Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 2, 2010, Pages 175-180

  Lee, Yong Jae ^a   Lee, Hye Ree ^a   Lee, Jung Hyun ^b   Shin, Youn Ho ^c   Shim, Jae Yong ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c CHA University   (South Korea)

Author keywords

Inflammation; Insulin resistance; Non alcoholic fatty liver disease; Uric acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD VESSEL; BODY MASS; CHOLESTEROL BLOOD LEVEL; CIGARETTE SMOKING; CONTROLLED STUDY; CORRELATIONAL STUDY; DIABETES MELLITUS; DIAPHRAGM; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; EXERCISE; FATTY LIVER; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HUMAN; HYPERTENSION; KOREA; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; ULTRASOUND; URIC ACID BLOOD LEVEL;

ADULT; AGE FACTORS; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CITIES; EXERCISE; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; LIPIDS; MALE; MIDDLE AGED; ODDS RATIO; REPUBLIC OF KOREA; SEX FACTORS; SMOKING; URIC ACID; YOUNG ADULT;

EID: 76649083261     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.037     Document Type: Article

References (30)

1. Harrison R. Structure and function of xanthine oxidoreductase: where are we now? Free Radic Biol Med 2002;33:774-797
2. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 2008;27:608-619
3. Bos MJ, Koudstaal PJ, Hofman A, Witteman JC, Breteler MM. Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study. Stroke 2006;37:1503-1507 (Pubitemid 44305733)
4. Dehghan A, van Hoek M, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care 2008;31:361-362
5. Lohsoonthorn V, Dhanamun B, Williams MA. Prevalence of hyperuricemia and its relationship with metabolic syndrome in Thai adults receiving annual health exams. Arch Med Res 2006;37:883-889
6. Sui X, Church TS, Meriwether RA, Lobelo F, Blair SN. Uric acid and the development of metabolic syndrome in women and men. Metabolism 2008;57:845-852
7. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340:115-126
8. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-867
9. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999; 116:1413-1419
10. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of non-alcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129:113-121
11. Angulo P. GI epidemiology: non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2007;25:883-889
12. Park SH, Kim BI, Yun JW, Kim JW, Park DI, Cho YK, et al. Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men. J Gastroenterol Hepatol 2004;19:694-698
13. Chang Y, Ryu S, Sung E, Jang Y. Higher concentrations of alanine aminotransferase within the reference interval predict non-alcoholic fatty liver disease. Clin Chem 2007;53:686-692
14. Lee YJ, Kim JK, Lee JH, Lee HR, Kang DR, Shim JY. Association of serum g-glutmyltransferase with C-reactive protein concentrations and white blood cell count in Korean adults. Clin Chem Lab Med 2008;46:1410-1415
15. Lee YJ, Lee JH, Shin YH, Kim JK, Lee HR, LEE DC. Gender difference and determinants of C-reactive protein level in Korean adults. Clin Chem Lab Med 2009;47:863-869
16. Fallo F, Dalla Pozza A, Sonino N, Federspil G, Ermani M, Baroselli S, et al. Non-alcoholic fatty liver disease, adiponectin and insulin resistance in dipper and non-dipper essential hypertensive patients. J Hypertens 2008;26:2191-2197
17. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, et al. American college of endocrinology position statement on the insulin resistance syndrome. Endocr Pract 2003;9:237-252
18. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for non-alcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005;42:44-52.
19. Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, Oren R. Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006;26:856-863
20. Jimba S, Nakagami T, Takahashi M, Wakamatsu T, Hirota Y, Iwamoto Y, et al. Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med 2005;22:1141-1145
21. Shi JP, Fan JG, Wu R, Gao XQ, Zhang L, Wang H, et al. Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis B infection. J Gastroenterol Hepatol 2008;23:1419-1425
22. Li Y, Xu C, Yu C, Yu C, Xu L, Miao M. Association of serum uric acid level with non-alcoholic fatty liver disease: a crosssectional study. J Hepatol 2009;50:1029-1034
23. Yoo TW, Sung KC, Shin HS, Kim BJ, Kim BS, Kang JH, et al. Relationship between serum uric acid concentration and insuline resistance and metabolic syndrome. Circ J 2005;69: 928-933
24. Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS. Elevated serum uric acid level in metabolic syndrome: an active component or an innocent bystander? Metabolism 2006;55:1293-1301
25. Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 2007;120:442-447
26. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension 2003;41:1287-1293
27. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995;95:2409-2415
28. Ruggiero C, Cherubini A, Ble A, Bos AJ, Maggio M, Dixit VD, et al. Uric acid and inflammatory markers. Eur Heart J 2006;27:1174-1181
29. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham heart study. Ann Intern Med 1999;131:7-13.
30. Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Br Med J 1986;292:13-15