Cutting edge: Notch signaling induces a distinct cytokine profile in dendritic cells that supports T cell-mediated regulation and IL-2-dependent IL-17 production

Journal of Immunology

Volumn 181, Issue 12, 2008, Pages 8189-8193

  Bugeon, Laurence ^a   Gardner, Leanne M ^a   Rose, Anna ^a   Gentle, Madeleine ^a   Dallman, Margaret J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23P19; INTERLEUKIN 5; INTERLEUKIN 6; JAGGED1; LIPOPOLYSACCHARIDE; MESSENGER RNA; NOTCH RECEPTOR; PROTEIN DIL1; PROTEIN DIL4; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CYTOKINE; DLK1 PROTEIN, MOUSE; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; GENETICS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RAT;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-17; INTERLEUKIN-2; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RECEPTORS, NOTCH; T-LYMPHOCYTES, REGULATORY;

EID: 58849108569     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.12.8189     Document Type: Article

References (23)

1. Garbe, A. I., and H. von Boehmer. 2007. TCR and Notch synergize in αβversus γδ lineage choice. Transplant Immunol. 28: 124-131.
2. Laky, K., and B. J. Fowlkes. 2008. Notch signaling in CD4 and CD8 T cell development. Curr. Opin. Immunol. 20: 197-202.
3. Dallman, M. J., E. Smith, R. A. Benson, and J. R. Lamb. 2005. Notch: control of lymphocyte differentiation in the periphery. Curr. Opin. Immunol. 17: 259-266.
4. Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigenpresenting cells. Cell 117: 515-526. (Pubitemid 38610236)
5. Palaga, T., C. Buranaruk, S. Rengpipat, A. H. Fauq, T. E. Golde, S. H. Kaufmann, and B. A. Osborne. 2008. Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur. J. Immunol. 38: 174-183.
6. Weijzen, S., M. P. Velders, A. G. Elmishad, P. E. Bacon, J. R. Panella, B. J. Nickoloff, L. Miele, and W. M. Kast. 2002. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells. J. Immunol. 169: 4273-4278. (Pubitemid 35178199)
7. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693-1702.
8. Granucci, F., C. Vizzardelli, N. Pavelka, S. Feau, M. Persico, E. Virzi, M. Rescigno, G. Moro, and P. Ricciardi-Castagnoli. 2001. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 9: 882-888. (Pubitemid 34906455)
9. Rutz, S., B. Mordmüller, S. Sakano, and A. Scheffold. 2005. Notch ligands Deltalike1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur. J. Immunol. 35: 2443-2451. (Pubitemid 41179765)
10. Lehar, S. M., J. Dooley, A. G. Farr, and M. J. Bevan. 2004. Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood 105: 1440-1447.
11. Feau, S., V. Facchinetti, F. Granucci, S. Citterio, D. Jarrossay, S. Seresini, M. P. Protti, A. Lanzavecchia, and P. Ricciardi-Castagnoli. 2005. Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice. Blood 105: 697-702. (Pubitemid 40070755)
12. Malek, T. R., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2: 167-178.
13. Almeida, A. R., N. Legrand, M. Papiernik, and A. A. Freitas. 2002. Homeostasis of peripheral CD4+ T cells: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169: 4850-4860.
14. pos regulatory T-cells differentiate into IL-17 producing cells. Blood 112: 2340-2352.
15. Stark, M. A., Y. Huo, T. L. Burcin, M. A. Morris, T. S. Olson, and K. Ley. 2005. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22: 285-294.
16. Lockhart, E., A. M. Green, and J. L. Flynn. 2006. IL-17 production is dominated by γδT cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J. Immunol. 177: 4662-4669. (Pubitemid 44469799)
17. Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381. (Pubitemid 46413906)
18. Wilson, N. S., L. J. Young, F. Kupresanin, S. H. Naik, D. Vremec, W. R. Heath, S. Akira, K. Shortman, J. Boyle, E. Maraskovsky, et al. 2008. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling. Immunol. Cell Biol. 86: 200-205.
19. Santagata, S., F. Demichelis, A. Riva, S. Varambally, M. D. Hofer, J. L. Kutok, R. Kim, J. Tang, J. E. Montie, A. M. Chinnaiyan, et al. 2004. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 64: 6854-6857. (Pubitemid 39330990)
20. Reedijk, M., S. Odorcic, L. Chang, H. Zhang, N. Miller, D. R. McCready, G. Lockwood, and S. E. Egan. 2005. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 65: 8530-8537. (Pubitemid 41330622)
21. John, G. R., S. L. Shankar, B. Shafit-Zagardo, A. Massimi, S. C. Lee, C. S. Raine, and C. F. Brosnan. 2002. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat. Med. 8: 1115-1121.
22. Elyaman, W., E. M. Bradshaw, Y. Wang, M. Oukka, P. Kivisäkk, S. Chiba, H. Yagita, and S. J. Khouri. 2007. Jagged1 and Delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179: 5990-5998.
23. Palacios, R., J. Goni, I. Martinez-Forero, J. Iranzo, J. Sepulcre, I. Melero, and P. Villoslada. 2007. A network analysis of the human T-cell activation gene network identifies JAGGED1 as a therapeutic target for autoimmune diseases. PLoS ONE 2: e1222. (Pubitemid 351673969)