Exploring the Conformation-Regulated function of Titin Kinase by mechanical pump and probe experiments with single molecules

Angewandte Chemie - International Edition

Volumn 49, Issue 6, 2010, Pages 1147-1150

  Puchner, Elias M ^a   Gaub, Hermann E ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Enzymes; Force spectroscopy; Scanning probe microscopy; Sensors; Single molecule studies

Indexed keywords

AFM; FORCE SPECTROSCOPY; MECHANICAL ACTIVATION; MECHANICAL PUMP; PUMP-AND-PROBE; SINGLE-MOLECULE; SINGLE-MOLECULE STUDIES;

CATALYSTS; ENZYMES; MOLECULES; PROBES; PUMPS; SCANNING PROBE MICROSCOPY; SENSORS;

CONFORMATIONS;

ADENOSINE TRIPHOSPHATE; CONNECTIN; MUSCLE PROTEIN; PROTEIN KINASE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; METHODOLOGY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

ADENOSINE TRIPHOSPHATE; HUMANS; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; MUSCLE PROTEINS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 76249114882     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.200905956     Document Type: Article

References (28)

1. G. Binnig, C. F. Ouate, C. Gerber, Phys. Rev. Lett. 1986, 56, 930.
2. M. Rief, M. Gautel, F. Oesterhelt, J. M. Fernandez, H. E. Gaub, Science 1997, 276, 1109.
3. E. M. Puchner, H. E. Gaub, Curr. Opin. Struct. Biol. 2009, 19, 605.
4. J. P. Junker, F. Ziegler, M. Rief, Science 2009, 323, 633.
5. J. M. Fernandez, H. Li, Science 2004, 303, 1674.
6. M. Schlierf, M. Rief, Angew. Chem. 2009, 121, 835;
7. Angew. Chem. Int. Ed. 2009, 48, 820.
8. S. Garcia-Manyes, L. Dougan, C. L. Badilla, J. Brujic. J. M. Fernandez, Proc. Natl. Acad. Sci. USA 2009, 106, 10534.
9. A. Valbuena, J., Oroz, R. Hervas, A. M. Vera, D. Rodriguez, M. Menendez, J. I. Sulkowska, M. Cieplak, M. Carrion-Vazquez, Proc. Natl. Acad. Sci. USA 2009, 106, 13791.
10. A. Grützner, S. Garcia-Manyes, S. Kotier, C. L. Badilla, J. M. Fernandez, W. A. Linke, Biophys. J. 2009, 97, 825.
11. D. N. Greene, T. Garcia, R. B. Sutton, K. M. Gernert, G. M. Benian, A. F. Oberhauser, Biophys. J. 2008, 95, 1360.
12. Y. Cao, M. M. Balamurali, D. Sharma, H. B. Li, Proc. Natl. Acad. Sci. USA 2007, 104, 15677.
13. M. Bertz, M. Rief, J. Mol. Biol. 2009, 393,1079.
14. A. P. Wiita, R. Perez-Jimenez, K. A. Walther, F. Grater, B. J. Berne, A. Holmgren, J. M. Sanchez-Ruiz, J. M. Fernandez, Nature 2007, 450, 124.
15. S. Lange, E. Ehler, M. Gautel, Trends Cell Biol. 2006, 16, 11.
16. S. Lange, F. Xiang, A. Yakovenko, A. Vihola, P. Hackman, E. Rostkova, J. Kristensen, B. Brandmeier, G. Franzen, B. Hedberg, L. G. Gunnarsson, S. M. Hughes, S. Marchand, T. Sejersen, I. Richard, L. Edstrom, E. Ehler, B. Udd, M. Gautel, Science 2005, 308, 1599.
17. E. M. Puchner, A. Alexandrovich, A. L. Kho, U. Hensen, L. V. Schafer, B. Brandmeier, F. Grater, H. Grubmuller, H. E. Gaub, M. Gautel, Proc. Natl. Acad. Sci. USA 2008, 105, 13385.
18. L. Tskhovrebova, J. Trinick, Curr. Biol. 2008, 18, R1141.
19. E. M. Puchner, G. Franzen, M. Gautel, H. E. Gaub, Biophys. J. 2008, 95, 426.
20. V. Vogel, M. P. Sheetz, Curr. Opin. Cell Biol. 2009, 21, 38.
21. C. P. Johnson, H. Y. Tang, C. Carag, D.W. Speicher, D.E. Discher, Science 2007, 317, 663.
22. A. del Rio, R. Perez-Jimenez, R. Liu, P. Roca-Cusachs, J. M. Fernandez, M. P. Sheetz, Science 2009, 323, 638.
23. W. Thomas, Annu. Rev. Biomed. Eng. 2008, 10, 39.
24. A. D. Mehta, R. S. Rock, M. Rief, J. A. Spudich, M. S. Mooseker, R. E. Cheney, Nature 1999, 400, 590.
25. M. Good, G. Tang, J. Singleton, A. Remenyi, W. A. Lim, Cell 2009, 136, 1085.
26. N. A. Sallee, G. M. Rivera, J. E. Dueber, D. Vasilescu, R. D. Mullins, B. J. Mayer, W. A. Lim, Nature 2008, 454, 1005.
27. S. W. Stahl, E. M. Puchner, H. E. Gaub, Rev. Sci. Instrum. 2009, 80, 073702.
28. H. Gumpp, S. W. Stahl, M. Strackharn, E. M. Puchner, H. E. Gaub, Rev. Sci. Instrum. 2009, 80, 063704.