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Volumn 51, Issue 1, 2010, Pages 60-67

Effects of raloxifene on brachial arterial endothelial function, carotid wall thickness, and arterial stiffness in osteoporotic postmenopausal women

Author keywords

Arterial stiffness; Carotid wall thickness; Endothelial function; Postmenopausal women; Raloxifene

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLESTEROL; DIURETIC AGENT; ESTRADIOL; FOLLITROPIN; GLUCOSE; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RALOXIFENE; TRIACYLGLYCEROL;

EID: 76749086943     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.51.60     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ERalpha and ERbeta at API sites
    • Paech K, Webb P, Kuiper GG, et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at API sites. Science 1997; 277: 1508-10.
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.3
  • 3
    • 0033575083 scopus 로고    scopus 로고
    • The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    • Cummings SR, Eckert S, Krueger KA, et al. The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. JAMA 1999; 281: 2189-97.
    • (1999) JAMA , vol.281 , pp. 2189-2197
    • Cummings, S.R.1    Eckert, S.2    Krueger, K.A.3
  • 4
    • 0037138787 scopus 로고    scopus 로고
    • Raloxifene and cardiovascular events in osteoporotic postmenopausal women: Four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial
    • Barrett-Connor E, Grady D, Sashegyi A, et al. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial. JAMA 2002; 287: 847-57.
    • (2002) JAMA , vol.287 , pp. 847-857
    • Barrett-Connor, E.1    Grady, D.2    Sashegyi, A.3
  • 5
    • 61849168916 scopus 로고    scopus 로고
    • Effects of the selective estrogen receptor modulator raloxifene on coronary outcomes in the Raloxifene Use for The Heart trial: Results of subgroup analyses by age and other factors
    • Collins P, Mosca L, Geiger MJ, et al. Effects of the selective estrogen receptor modulator raloxifene on coronary outcomes in the Raloxifene Use for The Heart trial: results of subgroup analyses by age and other factors. Circulation 2009; 119: 922-30.
    • (2009) Circulation , vol.119 , pp. 922-930
    • Collins, P.1    Mosca, L.2    Geiger, M.J.3
  • 6
    • 0037153047 scopus 로고    scopus 로고
    • Endothelial function. From vascular biology to clinical applications
    • Review
    • Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002; 90: 40L-8. (Review)
    • (2002) Am J Cardiol , vol.90
    • Behrendt, D.1    Ganz, P.2
  • 8
    • 0036464193 scopus 로고    scopus 로고
    • Intima-media thickness: A new tool for diagnosis and treatment of cardiovascular risk
    • Review
    • Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002; 20: 159-69. (Review)
    • (2002) J Hypertens , vol.20 , pp. 159-169
    • Simon, A.1    Gariepy, J.2    Chironi, G.3    Megnien, J.L.4    Levenson, J.5
  • 9
  • 10
    • 0035572888 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma no concentrations, endothelin-1 levels, and endothelium-dependent vasodilatation in postmenopausal women
    • Saitta A, Altavilla D, Cucinotta D, et al. Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma no concentrations, endothelin-1 levels, and endothelium-dependent vasodilatation in postmenopausal women. Arterioscler Thromb Vasc Biol 2001; 21: 1512-9.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1512-1519
    • Saitta, A.1    Altavilla, D.2    Cucinotta, D.3
  • 11
    • 34948852292 scopus 로고    scopus 로고
    • Raloxifene slows down the progression of intima-media thickness in postmenopausal women
    • Colacurci N, Fornaro F, Cobellis L, et al. Raloxifene slows down the progression of intima-media thickness in postmenopausal women. Menopause 2007; 14: 879-84.
    • (2007) Menopause , vol.14 , pp. 879-884
    • Colacurci, N.1    Fornaro, F.2    Cobellis, L.3
  • 12
    • 9344257290 scopus 로고    scopus 로고
    • Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women
    • da Costa LS, de Oliveira MA, Rubim VS, et al. Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women. Am J Cardiol 2004; 94: 1453-6.
    • (2004) Am J Cardiol , vol.94 , pp. 1453-1456
    • da Costa, L.S.1    de Oliveira, M.A.2    Rubim, V.S.3
  • 13
    • 28844490186 scopus 로고    scopus 로고
    • Effect of raloxifene on aortic elasticity in healthy postmenopausal women
    • Tritos NA, Goepfert L, Kissinger KV, et al. Effect of raloxifene on aortic elasticity in healthy postmenopausal women. Am Heart J 2005; 150: 1212.
