Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: A meta-analysis of comparative trials

Critical Care

Volumn 10, Issue 4, 2006, Pages

  Falagas, Matthew E ^a,b,c   Siempos, Ilias I ^a   Bliziotis, Ioannis A ^a   Michalopoulos, Argyris ^b  

^a ALFA INSTITUTE OF BIOMEDICAL SCIENCES AIBS   (Greece)

^b HENRY DUNANT HOSPITAL   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFTAZIDIME; CEFUROXIME; COLISTIN; GENTAMICIN; METRONIDAZOLE; PLACEBO; POLYMYXIN B; TOBRAMYCIN; ANTIINFECTIVE AGENT;

AEROSOL; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LUNG LAVAGE; META ANALYSIS; MICROBIAL COLONIZATION; MORTALITY; MULTIPLE TRAUMA; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; SYSTEMATIC REVIEW; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; ANIMAL; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; CROSS INFECTION; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; RESPIRATORY SYSTEM;

ADMINISTRATION, INHALATION; ANIMALS; ANTI-BACTERIAL AGENTS; CLINICAL TRIALS AS TOPIC; CROSS INFECTION; HUMANS; INTENSIVE CARE UNITS; PNEUMONIA; RESPIRATORY SYSTEM;

EID: 34247551021     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc5032     Document Type: Article

References (37)

