol Chem 273: 25616-25627, 1998.
20. Packer L, Fuchs J. Vitamin C in Health and Disease. New York: Dekker, 1997.
21. Rai T, Sasaki S, Uchida S. Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal. Am J Physiol Cell Physiol 290: C298-C304, 2006.
22. Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD. Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. Biochem Biophys Res Commun 262: 762-768, 1999.
23. Reidling JC, Subramanian VS, Dahhan T, Sadat M, Said HM. Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol 295: G1217-G1227, 2008.
24. Rivas CI, Zuniga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. Vitamin C transporters. J Physiol Biochem 64: 357-375, 2008.
25. Roelofsen H, Wolters H, Van Luyn MJ, Miura N, Kuipers F, Vonk RJ. Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion. Gastroenterology 119: 782-793, 2000.
26. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 34: 347-355, 2008.
27. Simon JA, Hudes ES. Serum ascorbic acid and gallbladder disease prevalence among US adults: the Third National Health and Nutrition Examination Survey (NHANES III). Arch Intern Med 160: 931-936, 2000.
28. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nat Med 8: 514-517, 2002.
29. Subramanian VS, Marchant JS, Boulware MJ, Ma TY, Said HM. Membrane targeting and intracellular trafficking of the human sodiumdependent multivitamin transporter in polarized epithelial cells. Am J Physiol Cell Physiol 296: C663-C671, 2009.
30. Subramanian VS, Marchant JS, Boulware MJ, Said HM. A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. J Biol Chem 279: 27719-27728, 2004.
31. Subramanian VS, Marchant JS, Parker I, Said HM. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem 278: 3976-3984, 2003.
32. +-dependent vitamin C transporter functionality. Biochem Biophys Res Commun 374: 123-127, 2008.
33. Subramanian VS, Marchant JS, Said HM. Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J Biol Chem 281: 5233-5245, 2006.
34. Sun AQ, Salkar R, Sachchidanand, Xu S, Zeng L, Zhou MM, Suchy FJ. A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem 278: 4000-4009, 2003.
35. Takanaga H, Mackenzie B, Hediger MA. Sodium-dependent ascorbic acid transporter family SLC23. Pflügers Arch 447: 677-682, 2004.
36. Varma S, Sobey K, Campbell C, Kuo SM. Hierarchal contribution of Nand C-terminal sequences to the differential localization of homologous sodium-dependent vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochemistry 48: 2969-2980, 2009.
37. Velho AM, Jarvis SM. Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting. Exp Cell Res 315: 2312-2321, 2009.
38. Wang H, Dutta B, Huang W, Devoe LD, Leibach FH, Ganapathy V, Prasad PD. Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a nonfunctional splice variant. Biochim Biophys Acta 1461: 1-9, 1999.
39. Wojtal KA, de Vries E, Hoekstra D, van Ijzendoorn SC. Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide. Mol Biol Cell 17: 3638-3650, 2006.
40. Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol Pharmacol 67: 868-876, 2005.