A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis

Journal of Endocrinology

Volumn 204, Issue 3, 2010, Pages 241-253

  DeMambro, Victoria E ^a   Kawai, Masanobu ^b   Clemens, Thomas L ^c   Fulzele, Keertik ^d   Maynard, Jane A ^a   De Evsikova, Caralina Marín ^a   Johnson, Kenneth R ^a   Canalis, Ernesto ^e   Beamer, Wesley G ^a   Rosen, Clifford J ^b   Donahue, Leah Rae ^a  

^a JACKSON LABORATORY   (United States)

^b Medical Center Research Institute   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; SOMATOMEDIN;

ADIPOGENESIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MASS; CONTROLLED STUDY; FEMALE; GENE; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; HYPERINSULINEMIA; IRS1 GENE; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOPOROSIS; PHENOTYPE; PRIORITY JOURNAL; SHORT STATURE; SPONTANEOUS MUTATION;

ADIPOGENESIS; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DEVELOPMENT; CELLS, CULTURED; FEMALE; HYPERINSULINISM; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MUTATION; OSTEOCLASTS; SIGNAL TRANSDUCTION;

EID: 76649143751     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0328     Document Type: Article

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