Novel molecular insights into the mechanism of GO removal by MutM

Cell Research

Volumn 20, Issue 2, 2010, Pages 116-118

  Li, Guo Min ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,8-DIHYDRO-8-OXOGUANINE; 8 HYDROXYGUANINE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE, E COLI; DNA GLYCOSYLTRANSFERASE; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE, E COLI; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; GUANINE; OXOGUANINE GLYCOSYLASE 1, HUMAN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; DNA REPAIR; ESCHERICHIA COLI; EUKARYOTIC CELL; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DNA GLYCOSYLASES; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; GUANINE; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 76449122360     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.15     Document Type: Article

References (13)

1. Hegde ML, Hazra TK, Mitra S. Early steps in the DNA base excision/singlestrand interruption repair pathway in mammalian cells. Cell Res 2008; 18:27-47.
2. Paz-Elizur T, Sevilya Z, Leitner-Dagan Y, et al. DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention. Cancer Lett 2008; 266:60-72.
3. Lu AL, Bai H, Shi G, Chang DY. MutY and MutY homologs (MYH) in genome maintenance. Front Biosci 2006; 11:3062-3080.
4. Bruner SD, Norman DP, Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature 2000; 403:859-866.
5. Fromme JC, Verdine GL. DNA lesion recognition by the bacterial repair enzyme MutM. J Biol Chem 2003; 278:51543-51548.
6. Qi Y, Spong MC, Nam K, et al. Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature 2009; 462:762-766.
7. Plum GE, Grollman AP, Johnson F, npg Breslauer KJ. Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex. Biochemistry 1995; 34:16148-16160.
8. Qi Y, Spong MC, Nam K, Karplus M, Verdine GL. Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. J Biol Chem 2010 285:1468-1478.
9. Blainey PC, van Oijen AM, Banerjee A, Verdine GL, Xie XS. A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci USA 2006; 103:5752-5757.
10. Li GM. Mechanisms and functions of DNA mismatch repair. Cell Res 2008; 18:85-98.
11. Sancar A, Sancar GB. DNA repair enzymes. Ann Rev Biochem 1988; 57:29-67.
12. Yang W. Structure and mechanism for DNA lesion recognition. Cell Res 2008; 18:184-197.
13. Parker JB, Bianchet MA, Krosky DJ, et al. Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature 2007; 449:433-437.