    • (2005) Am Heart J , vol.150 , pp. 1212
    • Tritos, N.A.1    Goepfert, L.2    Kissinger, K.V.3
  • 14
    • 0033105456 scopus 로고    scopus 로고
    • The association between low bone mass at the menopause and cardiovascular mortality
    • von der Recke P, Hansen MA, Hassager C. The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 1999;106:273-8.
    • (1999) Am J Med , vol.106 , pp. 273-278
    • von der Recke, P.1    Hansen, M.A.2    Hassager, C.3
  • 15
    • 0031558504 scopus 로고    scopus 로고
    • Cardiovascular disease in women: A statement for healthcare professionals from the American Heart Association. Writing Group
    • Mosca L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E. Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Writing Group. Circulation 1997; 96: 2468-82.
    • (1997) Circulation , vol.96 , pp. 2468-2482
    • Mosca, L.1    Manson, J.E.2    Sutherland, S.E.3    Langer, R.D.4    Manolio, T.5    Barrett-Connor, E.6
  • 16
    • 34948841571 scopus 로고    scopus 로고
    • Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women
    • Sumino H, Ichikawa S, Kasama S, et al. Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women. Circ J 2007; 71: 1555-9.
    • (2007) Circ J , vol.71 , pp. 1555-1559
    • Sumino, H.1    Ichikawa, S.2    Kasama, S.3
  • 17
    • 5644235491 scopus 로고    scopus 로고
    • Forearm endothelial function and bone mineral loss in postmenopausal women
    • Sanada M, Taguchi A, Higashi Y, et al. Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis 2004; 176: 387-92.
    • (2004) Atherosclerosis , vol.176 , pp. 387-392
    • Sanada, M.1    Taguchi, A.2    Higashi, Y.3
  • 18
    • 48349113832 scopus 로고    scopus 로고
    • Relationship between carotid atherosclerosis and lumbar spine bone mineral density in postmenopausal women
    • Sumino H, Ichikawa S, Kasama S, et al. Relationship between carotid atherosclerosis and lumbar spine bone mineral density in postmenopausal women. Hypertens Res 2008; 31: 1191-7.
    • (2008) Hypertens Res , vol.31 , pp. 1191-1197
    • Sumino, H.1    Ichikawa, S.2    Kasama, S.3
  • 19
    • 0030865762 scopus 로고    scopus 로고
    • Bone changes and carotid atherosclerosis in postmenopausal women
    • Uyama O, Yoshimoto Y, Yamamoto Y, Kawai A. Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 1997; 28: 1730-2.
    • (1997) Stroke , vol.28 , pp. 1730-1732
    • Uyama, O.1    Yoshimoto, Y.2    Yamamoto, Y.3    Kawai, A.4
  • 20
    • 33748787417 scopus 로고    scopus 로고
    • Elevated arterial stiffness in postmenopausal women with osteoporosis
    • Sumino H, Ichikawa S, Kasama S, et al. Elevated arterial stiffness in postmenopausal women with osteoporosis. Maturitas 2006; 55: 212-8.
    • (2006) Maturitas , vol.55 , pp. 212-218
    • Sumino, H.1    Ichikawa, S.2    Kasama, S.3
  • 21
    • 0038305708 scopus 로고    scopus 로고
    • Increased pulse wave velocity associated with reduced calcaneal quantitative osteosono index: Possible relationship between atherosclerosis and osteopenia
    • Hirose K, Tomiyama H, Okazaki R, et al. Increased pulse wave velocity associated with reduced calcaneal quantitative osteosono index: possible relationship between atherosclerosis and osteopenia. J Clin Endocrinol Metab 2003; 88: 2573-8.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2573-2578
    • Hirose, K.1    Tomiyama, H.2    Okazaki, R.3
  • 23
    • 0038460302 scopus 로고    scopus 로고
    • Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
    • The Seventh Report of the Joint National Committee on Prevention
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560-72.
    • (2003) JAMA , vol.289 , pp. 2560-2572
  • 24
    • 0003175257 scopus 로고    scopus 로고
    • Investigating committee of guidelines for diagnosis and treatment of hyperlipidemias
    • Investigating committee of guidelines for diagnosis and treatment of hyperlipidemias. J Jpn Atheroscler Soc 1997; 25: 1-34.
