Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 10, 2008, Pages 1410-1415

  Lee, Yong Jae ^a   Kim, Jong Koo ^a   Lee, Jung Hyun ^b   Lee, Hye Ree ^a   Kang, Dae Ryong ^a   Shim, Jae Yong ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

glutamyltransferase; C reactive protein; Cardiovascular disease; Inflammation; White blood cell count

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD PRESSURE; BODY MASS; C REACTIVE BLOOD LEVEL; CARDIOVASCULAR DISEASE; DISEASE MARKER; ETHNIC GROUP; EXERCISE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; KOREAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SMOKING;

ADULT; AGED; C-REACTIVE PROTEIN; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HEALTH; HOSPITALS; HUMANS; KOREA; LEUKOCYTE COUNT; MALE; MIDDLE AGED; RISK ASSESSMENT; YOUNG ADULT;

EID: 53849123305     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.280     Document Type: Article

References (28)

1. Stark AA, Porat N, Volohonsky G, Komlosh A, Bluvshtein E, Tubi C, et al. The role of gammaglutamyl transpeptidase in the biosynthesis of glutathione. Biofacotors 2003;17:139-49.
2. Whitfield JB. Gamma gutamyl transferase. Crit Rev Clin Lab Sci 2001;38:263-355.
3. Drozdz R, Parmentier C, Hachad H, Leroy P, Siest G, Wellman M. Gamma-Glutamyltransferase dependent generation of reactive oxygen species from glutathione/transferrin system. Free Radic Biol Med 1998;25:786-92.
4. Lee DH, Silventoinen K, Hu G, Jacobs DR Jr, Jousilahti P, Sundvall J, et al. Serum gammaglutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women. Eur Heart J 2006;27:2170-6.
5. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H, et al. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological and investigation in a cohort of 163,944 Austrian adults. Circulation 2005;112;2130-7.
6. Ross R. Atherosclerosis, an inflammatory disease. N Engl J Med 1999;340:115-26.
7. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43.
8. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow up of 14,719 initially healthy American women. Circulation 2003;107:391-7.
9. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004;350:1387-97.
10. Lee CD, Folsom AR, Nieto FJ, Chambless LE, Shahar E, Wolfe DA. White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and white men and women: Atherosclerosis Risk in Communities Study. Am J Epidemiol 2001;154:758-64.
11. Lee DH, Jacobs DR Jr. Association between serum gamma-glutamyltransferase and C-reactive protein. Atherosclerosis 2005;178:327-30.
12. Bo S, Gambino R, Durazzo M, Guidi S, Tiozzo E, Ghione F, et al. Associations between gamma-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: a possible implication for oxidative stress. World J Gastroenterol 2005;11:7109-17.
13. Schiele F, Guilmin AM, Detienne H, Siest G. Gamma-glutamyltransferase activity in plasma: statistical distributions, individual variations, and reference intervals. Clin Chem 1997:23:1023-8.
14. Yamada J, Tomiyama H, Yambe M, Koji Y, Motobe K, Shiina K, et al. Elevated serum levels of alanine aminotransferase and gamma glutamyltransferase are markers of inflammation and oxidative stress independent of the metabolic syndrome. Atherosclerosis 2006;189:198-205.
15. Ortega E, Koska J, Salbe AD, Tataranni PA, Bunt JC. Serum gamma-glutamyl transpeptidase is a determinant of insulin resistance independently of adiposity in Pima Indian children. J Clin Endocrinol Metab 2006;91:1419-22.
16. Sakuta H, Suzuki T, Yasuda H, Ito T. White blood cell count is associated with plasma total homocysteine in Japanese men. Scand J Clin Lab Invest 2005;65:447-52.
17. Nilssen O, Førde OH, Brenn T. The Tromsø Study. Distribution and population determinants of gamma-glutamyltransferase. Am J Epidemiol 1990;132:318-26.
18. Nystrom E, Bengtsson C, Lindstedt G, Lapidus L, Lindquist O, Waldenstrom J. Serum gammaglutamyltransferase in a Swedish female population. Age-related reference intervals; morbidity and progress in cases with raised catalytic concentration. Acta Med Scand 1988;224:79-84.
19. Nakanishi N, Suzuki K, Tatara K. Serum γ-glutamyltransferase and risk of metabolic syndrome and type 2 diabetes in middle-aged Japanese men. Diabetes Care 2004;27:1427-32.
20. Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995;142:699-708.
21. André P, Charles MA, Balkau B, Eschwège E, Vol S. Gamma-glutamyltransferase activity and development of the metabolic syndrome (International Diabetes Federation definition) in middle-aged men and women: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort. Diabetes Care 2007;30:2355-61.
22. Lao XQ, Thomas GN, Jiang CQ, Zhang WS, Yin P, Adab P, et al. C-reactive protein and the metabolic syndrome in older Chinese: Guangzhou Biobank Cohort Study. Atherosclerosis 2007;194:483-9.
23. Enoiu M, Aberkane H, Salazar JF, Leroy P, Groffen J, Siest G, et al. Evidence for the pro-oxidant effect of γ-glutamyltransferase-related enzyme. Free Radic Biol Med 2000;29:825-33.
24. Stark AA, Glass GA. Role of copper and ceruloplasmin in oxidative mutagenesis induced by the glutathione-gamma-glutamyl transpeptidase system and by other thiols. Environ Mol Mutagen 1997;29:63-72.
25. Glass GA, Stark AA. Promotion of glutathione-gamma- glutamyltranspeptidase-dependent lipid peroxidation by copper and ceruloplasmin: the requirement for iron and the effects of antioxidants and antioxidant enzymes. Environ Mol Mutagen 1997;29:73-80.
26. Paolicchi A, Minotti G, Tonarelli P, Tongiani R, De Cesare D, Mezzetti A, et al. Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation: a potential mechanism in atherosclerosis, J Invest Med 1999;47:151-60.
27. Paolicchi A, Emdin A, Ghliozeni E, Ciancia E, Passino C, Popoff G, et al. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity. Circulation 2004;109:1440.
28. Lee DH, Gross M, Jacobs DR Jr. Association of serum carotenoids and tocopherols with gamma glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) study. Clin Chem 2004;50:582-8.