Ex vivo transfer of the Hoxc-8-interacting domain of smad1 by a tropism-modified adenoviral vector results in efficient bone formation in a rabbit model of spinal fusion

Journal of Spinal Disorders and Techniques

Volumn 23, Issue 1, 2010, Pages 63-73

  Douglas, Joanne T ^a,b,c   Rivera, Angel A ^a   Lyons, Gray R ^d   Lott, Patricia F ^e   Wang, Dezhi ^e   Zayzafoon, Majd ^c,d   Siegal, Gene P ^b,c,d   Cao, Xu ^c,d   Theiss, Steven M ^c,e  

^a Division of Human Gene Therapy   (United States)

^b Gene Therapy Center   (Switzerland)

^c Center for Metabolic Bone Disease   (United States)

^d Department of Pathology ^*

^e Mayo Clinic College of Medicine   (United States)

Author keywords

Adenoviral vector; Bone marrow stromal cell; Gene transfer; Rabbit; Spinal fusion

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; ALPHA5 INTEGRIN; BETA GALACTOSIDASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; GELATIN SPONGE; NUCLEIC ACID BINDING PROTEIN; SMAD1 PROTEIN; SMAD1C PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL DIFFERENTIATION; CELL NUCLEUS; COMPUTER PROGRAM; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; EXPERIMENTAL MODEL; EXPERIMENTAL RABBIT; FEMALE; GENE TRANSFER; HUMAN; HUMAN ADENOVIRUS 5; HUMAN CELL; IMAGE ANALYSIS; LUMBAR VERTEBRA; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPINE FUSION; STAINING; STROMA CELL; VERTEBRA;

ADENOVIRIDAE; ANIMALS; BONE MARROW TRANSPLANTATION; BONE REGENERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HOMEODOMAIN PROTEINS; INTEGRIN ALPHAV; PROTEIN STRUCTURE, TERTIARY; RABBITS; SMAD1 PROTEIN; SPINAL FUSION; STROMAL CELLS; TREATMENT OUTCOME;

EID: 76649132977     PISSN: 15360652     EISSN: None     Source Type: Journal    
DOI: 10.1097/BSD.0b013e318193b693     Document Type: Article

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