    • (1997) J Jpn Atheroscler Soc , vol.25 , pp. 1-34
  • 25
    • 20744446634 scopus 로고    scopus 로고
    • Effect of transdermal hormone replacement therapy on the monocyte chemoattractant protein-1 concentrations and other vascular inflammatory markers and on endothelial function in postmenopausal women
    • Sumino H, Ichikawa S, Ohyama Y, et al. Effect of transdermal hormone replacement therapy on the monocyte chemoattractant protein-1 concentrations and other vascular inflammatory markers and on endothelial function in postmenopausal women. Am J Cardiol 2005; 96: 148-53.
    • (2005) Am J Cardiol , vol.96 , pp. 148-153
    • Sumino, H.1    Ichikawa, S.2    Ohyama, Y.3
  • 26
    • 20044370806 scopus 로고    scopus 로고
    • Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure-possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine
    • Ohike Y, Kozaki K, Iijima K, et al. Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure-possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 2005; 69: 221-6.
    • (2005) Circ J , vol.69 , pp. 221-226
    • Ohike, Y.1    Kozaki, K.2    Iijima, K.3
  • 27
    • 25844518448 scopus 로고    scopus 로고
    • Effect of transdermal hormone replacement therapy on carotid artery wall thickness and levels of vascular inflammatory markers in postmenopausal women
    • Sumino H, Ichikawa S, Kasama S, et al. Effect of transdermal hormone replacement therapy on carotid artery wall thickness and levels of vascular inflammatory markers in postmenopausal women. Hypertens Res 2005; 28: 579-84.
    • (2005) Hypertens Res , vol.28 , pp. 579-584
    • Sumino, H.1    Ichikawa, S.2    Kasama, S.3
  • 28
    • 34047225993 scopus 로고    scopus 로고
    • Masked nocturnal hypertension and target organ damage in hypertensives with well-controlled self-measured home blood pressure
    • Hoshide S, Ishikawa J, Eguchi K, Ojima T, Shimada K, Kario K. Masked nocturnal hypertension and target organ damage in hypertensives with well-controlled self-measured home blood pressure. Hypertens Res 2007; 30: 143-9.
    • (2007) Hypertens Res , vol.30 , pp. 143-149
    • Hoshide, S.1    Ishikawa, J.2    Eguchi, K.3    Ojima, T.4    Shimada, K.5    Kario, K.6
  • 29
    • 0035991078 scopus 로고    scopus 로고
    • Validity, reproducibility, and clinical significance of noninvasive brachialankle pulse wave velocity measurement
    • Yamashina A, Tomiyama H, Takeda K, et al. Validity, reproducibility, and clinical significance of noninvasive brachialankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359-64.
    • (2002) Hypertens Res , vol.25 , pp. 359-364
    • Yamashina, A.1    Tomiyama, H.2    Takeda, K.3
  • 30
    • 33749070883 scopus 로고    scopus 로고
    • Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women
    • Sumino H, Ichikawa S, Kasama S, et al. Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women. Atherosclerosis 2006; 189: 436-42.
    • (2006) Atherosclerosis , vol.189 , pp. 436-442
    • Sumino, H.1    Ichikawa, S.2    Kasama, S.3
  • 31
    • 25844513804 scopus 로고    scopus 로고
    • High blood pressure, bone-mineral loss and insulin resistance in women
    • Gotoh M, Mizuno K, Ono Y, Takahashi M. High blood pressure, bone-mineral loss and insulin resistance in women. Hypertens Res 2005; 28: 565-70.
    • (2005) Hypertens Res , vol.28 , pp. 565-570
    • Gotoh, M.1    Mizuno, K.2    Ono, Y.3    Takahashi, M.4
  • 32
    • 0034456567 scopus 로고    scopus 로고
    • Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase
    • Simoncini T, Genazzani AR. Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase. J Clin Endocrinol Metab 2000; 85: 2966-9.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2966-2969
    • Simoncini, T.1    Genazzani, A.R.2
  • 33
    • 0033533491 scopus 로고    scopus 로고
    • Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism
    • Figtree GA, Lu Y, Webb CM, Collins P. Raloxifene acutely relaxes rabbit coronary arteries in vitro by an estrogen receptor-dependent and nitric oxide-dependent mechanism. Circulation 1999; 100: 1095-101.
    • (1999) Circulation , vol.100 , pp. 1095-1101
    • Figtree, G.A.1    Lu, Y.2    Webb, C.M.3    Collins, P.4
  • 34
    • 0033781590 scopus 로고    scopus 로고
    • Effect of hormone replacement therapy on age-related increase in carotid artery intima-media thickness in postmenopausal women
    • Tremollieres FA, Cigagna F, Alquier C, Cauneille C, Pouilles J, Ribot C. Effect of hormone replacement therapy on age-related increase in carotid artery intima-media thickness in postmenopausal women. Atherosclerosis 2000; 153: 81-8.
