Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 496-507

  Abdel Bar, Fatma M ^a,b   Khanfar, Mohammad A ^a,b   Elnagar, Ahmed Y ^a,b   Badria, Farid A ^a,b   Zaghloul, Ahmed M ^a,b   Ahmad, Kadria F ^a,b   Sylvester, Paul W ^a,b   El Sayed, Khalid A ^a,b  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Anti invasive; Biaryl; Breast cancer; Heck and Suzuki coupling reactions; Methyl eugenol; Microtubules; Pharmacophore modeling

Indexed keywords

1,2 DIMETHOXY 4 [2 (4 METHOXYPHENYL)ALLYL]BENZENE; 1,2 DIMETHOXY 4 [3 (4 METHOXYPHENYL)ALLYL]BENZENE; 1,2 DIMETHOXY 4 [3 (4 METHOXYPHENYL)PROP 1 ENYL]BENZENE; 2 [3 (3,4 DIMETHOXYPHENYL)ALLYL] 1,3 DIMETHYLBENZENE; 2 [3 (3,4 DIMETHOXYPHENYL)PROP 1 EN 2 YL]PHENYL ACETATE; 2 [3 (3,4 DIMETHOXYPHENYL)PROP 1 ENYL] 1,3 DIMETHYLBENZENE; 2 [3 (3,4 DIMETHOXYPHENYL)PROP 1 PHENYL]PHENYL ACETATE; 2 [3(3,4 DIMETHOXYPHENYL)ALLYL]PHENYL ACETATE; 5 [3 (3,4 DIMETHOXYPHENYL)ALLYL] 1,2,3 TRIMETHOXYBENZENE; 5 [3 (3,4 DIMETHOXYPHENYL)PROP 1 EN 2 YL] 1,2,3 TRIMETHOXYBENZENE; 5 [3 (3,4 DIMETHOXYPHENYL)PROP 1 ENYL] 1,2,3 TRIMETHOXYBENZENE; 5[ 3 (3,4 DIMETHOXYPHENYL)ALLYL] 1,2,3 TRIMETHOXYBENZENE; COLCHICINE; ESSENTIAL OIL; EUGENOL; MELALEUCA ERICIFOLIA EXTRACT; PLANT EXTRACT; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CHEMICAL REACTION; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; HUMAN; HUMAN CELL; ISOMER; MEDICINAL PLANT; MELALEUCA ERICIFOLIA; METASTASIS; MICROTUBULE; PHARMACOPHORE; PLANT LEAF;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EUGENOL; FEMALE; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; NEOPLASM INVASIVENESS; STRUCTURE-ACTIVITY RELATIONSHIP;

MELALEUCA ERICIFOLIA; MYRTACEAE;

EID: 76449118921     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.019     Document Type: Article

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