Preventive effect of preinduction of metallothionein on mutagenicity caused by benzo[a]pyrene

Journal of Health Science

Volumn 56, Issue 1, 2010, Pages 65-71

  Takaishi, Masaki ^a   Suzuki, Junko S ^b   Satoh, Masahiko ^a,c   Nagase, Hisamitsu ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Benzo a pyrene; Metallothionein; Micronucleated reticulocyte; Zinc

Indexed keywords

BENZO[A]PYRENE; CATALASE; CYTOCHROME P450 1A; GLUTATHIONE; METALLOTHIONEIN; SUPEROXIDE DISMUTASE; ZINC SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; INJECTION; LIVER LEVEL; MALE; MICRONUCLEUS; MOUSE; MOUSE STRAIN; MUTAGENICITY; NONHUMAN; PROTECTION; PROTEIN SYNTHESIS; THERAPY EFFECT; WILD TYPE;

ANIMALIA; MUS;

EID: 76249115408     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.56.65     Document Type: Article

References (40)

1. Kagi, J. H. and Schaffer, A. (1988) Biochemistry of metallothionein. Biochemistry, 27, 8509-8515.
2. Miles, A. T., Hawksworth, G. M., Beattie, J. H. and Rodilla, V. (2000) Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit. Rev. Biochem. Mol. Biol., 35, 35-70.
3. Thornalley, P. J. and Vasak, M. (1985) Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta, 827, 36-44.
4. Endresen, L. and Rugstad, H. E. (1987) Protective function of metallothionein against certain anticancer agents. Experientia Suppl., 52, 595-602.
5. Cai, L., Satoh, M., Tohyama, C. and Cherian, M. G. (1999) Metallothionein in radiation exposure: its induction and protective role. Toxicology, 132, 85-98.
6. Naganuma, A., Satoh, M., Koyama, Y. and Imura, N. (1985) Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice. Toxicol. Lett., 24, 203-207.
7. Satoh, M., Cherian, M. G., Imura, N. and Shimizu, H. (1994) Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis. Cancer Res., 54, 5255-5257.
8. Conrad, C. C., Walter, C. A., Richardson, A., Hanes, M. A. and Grabowski, D. T. (1997) Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice. J. Toxicol. Environ. Health, 52, 527-543.
9. Poswillo, D. E. and Cohen, B. (1971) Inhibition of carcinogenesis by dietary zinc. Nature (London), 231, 447-448.
10. Duncan, J. R. and Dreosti, I. E. (1975) Zinc intake, neoplastic DNA synthesis, and chemical carcinogenesis in rats and mice. J. Natl. Cancer Inst., 55, 195-196.
11. IARC working group on the evaluation of carcinogenic risks to humans (in preparation) Air pollution, Part 1, some non-heterocyclic polycyclic aromatic hydrocarbons and some related industrial exposure. IARC Monogr. Eval. Carcinog. Risks Hum., 92, in preparation.
12. Conney, A. H., Chang, R. L., Jerina, D. M. and Wei, S. J. (1994) Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite. Drug Metab. Rev., 26, 125-163.
13. Hattemer-Frey, H. A. and Travis, C. C. (1991) Benzo-a-pyrene: environmental partitioning and human exposure. Toxicol. Ind. Health, 7, 141-157.
14. Conney, A. H. (1982) Inducion of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. Cancer Res., 42, 4875-4917.
15. Weinstein, I. B., Jeffrey, A. M., Jennette, K. W., Blobstein, S. H., Harvey, R. G., Harris, C., Autrup, H., Kasai, H. and Nakanishi, K. (1976) Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science, 193, 592-595.
16. Penning, T. M., Ohnishi, S. T., Ohnishi, T. and Harvey, R. G. (1996) Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase. Chem. Res. Toxicol., 9, 84-92.
17. Takaishi, M., Sawada, M., Shimada, A., Suzuki, J. S., Satoh, M. and Nagase, H. (2009) Protective role of metallothionein in benzo[a]pyrene- induced DNA damage. J. Toxicol. Sci., 34, 449-458.
18. Michalska, A. E. and Choo, K. H. (1993) Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A., 90, 8088-8092.
