메뉴 건너뛰기




Volumn 48, Issue 2, 2010, Pages 120-128

The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil

Author keywords

Gabapentin; Gabapentin enacarbil; GSK1838262; Pharmacokinetics; XP13512

Indexed keywords

GABAPENTIN; GABAPENTIN ENACARBIL;

EID: 76749099240     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP48120     Document Type: Article
Times cited : (18)

References (24)
  • 1
    • 0028041242 scopus 로고
    • Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: A double-blind, placebo-controlled study. The International Gabapentin Study Group
    • Anhut H, Ashman P, Feuerstein TJ, Sauermann W, Saunders M, Schmidt B. Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: a double-blind, placebo-controlled study. The International Gabapentin Study Group. Epilepsia. 1994; 35: 795-801.
    • (1994) Epilepsia , vol.35 , pp. 795-801
    • Anhut, H.1    Ashman, P.2    Feuerstein, T.J.3    Sauermann, W.4    Saunders, M.5    Schmidt, B.6
  • 2
    • 0032800766 scopus 로고    scopus 로고
    • Gabapentin as add-on therapy in children with refractory partial seizures: A 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group
    • Appleton R, Fichtner K, LaMoreaux L, Alexander J, Halsall G, Murray G, Garofalo E. Gabapentin as add-on therapy in children with refractory partial seizures: a 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group. Epilepsia. 1999; 40: 1147-1154.
    • (1999) Epilepsia , vol.40 , pp. 1147-1154
    • Appleton, R.1    Fichtner, K.2    LaMoreaux, L.3    Alexander, J.4    Halsall, G.5    Murray, G.6    Garofalo, E.7
  • 3
    • 4644251930 scopus 로고    scopus 로고
    • Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, Shirsat P, Torneros A, Yao F, Zou J, Barrett RW, Gallop MA. XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther. 2004; 311: 324-333.
    • Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, Shirsat P, Torneros A, Yao F, Zou J, Barrett RW, Gallop MA. XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther. 2004; 311: 324-333.
  • 4
    • 4644328982 scopus 로고    scopus 로고
    • Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, Koller K, Liu X, Mann A, Panuwat M, Raillard SP, Upadhyay S, Wu QQ, Xiang JN, Yan H, Zerangue N, Zhou CX, Barrett RW, Gallop MA. XP13512 [(+/-)-1-([(alpha- isobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters. J Pharmacol Exp Ther. 2004; 311: 315-323.
    • Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, Koller K, Liu X, Mann A, Panuwat M, Raillard SP, Upadhyay S, Wu QQ, Xiang JN, Yan H, Zerangue N, Zhou CX, Barrett RW, Gallop MA. XP13512 [(+/-)-1-([(alpha- isobutanoyloxyethoxy) carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters. J Pharmacol Exp Ther. 2004; 311: 315-323.
  • 5
    • 57449097189 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin
    • Cundy KC, Sastry S, Luo W, Zou J, Moors TL, Canafax DM. Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin. J Clin Pharmacol. 2008; 48: 1378-1388.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1378-1388
    • Cundy, K.C.1    Sastry, S.2    Luo, W.3    Zou, J.4    Moors, T.L.5    Canafax, D.M.6
  • 6
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • Dresser GK, Bailey DG, Leake BF, Schwartz UI, Dawson PA, Freeman DJ, Kin RB. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther. 2002; 71: 11-20.
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3    Schwartz, U.I.4    Dawson, P.A.5    Freeman, D.J.6    Kin, R.B.7
  • 9
    • 0027454448 scopus 로고
    • Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy
    • Goa KL, Sorkin EM. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993; 46: 409-427.
    • (1993) Drugs , vol.46 , pp. 409-427
    • Goa, K.L.1    Sorkin, E.M.2
  • 10
    • 33646100289 scopus 로고    scopus 로고
    • Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoAreductase inhibitor, in rats and healthy human subjects
    • Koitabashi Y, Kumai T, Matsumoto N, Watanabe M, Sekine S, Yanagida Y, Kobayashi S. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoAreductase inhibitor, in rats and healthy human subjects. Life Science. 2006; 78: 2852-2859.
    • (2006) Life Science , vol.78 , pp. 2852-2859
    • Koitabashi, Y.1    Kumai, T.2    Matsumoto, N.3    Watanabe, M.4    Sekine, S.5    Yanagida, Y.6    Kobayashi, S.7
  • 12
    • 61549121079 scopus 로고    scopus 로고
    • XP052 Study Group. Randomized, double-blind, placebo-controlled study of XP-13512/GSK1838262 in patients with RLS
    • Kushida CA, Becker PM, Ellenbogen AL, Canafax DM, Barrett RW; XP052 Study Group. Randomized, double-blind, placebo-controlled study of XP-13512/GSK1838262 in patients with RLS. Neurology. 2009; 72: 439-446.
