PEG-PLA microparticles for encapsulation and delivery of Tat-EGFP to retinal cells

Biomaterials

Volumn 31, Issue 12, 2010, Pages 3414-3421

  Rafat, Mehrdad ^a,b   Cléroux, Carolyne A ^a,b   Fong, Wai Gin ^a   Baker, Adam N ^a   Leonard, Brian C ^a   O'Connor, Michael D ^a   Tsilfidis, Catherine ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Biodegradation; Electron microscopy; Gene therapy; Microencapsulation; Polylactic acid; Retina

Indexed keywords

CELLULAR TOXICITIES; CONTROLLED DELIVERY; ENHANCED GREEN FLUORESCENT PROTEIN; IN-CELL; IN-VITRO; IN-VIVO; MICRO-PARTICLES; MICROENCAPSULATION; MICROPARTICLE SYSTEMS; OPTIMUM FORMULATION; PARTICLE MORPHOLOGIES; PHOTORECEPTOR LAYERS; POLY LACTIC ACID; POLYMER CONCENTRATIONS; PROTEIN RELEASE; RAPID RELEASE; RETINAL CELLS; SEM; SUSTAINED RELEASE; TRANSACTIVATORS;

ACIDS; BIOCOMPATIBILITY; BIODEGRADATION; CELL CULTURE; DEGRADATION; ENCAPSULATION; GENE THERAPY; GENETIC ENGINEERING; MICROBIOLOGY; OPHTHALMOLOGY; PACKAGING; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SCANNING ELECTRON MICROSCOPY; TOXICITY; TRANSCRIPTION;

PROTEINS;

MACROGOL; POLYLACTIC ACID; TRANSACTIVATOR OF TRANSCRIPTION ENHANCED GREEN FLUORESCENT FUSION PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL CULTURE; CONTROLLED STUDY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; FEMALE; FLUOROMETRY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; RETINA CELL; SCANNING ELECTRON MICROSCOPY; TOXICITY TESTING; ULTRASOUND;

ANIMALS; CELLS, CULTURED; DRUG CARRIERS; FLUOROMETRY; GENE PRODUCTS, TAT; GREEN FLUORESCENT PROTEINS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RETINA;

RATTUS;

EID: 76749091372     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.01.031     Document Type: Article

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