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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1718-1720

Design, synthesis, evaluation and QSAR analysis of N1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

(12) Takahashi, Jun a Hijikuro, Ichiro c Kihara, Takeshi a Murugesh, Modachur G c Fuse, Shinichiro b Kunimoto, Ryo a Tsumura, Yoshinori a Akaike, Akinori a Niidome, Tetsuhiro a Okuno, Yasushi a Takahashi, Takashi b Sugimoto, Hachiro a

a KYOTO UNIVERSITY (Japan)

b TOKYO INSTITUTE OF TECHNOLOGY (Japan)

c ChemGenesis Incorporated (Japan)

Author keywords

Acetylcolinesterase; Alzheimer's disease; Butyrylcholinesterase; Carbamate

Indexed keywords

CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CYMSERINE; N1 PHENETHYLNORCYMSERINE; NORCYMSERINE DERIVATIVE; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CARBAMATES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; NEUROPROTECTIVE AGENTS; PHYSOSTIGMINE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76649093904 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.01.057 Document Type: Article

Times cited : (18)

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