Poor lymphoproliferative responses with low proportion of gag-specific CD8 TEMRA cells in HIV-1-infected patients showing immunological and virological discordance despite prolonged suppression of plasma viremia

Viral Immunology

Volumn 23, Issue 1, 2010, Pages 49-61

  Sachdeva, Naresh ^a   Weinstein, Jessica E ^a   Ashman, Margarita ^a   Sachdeva, Meenakshi ^d   Brewer, Toye H ^b   Gracia, Deborah ^c   Asthana, Deshratn ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c Borinquen Health Care Center   (United States)

^d POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 2; PERFORIN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PLASMA; PROTEIN SECRETION; VIREMIA;

ADULT; AGED; ANIMALS; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CANDIDA ALBICANS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; TETANUS TOXOID; VIRAL LOAD; VIREMIA; YOUNG ADULT;

CANDIDA ALBICANS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 76449113777     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2009.0069     Document Type: Article

References (43)

1. Schechter M, and Tuboi SH: Discordant immunological and virological responses to antiretroviral therapy. J Antimicrob Chemother 2006;58:506-510.
2. Spritzler J, Mildvan D, Russo A, et al.: Can immune markers predict subsequent discordance between immunologic and virologic responses to antiretroviral therapy? Adult AIDS Clinical Trials Group. Clin Infect Dis 2003;37:551-558.
3. Marchetti G, Gori A, Casabianca A, et al.: Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART. AIDS 2006;20:1727-1736.
4. Marziali M, De Santis W, Carello R, et al.: T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART. AIDS 2006;20:2033-2041.
5. Sun JC, and Bevan MJ: Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 2003;300:339-342.
6. Prlic M, Williams MA, and Bevan MJ: Requirements for CD8 T-cell priming, memory generation and maintenance. Curr Opin Immunol 2007;19:315-319.
7. Sallusto F, Lenig D, Forster R, Lipp M, and Lanzavecchia A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712.
8. Koch S, Larbi A, Derhovanessian E, Ozcelik D, Naumova E, and Pawelec G: Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Aging 2008;25:6.
9. Sprent J, Judge AD, and Zhang X: Cytokines and memoryphenotype CD8+cells. Adv Exp Med Biol 2002;512:147-153.
10. Kaech SM, and Ahmed R: Immunology. CD8 T cells remember with a little help. Science 2003;300:263-265.
11. Wherry EJ, and Ahmed R: Memory CD8 T-cell differentiation during viral infection. J Virol 2004;78:5535-5545. (Pubitemid 38661640)
12. Harari A, Enders FB, Cellerai C, Bart PA, and Pantaleo G.: Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J Virol 2009;83:2862-2871.
13. Janssen EM, Droin NM, Lemmens EE, et al.: CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 2005;434:88-93.
14. Appay V, Nixon DF, Donahoe SM, et al.: HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 2000;192:63-75.
15. Appay V, Papagno L, Spina CA, et al.: Dynamics of T cell responses in HIV infection. J Immunol 2002;168:3660-3666.
16. Champagne P, Ogg GS, King AS, et al.: Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001; 410:106-111.
17. Sachdeva N, Ashman M, Davila L, Brewer T, and Asthana D: T- and dendritic cell subsets associated with immunological and virological discordance in HIV-1 infected patients [A:151]. Presented at the XIV Conference on Retroviruses and Opportunistic Infections (CROI), 2007, Los Angeles.
18. Sachdeva N, Yoon HS, Oshima K, Garcia D, Goodkin K, and Asthana D: Biochip array-based analysis of plasma cytokines in HIV patients with immunological and virological discordance. Scand J Immunol 2007;65:549-554.
19. Kiepiela P, Ngumbela K, Thobakgale C, et al.: CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med 2007;13:46-53.
20. Romero P, Zippelius A, Kurth I, et al.: Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol 2007;178:4112-4119.
21. Sarkar S, Teichgraber V, Kalia V, et al.: Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol 2007;179:6704-6714.
22. Sun JC, Williams MA, and Bevan MJ: CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 2004;5:927-933.
23. Ramsburg EA, Publicover JM, Coppock D, and Rose JK: Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent. J Immunol 2007;178:6350-6358.
24. Rinaldo Jr CR, Liebmann JM, Huang XL, et al.: Prolonged suppression of human immunodeficiency virus type 1 (HIV- 1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens. J Infect Dis 1999;179:329-336.
25. D'Ettorre G, Forcina G, Andreotti M, et al.: Discordant response to antiretroviral therapy: HIV isolation, genotypic mutations, T-cell proliferation and cytokine production. AIDS 2002;16:1877-1885.
26. Recher M, Lang KS, Navarini A, et al.: Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med 2007;13:1316-1323.
27. Potter SJ, Lacabaratz C, Lambotte O, et al.: Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J Virol 2007;81:13904-13915.
28. Younes SA, Yassine-Diab B, Dumont AR, et al.: HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med 2003;198:1909-1922.
29. Burgers WA, Riou C, Mlotshwa M, et al.: Association of HIVspecific and total CD8+ T memory phenotypes in subtype C HIV-1 infection with viral set point. J Immunol 2009;182:4751-4761.
30. Okoye A, Meier-Schellersheim M, Brenchley JM, et al.: Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 2007;204:2171-2185.
31. Wherry EJ, Teichgraber V, Becker TC, et al.: Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003;4:225-234.
32. Unsoeld H, Krautwald S, Voehringer D, Kunzendorf U, and Pircher H: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function. J Immunol 2002;169:638-641.
33. van Lier RA, ten Berge IJ, and Gamadia LE: Human CD8(+) T-cell differentiation in response to viruses. Nat Rev Immunol 2003;3:931-939.
34. Migueles SA, Laborico AC, Shupert WL, et al.: HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 2002;3:1061-1068.
35. Betts MR, Nason MC, West SM, et al.: HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 2006;107:4781-4789.
36. Addo MM, Draenert R, Rathod A, et al.: Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection. PLoS ONE 2007;2:e321.
37. Saez-Cirion A, Lacabaratz C, Lambotte O, et al.: HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc Natl Acad Sci USA 2007;104:6776-6781.
38. Bass HZ, Fahey JL, Nishanian P, et al.: Relation of impaired lymphocyte proliferative function to other major human immunodeficiency virus type 1-induced immunological changes. Clin Diagn Lab Immunol 1997;4:64-69.
39. Benveniste O, Flahault A, Rollot F, et al.: Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1- infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads. J Infect Dis 2005;191:1670-1679.
40. Goicoechea M, Smith DM, Liu L, et al.: Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis 2006;94: 29-37.
41. Geldmacher C, Gray C, Nason M, et al.: A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection. J Virol 2007;81:13809-13815.
42. Sachdeva N, Asthana V, Brewer TH, Garcia D, and Asthana D: Impaired restoration of plasmacytoid dendritic cells in HIV-1 infected patients with poor CD4 T cell reconstitution is associated with decrease in capacity to produce IFN-a but not proinflammatory cytokines. J Immunol 2008;181:2887-2897.
43. Mezzaroma I, Carlesimo M, Pinter E, et al.: Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease. AIDS 1999;13:1187-1193.