Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-speed counter-current chromatography

Journal of Separation Science

Volumn 33, Issue 2, 2010, Pages 277-284

  Gao, Xiang ^a   Zhuang, Rongqiang ^a   Guo, Jiannan ^a   Bao, Jian ^a   Fang, Meijuan ^a   Liu, Yan ^a   Xu, Pengxiang ^a   Zhao, Yufen ^a,b  

^a XIAMEN UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Brefeldin A; ESI MS; High speed counter current chromatography; Macrolide antibiotics; Preparative chromatography

Indexed keywords

BIOACTIVE COMPOUNDS; CHEMICAL NATURE; CRUDE EXTRACT; ETHYL ACETATES; FERMENTATION BROTHS; HIGH PURITY; HIGH-SPEED COUNTER CURRENT CHROMATOGRAPHY; ISOLATED COMPOUNDS; ISOLATION AND PURIFICATION; MACROCYCLICS; MACROLIDE ANTIBIOTICS; PARTITION COEFFICIENT; PEAK FRACTION; PREPARATIVE CHROMATOGRAPHY; PREPARATIVE SEPARATION; SOLVENT SYSTEM; TARGET COMPOUND; TWO STEP METHOD;

CHEMICAL COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ESTERS; PURIFICATION; SPEED; X RAY CRYSTALLOGRAPHY;

ANTIBIOTICS;

7' O ACETYLBREFELDIN A; 7' O FORMYLBREFELDIN A; ACETIC ACID ETHYL ESTER; BREFELDIN A; HEXANE; METHANOL; UNCLASSIFIED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PENICILLIUM; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ACETATES; BREFELDIN A; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUNTERCURRENT DISTRIBUTION; CRYSTALLOGRAPHY, X-RAY; CULTURE MEDIA, CONDITIONED; FERMENTATION; MACROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PENICILLIUM; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

PENICILLIUM;

EID: 76149137291     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900630     Document Type: Article

References (31)

1. Newman, D. J., Cragg, G. M., J. Nat. Prod. 2007, 70, 461-477.
2. Singleton, V. L., Bohonos, N., Ullstrup, A. J., Nature 1958, 181, 1072-1073.
3. Fox, B. M., Vroman, J. A., Fanwick, P. E., Cushman, M., J. Med. Chem. 2001, 44, 3915-3924.
4. Chardin, P., McCormick, F., Cell 1999, 97, 153-155.
5. Mossessova, E., Corpina, R. A., Goldberg, J., Mol. Cell 2003, 12, 1403-1411.
6. Renault, L., Guibert, B., Cherfils, J., Nature 2003, 426, 525-530.
7. Nojiri, H., Manya, H., Isono, H., Nojima, S., FEBS Lett. 1999, 453, 140-144.
8. Corey, E. J., Nicolaou, K. C., Melvin, L. S., Jr., J. Am. Chem. Soc. 1975, 97, 653-654.
9. Trost, B. M., Crawley, M. L., J. Am. Chem. Soc. 2002, 124, 9328-9329.
10. Lin, W. M., Zercher, C. K., J. Org. Chem. 2007, 12, 4390-4395.
11. Wu, Y. K., Gao, J., Org. Lett. 2008, 10, 1533-1536.
12. Zhu, J. W., Nagasawa, H., Nagura, F., Mohamad, S. B., Uto, Y., Ohkura, K., Hori, H., Bioor. Med. Chem. 2000, 8, 455-463.
13. Anadu, N. O., Davisson, V. J., Cushman, M., J. Med. Chem. 2006, 49, 3897-3905.
14. Peddibhotla, S., Dang, Y. J., Liu, J. O., Romo, D., J. Am. Chem. Soc. 2007, 129, 12222-12231.
15. Kim, H. L., Cochevar, J., Gen. Pharmac. 1995, 26, 363-368.
16. Wang, J. F., Huang, Y. J., Fang, M. J., Zhang, Y. J., Zheng, Z. H., Zhao, Y. F., Su, W. J., FEMS Immunol. Med. Microbiol. 2002, 34, 51-57.
17. Ito, Y., Sep. Purif. Rev. 2005, 34, 131-154.
18. Ito, Y., J. Chromatogr. 1981, 214, 122-125.
19. Ito, Y., CRC Crit. Rev. Anal. Chem. 1986, 17, 65-143.
20. He, S., Lu, Y. B., Jiang, L. Y., Wu, B., Zhang, F. Y., Pan, Y. J., J. Sep. Sci. 2009, 32, 2339-2345.
21. Zhao, C. X., He, C. H., J. Sep. Sci. 2006, 29, 1630-1636.
22. Berthod, A., Ruiz-Angel, M. J., Carda-Broch, S. C., J. Chromatogr. A 2009, 1216, 4206-4217.
23. Oka, H., Ikai, Y., Hayakawa, J., Harada, K., Suzuki, M., Shimizu, A., Hayashi, T. et al., J. Chromatogr. A 1996, 723, 61-68.
24. Dobson, G., Christie, W. W., Nikolova-Damyanova, B., J. Chromatogr. B 1995, 671, 197-222.
25. Shi, S., Huang, K., Zhang, Y., Zhao, Y., Du, Q., J. Chromatogr. B 2007, 859, 119-124.
26. Oka, H., Ikai, Y., Harada, K., Suzuki, M., Ito, Y., J. Chromatogr. A 2000, 903, 93-98.
27. Fang, M. J., Fang, H., Huang, Y. J., Zhao, Y. F., Tetrahedron Lett. 2005, 46, 2147-2148.
28. Oka, F., Oka, H., Ito, Y., J. Chromatogr. 1991, 538, 99-108.
29. Han, Q. B., Wong, L., Yang, N. Y., Song, J. Z., Qiao, C. F., Yiu, H., Ito, Y., Xu, H. X., J. Sep. Sci. 2008, 31, 1189-1194.
30. Weber, H. P., Hauser, D., Sigg, H. P., Helv. Chim. Acta 1971, 54, 2763-2766.
31. Glaser, R., Shiftan, D., Froimowitz, M., Magn. Reson. Chem. 2000, 38, 274-280.