    • (2000) Atherosclerosis , vol.153 , pp. 81-88
    • Tremollieres, F.A.1    Cigagna, F.2    Alquier, C.3    Cauneille, C.4    Pouilles, J.5    Ribot, C.6
  • 35
    • 0020442636 scopus 로고
    • Cell density and estradiol modulation of procollagen type III in cultured calf smooth muscle cells
    • Beldekas JC, Gerstenfeld L, Sonenshein GE, Franzblau C. Cell density and estradiol modulation of procollagen type III in cultured calf smooth muscle cells. J Biol Chem 1982; 257: 12252-6.
    • (1982) J Biol Chem , vol.257 , pp. 12252-12256
    • Beldekas, J.C.1    Gerstenfeld, L.2    Sonenshein, G.E.3    Franzblau, C.4
  • 36
    • 0021948946 scopus 로고
    • Effects of estradiol and progesterone on the increased synthesis of collagen in atherosclerotic rabbit aortas
    • Fischer GM, Swain ML. Effects of estradiol and progesterone on the increased synthesis of collagen in atherosclerotic rabbit aortas. Atherosclerosis 1985; 54: 177-85.
    • (1985) Atherosclerosis , vol.54 , pp. 177-185
    • Fischer, G.M.1    Swain, M.L.2
  • 37
    • 0031606441 scopus 로고    scopus 로고
    • 17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth
    • Dubey RK, Gillespie DG, Jackson EK, Keller PJ. 17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth. Hypertension 1998; 31: 522-8.
    • (1998) Hypertension , vol.31 , pp. 522-528
    • Dubey, R.K.1    Gillespie, D.G.2    Jackson, E.K.3    Keller, P.J.4
  • 38
    • 0032547326 scopus 로고    scopus 로고
    • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    • Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998; 280: 605-13.
    • (1998) JAMA , vol.280 , pp. 605-613
    • Hulley, S.1    Grady, D.2    Bush, T.3
  • 39
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial
    • Writing Group for the Women's Health Initiative Investigators
    • Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33.
    • (2002) JAMA , vol.288 , pp. 321-333
  • 40
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial
    • Women's Health Initiative Steering Committee
    • Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004; 291: 1701-12.
    • (2004) JAMA , vol.291 , pp. 1701-1712
  • 41
    • 0037190065 scopus 로고    scopus 로고
    • Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the Women's Health Initiative observational study
    • Pradhan AD, Manson JE, Rossouw JE, et al. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA 2002; 288: 980-7.
    • (2002) JAMA , vol.288 , pp. 980-987
    • Pradhan, A.D.1    Manson, J.E.2    Rossouw, J.E.3
  • 42
    • 0032566401 scopus 로고    scopus 로고
    • Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women
    • Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-3.
    • (1998) Circulation , vol.98 , pp. 731-733
    • Ridker, P.M.1    Buring, J.E.2    Shih, J.3    Matias, M.4    Hennekens, C.H.5
  • 43
    • 77957126077 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Intervention (PEPI) Trial
    • The Writing Group for the PEPI Trial
    • The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Intervention (PEPI) Trial. JAMA 1995; 273: 199-208.
    • (1995) JAMA , vol.273 , pp. 199-208
  • 45
    • 2642712522 scopus 로고    scopus 로고
    • Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women
    • Walsh BW, Kuller LH, Wild RA, et al. Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA 1998; 279: 1445-51.
    • (1998) JAMA , vol.279 , pp. 1445-1451
    • Walsh, B.W.1    Kuller, L.H.2    Wild, R.A.3
  • 47
    • 0034456409 scopus 로고    scopus 로고
    • The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: A randomized, controlled trial
    • Walsh BW, Paul S, Wild RA, et al. The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab 2000; 85: 214-8.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 214-218
    • Walsh, B.W.1    Paul, S.2    Wild, R.A.3
  • 49
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Review
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-9. (Review)
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 50
    • 1242328760 scopus 로고    scopus 로고
    • Interrelationship between non-invasive measurements of atherosclerosis: Flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity
    • Kobayashi K, Akishita M, Yu W, Hashimoto M, Ohni M, Toba K. Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity. Atherosclerosis 2004; 173: 13-8.
    • (2004) Atherosclerosis , vol.173 , pp. 13-18
    • Kobayashi, K.1    Akishita, M.2    Yu, W.3    Hashimoto, M.4    Ohni, M.5    Toba, K.6


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