The NH2-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells

Molecular Biology of the Cell

Volumn 12, Issue 12, 2001, Pages 3797-3807

  Gu, H H ^a   Wu, X ^a   Giros, B ^a   Caron, M G ^a   Caplan, M J ^a   Rudnick, G ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; LEUCINE; NORADRENALIN TRANSPORTER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; EPITHELIUM CELL; GENE CONSTRUCT; GENE MUTATION; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL PROCESSING;

ANIMALIA;

EID: 0035661621     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.12.3797     Document Type: Article

References (77)

1. Polarized expression of GABA transporters in Madin-Darby canine kidney cells and cultured hippocampal neurons
2. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
3. Neurotransmitter transporters-recent progress
4. Acute regulation of norepinephrine transport. II. Pkc-modulated surface expression of human norepinephrine transporter proteins
5. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes
6. The serotonin hypothesis of obsessive compulsive disorder-implications of pharmacologic challenge studies
7. Cloning and expression of a functional serotonin transporter from rat brain
8. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins
9. Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system-cloning of 2 novel high affinity GABA transporters from rat brain
10. Neurotransmitter transporters: Molecular biology, function, and regulation
11. An overview of paroxetine
12. Chimeric dopamine norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
13. Cocaine inhibits GABA release in the VTA through endogenous 5-HT
14. The sorting of membrane and secretory proteins in polarized epithelial cells
15. [3H]nisoxetine binding sites in the cat brain: An autoradiographic study
16. Determination of external loop topology in the serotonin transporter by site-directed chemical labeling
17. Mechanisms of neuronal polarity
18. The dopamine transporter-immunochemical characterization and localization in brain
19. 3H]-paroxetine-labeled serotonin uptake sites in rat brain
20. Membrane traffic in polarized neurons in culture
21. Polarized sorting of glypiated proteins in hippocampal neurons
22. Polarized sorting of viral glycoproteins to axons and dendrites of hippocampal neurons in culture
23. A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization
24. Molecular characterization of the dopamine transporter
25. Cloning and functional characterization of a cocaine-sensitive dopamine transporter
26. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters
27. Synthesis and sorting of ion pumps in polarized cells
28. An ion-transporting ATPase encodes multiple apical localization signals
29. Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments
30. Cloned catecholamine transporters expressed in polarized epithelial cells: Sorting, drug sensitivity, and ion-coupling stoichiometry
31. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells
32. Stable expression of biogenic amine transporters reveals differences in ion dependence and inhibitor sensitivity
33. Cloning and expression of a rat brain GABA transporter
34. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells
35. Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail
36. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra
37. Cloning of a serotonin transporter affected by antidepressants
38. Cloning and expression of a cocaine-sensitive rat dopamine transporter
39. Preclinical pharmacology of sertraline-a potent and specific inhibitor of serotonin reuptake
40. 125I]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain
41. HSV1 vectors to study protein targeting in neurones: Are glycosyl-phosphatidylinositol anchors polarized targeting signals in neurones?
42. Molecular regulation of Glut-4 targeting in 3t3-L1 adipocytes
43. Mechanisms of cell polarity-sorting and transport in epithelial cells
44. Membrane trafficking regulates the activity of the human dopamine transporter
45. Identification of sorting determinants in the C-terminal cytoplasmic tails of the gamma-aminobutyric acid transporters Gat-2 and Gat-3
46. Porters and neurotransmitter transporters
47. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons-potential sites for somatodendritic storage and release of dopamine
48. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
49. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei
50. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
51. Sorting of two polytopic proteins, the gamma-aminobutyric acid and betaine transporters, in polarized epithelial cells
52. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens
53. Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture
54. The axonal GABA transporter is sorted to the apical membrane of polarized epithelial cells
55. Polarized distribution of glycine transporter isoforms in epithelial and neuronal cells
56. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter
57. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies
58. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
59. Active transport of dopamine in human placental brush-border membrane vesicles
60. Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast
61. 3H]GBR 12935: Binding characteristics
62. Cocaine receptors on dopamine transporters are related to self-administration of cocaine
63. Morphogenesis of the polarized epithelial cell phenotype
64. LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia
65. 1 epithelial cells
66. Mechanisms of biogenic amine neurotransmitter transporters
67. From synapse to vesicle: The reuptake and storage of biogenic amine neurotransmitters
68. Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4
69. Immunolocalization of the cocaine and antidepressant-sensitive I-norepinephrine transporter
70. A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells
71. Anti-hyperactivity medication: Methylphenidate and amphetamine
72. Equivalent effects of stimulant treatment for attention-deficit hyperactivity disorder during childhood and adolescence
73. 3H]nisoxetine: A radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding
74. Signal-dependent membrane protein trafficking in the endocytic pathway
75. Neurotransmitter transporters (plus) - A promising new gene family
76. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain
77. --dependent betaine transporter that is regulated by hypertonicity