1. Dodek P Keenan S Cook D Heyland D Jacka M Hand L Muscedere J Foster D Mehta N Hall R Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia Ann Intern Med 2004 141 305-313 15313747
2. Kollef MH Micek ST Strategies to prevent antimicrobial resistance in the intensive care unit Crit Care Med 2005 33 1845-1853 10.1097/ 01.CCM.0000171849.04952.79 16096464
3. Tablan OC Anderson LJ Arden NH Breiman RF Butler JC McNeil MM Guideline for prevention of nosocomial pneumonia. The Hospital Infection Control Practices Advisory Committee, Centers for Disease Control and Prevention Infect Control Hosp Epidemiol 1994 15 587-627 7989733
4. Tablan OC Anderson LJ Besser R Bridges C Hajjeh R Guidelines for preventing health-care - associated pneumonia, 2003: Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee MMWR Recomm Rep 2004 53 1-36 15048056
5. Jadad AR Moore RA Carroll D Jenkinson C Reynolds DJ Gavaghan DJ McQuay HJ Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996 17 1-12 10.1016/ 0197-2456(95)00134-4 8721797
6. DerSimonian R Laird N Meta-analysis in clinical trials Control Clin Trials 1986 7 177-188 10.1016/0197-2456(86)90046-2 3802833
7. Mantel N Mocarelli P Marocchi A Brambilla P Baretta R Stratified analysis of multivariate clinical data: Application of a Mantel-Haenszel approach Stat Med 1983 2 259-266 6648140
8. Mantel N Haenszel W Statistical aspects of the analysis of data from retrospective studies of disease J Natl Cancer Inst 1959 22 719-748 13655060
9. Egger M Davey SG Schneider M Minder C Bias in meta-analysis detected by a simple, graphical test BMJ 1997 315 629-634 9310563
10. Feeley TW Du Moulin GC Hedley-Whyte J Bushnell LS Gilbert JP Feingold DS Aerosol polymyxin and pneumonia in seriously ill patients N Engl J Med 1975 293 471-475 168487
11. Greenfield S Teres D Bushnell LS Hedley-Whyte J Feingold DS Prevention of gram-negative bacillary pneumonia using aerosol polymyxin as prophylaxis. I. Effect on the colonization pattern of the upper respiratory tract of seriously ill patients J Clin Invest 1973 52 2935-2940 302562 4356004
12. Hoth JJ Franklin GA Stassen NA Girard SM Rodriguez RJ Rodriguez JL Prophylactic antibiotics adversely affect nosocomial pneumonia in trauma patients J Trauma 2003 55 249-254 12913633
13. Klastersky J Huysmans E Weerts D Hensgens C Daneau D Endotracheally administered gentamicin for the prevention of infections of the respiratory tract in patients with tracheostomy: A double-blind study Chest 1974 65 650-654 4208908
14. Klastersky J Hensgens C Noterman J Mouawad E Meunier-Carpentier F Endotracheal antibiotics for the prevention of tracheobronchial infections in tracheotomized unconscious patients. A comparative study of gentamicin and aminosidin-polymyxin B combination Chest 1975 68 302-306 169104
15. Klick JM du Moulin GC Hedley-Whyte J Teres D Bushnell LS Feingold DS Prevention of gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients J Clin Invest 1975 55 514-519 301778 163848
16. Lepper MH Kofman S Blatt N Dowling HF Jackson GG Effect of eight antibiotics used singly and in combination on the tracheal flora following tracheotomy in poliomyelitis Antibiot Chemother 1954 4 829-843
17. Lode H Hoffken G Kemmerich B Schaberg T Systemic and endotracheal antibiotic prophylaxis of nosocomial pneumonia in ICU Intensive Care Med 1992 18 Suppl 1 S24-S27 10.1007/BF01752973 1640029
18. Rathgeber J Zielmann S Panzer C Burchardi H [Prevention of pneumonia by endotracheal micronebulization of tobramycin] Anasthesiol Intensivmed Notfallmed Schmerzther 1993 28 23-29 8467027
19. Rouby JJ Poete P Martin dL Nicolas MH Bodin L Jarlier V Korinek AM Viars P Prevention of gram negative nosocomial bronchopneumonia by intratracheal colistin in critically ill patients. Histologic and bacteriologic study Intensive Care Med 1994 20 187-192 10.1007/ BF01704698 8014284
20. Vogel F Werner H Exner M Marx M [Prophylaxis and treatment of respiratory tract infection in ventilated patients by endotracheal administration of aminoglycosides (author's transl)] Dtsch Med Wochenschr 1981 106 898-903 7238342
21. Wood GC Boucher BA Croce MA Hanes SD Herring VL Fabian TC Aerosolized ceftazidime for prevention of ventilator-associated pneumonia and drug effects on the proinflammatory response in critically ill trauma patients Pharmacotherapy 2002 22 972-982 10.1592/phco.22.12.972.33596 12173800
22. Crouch TW Higuchi JH Coalson JJ Johanson WG Jr Pathogenesis and prevention of nosocomial pneumonia in a nonhuman primate model of acute respiratory failure Am Rev Respir Dis 1984 130 502-504 6476598
23. Le Conte P Potel G Peltier P Horeau D Caillon J Juvin ME Kergueris MF Bugnon D Baron D Lung distribution and pharmacokinetics of aerosolized tobramycin Am Rev Respir Dis 1993 147 1279-1282 8484643
24. Odio W Van Laer E Klastersky J Concentrations of gentamicin in bronchial secretions after intramuscular and endotracheal administration J Clin Pharmacol 1975 15 518-524 807603
25. Wood GC Boucher BA Aerosolized antimicrobial therapy in acutely ill patients Pharmacotherapy 2000 20 166-181 10.1592/phco.20.3.166.34783 10678295
26. Orriols R Roig J Ferrer J Sampol G Rosell A Ferrer A Vallano A Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa Respir Med 1999 93 476-480 10.1016/S0954-6111(99)90090-2 10464834
27. Drobnic ME Sune P Montoro JB Ferrer A Orriols R Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa Ann Pharmacother 2005 39 39-44 15562142
28. Barker AF Couch L Fiel SB Gotfried MH Ilowite J Meyer KC O'Donnell A Sahn SA Smith LJ Stewart JO Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis Am J Respir Crit Care Med 2000 162 481-485 10934074
29. Marschke G Sarauw A Danger of polymyxin B inhalation Ann Intern Med 1971 74 296-297 4322737
30. Melani AS Di Gregorio A Acute respiratory failure due to gentamicin aerosolization Monaldi Arch Chest Dis 1998 53 274-276 9785810
31. Paterson JW Sudlow MF Walker SR Blood-levels of fluorinated hydrocarbons in asthmatic patients after inhalation of pressurised aerosols Lancet 1971 2 565-568 10.1016/S0140-6736(71)92149-0 4106103
32. Levine BA Petroff PA Slade CL Pruitt BA Jr Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient J Trauma 1978 18 188-193 347099
33. Brown RB Phillips D Barker MJ Pieczarka R Sands M Teres D Outbreak of nosocomial Flavobacterium meningosepticum respiratory infections associated with use of aerosolized polymyxin B Am J Infect Control 1989 17 121-125 10.1016/0196-6553(89)90197-1 2545119
34. Alothman GA Ho B Alsaadi MM Ho SL O'Drowsky L Louca E Coates AL Bronchial constriction and inhaled colistin in cystic fibrosis Chest 2005 127 522-529 10.1378/chest.127.2.522 15705991
35. Marschke G Sarauw A Polymyxin inhalation therapeutic hazard Ann Intern Med 1971 74 144-145 4321710
36. Falagas ME Bliziotis IA Siempos II Attributable mortality of Acinetobacter baumannii infections in critically ill patients: A systematic review of matched cohort and case-control studies Crit Care 2006 10 R48 1550903 16563184 10.1186/cc4869
37. Hamer DH Barza M Prevention of hospital-acquired pneumonia in critically ill patients Antimicrob Agents Chemother 1993 37 931-938 187853 8517719