19. Hayashi, M., Morita, T., Kodama, Y., Sofuni, T. and Ishidate, M., Jr. (1990) The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res., 245, 245-249.
20. Tohyama, C. and Shaikh, Z. A. (1981) Metallothionein in plasma and urine of cadmium-exposed rats determined by a single-antibody radioimmunoassay. Fundam. Appl. Toxicol., 1, 1-7.
21. Nishimura, H., Nishimura, N. and Tohyama, C. (1990) Localization of metallothionein in the genital organs of the male rat. J. Histochem. Cytochem., 38, 927-933.
22. Moron, M. S., Depierre, J. W. and Mannervik, B. (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta, 582, 67-78.
23. Aebi, H. (1984) Catalase in vitro. Methods Enzymol., 105, 121-126.
24. Shimada, T., Wunsch, R. M., Hanna, I. H., Sutter, T. R., Guengerich, F. P. and Gillam, E. M. (1998) Recombinant human cytochrome P450 1B1 expression in Escherichia coli. Arch. Biochem. Biophys., 357, 111-120.
25. 2-dG adduct in a 5′-TG versus a 5′-UG sequence: removal of the methyl group causes a modest decrease in the [G→T/G→A] mutational ratio. Mutagenesis, 20, 105-110.
26. Shimada, T., Hayes, C. L., Yamazaki, H., Amin, S., Hecht, S. S., Guengerich, F. P. and Sutter, T. R. (1996) Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res., 56, 2979-2984.
27. Wood, A. W., Levin, W., Lu, A. Y., Yagi, H., Hernandez, O., Jerina, D. M. and Conney, A. H. (1976) Metabolism of benzo[a]pyrene and benzo[a]pyrene derivatives to mutageneic products by highly purified hepatic microsomal enzymes. J. Biol. Chem., 251, 4882-4890.
28. Pelkonen, O. and Nebert, D. W. (1982) Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol. Rev., 34, 189-222.
29. Shimada, T., Inoue, K., Suzuki, Y., Kawai, T., Azuma, E., Nakajima, T., Shindo, M., Kurose, K., Sugie, A., Yamagishi, Y., Fujii-Kuriyama, Y. and Hashimoto, M. (2002) Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis, 23, 1199-1207.
30. Durnam, D. M. and Palmiter, R. D. (1984) Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers. Mol. Cell. Biol., 4, 484-491.
31. Satoh, M., Kondo, Y., Mita, M., Nakagawa, I., Naganuma, A. and Imura, N. (1993) Prevention of carcinogenicity of anticancer drugs by metallothionein induction. Cancer Res., 53, 4767-4768.
32. Itoh, S. and Shimada, H. (1996) Micronucleus induction by chromium and selenium, and suppression by metallothionein inducer. Mutat. Res., 367, 233-236.
33. Nakagawa, I., Nishi, E., Naganuma, A. and Imura, N. (1995) Effect of preinduction of metallothionein synthesis on clastogenicity of anticancer drugs in mice. Mutat. Res., 348, 37-43.
34. Satoh, M., Aoki, Y. and Tohyama, C. (1997) Protective role of metallothionein in renal toxicity of cis-platinum. Cancer Chemother. Pharmacol., 40, 358-362.
35. Shibuya, K., Suzuki, J. S., Kito, H., Naganuma, A., Tohyama, C. and Satoh, M. (2008) Protective role of metallothionein in bone marrow injury caused by X-irradiation. J. Toxicol. Sci., 33, 479-484.
36. Sullivan, P. D. (1985) Free radicals of benzo(a)pyrene and derivatives. Environ. Health Perspect., 64, 283-295.
37. Palmiter, R. D. (1994) Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. U.S.A., 91, 1219-1223.
38. Chubatsu, L. S. and Meneghini, R. (1993) Metallothionein protects DNA from oxidative damage. Biochem. J., 291, 193-198.
39. Miura, N., Satoh, M., Imura, N. and Naganuma, A. (1998) Protective effect of bismuth nitrate against injury to the bone marrow by γ-irradiation in mice: possible involvement of induction of metallothionein synthesis. J. Pharmacol. Exp. Ther., 286, 1427-1430.
40. Conrad, C. C., Grabowski, D. T., Walter, C. A., Sabia, M. and Richardson, A. (2000) Using MT(-/-) mice to study metallothionein and oxidative stress. Free Radic. Biol. Med., 28, 447-462.