    • (2009) Neurology , vol.72 , pp. 439-446
    • Kushida, C.A.1    Becker, P.M.2    Ellenbogen, A.L.3    Canafax, D.M.4    Barrett, R.W.5
  • 13
    • 85036795391 scopus 로고    scopus 로고
    • Lal R, Sukbuntherng J, Luo W, Jacob Huff F, Blumenthal R, Cundy KC. Adouble-blind, placebo-controlled, dose escalation study of the pharmacokinetics of oral XP13512 in healthy adults. Presented at American Association of Pharmaceutical Scientists 2008, Baltimore, US. Sleep. 2008; 31 (Suppl): 267 (abstract 0815).
    • Lal R, Sukbuntherng J, Luo W, Jacob Huff F, Blumenthal R, Cundy KC. Adouble-blind, placebo-controlled, dose escalation study of the pharmacokinetics of oral XP13512 in healthy adults. Presented at American Association of Pharmaceutical Scientists 2008, Baltimore, US. Sleep. 2008; 31 (Suppl): 267 (abstract 0815).
  • 14
    • 1542346411 scopus 로고    scopus 로고
    • Orange juice substantially reduces the bioavailability of the β-adrenergic-blocking agent celiprolol
    • Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the β-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther. 2004; 75: 184-190.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 184-190
    • Lilja, J.J.1    Juntti-Patinen, L.2    Neuvonen, P.J.3
  • 15
    • 27644463532 scopus 로고    scopus 로고
    • Effects of orange juice on the pharmacokinetics of atenolol
    • Lilja JJ, Raaska K, Neuvonen PJ. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol. 2005; 61: 337-340.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 337-340
    • Lilja, J.J.1    Raaska, K.2    Neuvonen, P.J.3
  • 16
    • 0029057902 scopus 로고
    • Gabapentin
    • McLean MJ. Gabapentin. Epilepsia. 1995; 36 (Suppl): 73-86.
    • (1995) Epilepsia , vol.36 , Issue.SUPPL. , pp. 73-86
    • MJ, M.1
  • 17
    • 0032819783 scopus 로고    scopus 로고
    • Gabapentin in the management of convulsive disorders
    • McLean MJ. Gabapentin in the management of convulsive disorders. Epilepsia. 1999; 40(Suppl): 39-50.
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. , pp. 39-50
    • MJ, M.1
  • 18
    • 0034750718 scopus 로고    scopus 로고
    • Postherpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia: A randomised, double blind, placebo controlled study
    • Rice AS, Maton S; Postherpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain. 2001; 94: 215-224.
    • (2001) Pain , vol.94 , pp. 215-224
    • Rice, A.S.1    Maton, S.2
  • 19
    • 0032477305 scopus 로고    scopus 로고
    • Gabapentin for the treatment of postherpetic neuralgia: A randomized, controlled trial
    • Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized, controlled trial. JAMA. 1998; 280: 1837-1842.
    • (1998) JAMA , vol.280 , pp. 1837-1842
    • Rowbotham, M.1    Harden, N.2    Stacey, B.3    Bernstein, P.4    Magnus-Miller, L.5
  • 20
    • 0032883045 scopus 로고    scopus 로고
    • Effects of food on clinical pharmacokinetics
    • Singh BN. Effects of food on clinical pharmacokinetics. Clin Pharmacokinet. 1999; 37: 213-255.
    • (1999) Clin Pharmacokinet , vol.37 , pp. 213-255
    • BN, S.1
  • 21
    • 0031028878 scopus 로고    scopus 로고
    • Colonic absorption of antiepileptic agents
    • Stevenson CM, Kim J, Fleisher D. Colonic absorption of antiepileptic agents. Epilepsia. 1997; 38: 63-67.
    • (1997) Epilepsia , vol.38 , pp. 63-67
    • Stevenson, C.M.1    Kim, J.2    Fleisher, D.3
  • 22
    • 0027402753 scopus 로고
    • A saturable transport mechanismin the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
    • Stewart BH, Kugler AR, Thompson PR, Bockbrader HN. A saturable transport mechanismin the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm Res. 1993; 10: 276-281.
    • (1993) Pharm Res , vol.10 , pp. 276-281
    • Stewart, B.H.1    Kugler, A.R.2    Thompson, P.R.3    Bockbrader, H.N.4
  • 23
    • 0027374164 scopus 로고
    • Gabapentin as add-on therapy in refractory partial epilepsy: A double-blind, placebo-controlled, parallel-group study
    • The US Gabapentin Study Group No 5
    • The US Gabapentin Study Group No 5. Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallel-group study. Neurology. 1993; 43: 2292-2298.
    • (1993) Neurology , vol.43 , pp. 2292-2298
  • 24
    • 0025343921 scopus 로고
    • Gabapentin in partial epilepsy
    • UK Gabapentin Study Group
    • UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet. 1990; 335: 1114-1117.
    • (1990) Lancet , vol.335 , pp. 1114-1117


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.