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Volumn 4, Issue 3, 2009, Pages 222-233

Microbubbles as drug delivery systems in cerebrovascular diseases

Author keywords

Contrast agent; Drug delivery; Gene therapy; Microbubbles; Molecular imaging; Site targeted therapy; Ultrasonography

Indexed keywords

ALBUMIN; ALBUNEX; CONTRAST MEDIUM; ECHO CONTRAST MEDIUM; FIBRINOLYTIC AGENT; FLUOROCARBON; MRX 815; PERFLEXANE; PERFLUTREN; PHOSPHOLIPID; PLACEBO; POLYMER; SHU 508; SONOVUE; SULFUR HEXAFLUORIDE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE;

EID: 76149098934     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489009789152221     Document Type: Review
Times cited : (2)

References (72)
  • 1
    • 0021365746 scopus 로고
    • Two-dimensional contrast echocardiography. I. in vitro Development and quantitative analysis of echo contrast agents
    • Feinstein SB, Ten Cate FJ, Zwehl W. Two-dimensional contrast echocardiography. I. in vitro Development and quantitative analysis of echo contrast agents. J Am Coll Cardiol 1984; 3(1): 14-20.
    • (1984) J Am Coll Cardiol , vol.3 , Issue.1 , pp. 14-20
    • Feinstein, S.B.1    Ten Cate, F.J.2    Zwehl, W.3
  • 2
    • 3242697895 scopus 로고    scopus 로고
    • The powerful microbubble: From bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond
    • Feinstein SB. The powerful microbubble: From bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. Am J Physiol Heart Circ Physiol 2004; 287(2): H450-H457.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , Issue.2
    • Feinstein, S.B.1
  • 3
    • 33745685392 scopus 로고    scopus 로고
    • Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization
    • Feinstein SB. Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization. J Am Coll Cardiol 2006; 48(2): 236-243.
    • (2006) J Am Coll Cardiol , vol.48 , Issue.2 , pp. 236-243
    • Feinstein, S.B.1
  • 4
    • 0036363549 scopus 로고    scopus 로고
    • Effects of the ultrasound contrast-enhancing agent Levovist on the detection of intracranial arteries and stenoses in Chinese by transcranial Doppler ultrasound
    • Hansberg T, Wong KS, Droste DW, Ringelstein EB, Kay R. Effects of the ultrasound contrast-enhancing agent Levovist on the detection of intracranial arteries and stenoses in Chinese by transcranial Doppler ultrasound. Cerebrovasc Dis 2002; 14(2): 105-108.
    • (2002) Cerebrovasc Dis , vol.14 , Issue.2 , pp. 105-108
    • Hansberg, T.1    Wong, K.S.2    Droste, D.W.3    Ringelstein, E.B.4    Kay, R.5
  • 5
    • 1642376011 scopus 로고    scopus 로고
    • CLOTBUST Investigators. CLOTBUST: Design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke
    • Alexandrov AV, Wojner AW, Grotta JC. CLOTBUST Investigators. CLOTBUST: Design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke. J Neuroimaging 2004; 14(2): 108-112.
    • (2004) J Neuroimaging , vol.14 , Issue.2 , pp. 108-112
    • Alexandrov, A.V.1    Wojner, A.W.2    Grotta, J.C.3
  • 6
    • 1642279961 scopus 로고    scopus 로고
    • CLOTBUST Investigators. Ultrasound-enhanced thrombolysis for acute ischemic stroke: Phase I. Findings of the CLOTBUST trial
    • Alexandrov AV, Demchuk AM, Burgin WS, Robinson DJ, Grotta JC. CLOTBUST Investigators. Ultrasound-enhanced thrombolysis for acute ischemic stroke: Phase I. Findings of the CLOTBUST trial. J Neuroimaging 2004; 14(2): 113-117.
    • (2004) J Neuroimaging , vol.14 , Issue.2 , pp. 113-117
    • Alexandrov, A.V.1    Demchuk, A.M.2    Burgin, W.S.3    Robinson, D.J.4    Grotta, J.C.5
  • 7
    • 33751176083 scopus 로고    scopus 로고
    • Ultrasound contrast agents: An overview
    • Cosgrove D. Ultrasound contrast agents: An overview. Eur J Radiol 2006; 60(3): 324-330.
    • (2006) Eur J Radiol , vol.60 , Issue.3 , pp. 324-330
    • Cosgrove, D.1
  • 8
    • 36049011910 scopus 로고    scopus 로고
    • Ultrasound molecular imaging with targeted microbubble contrast agents
    • Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents. J Nucl Cardiol 2007; 14: 876-884.
    • (2007) J Nucl Cardiol , vol.14 , pp. 876-884
    • Klibanov, A.L.1
  • 9
    • 0032809558 scopus 로고    scopus 로고
    • Pulmonary transit of sonicated albumin microbubbles during controlled mechanical ventilation: A transthoracic echocardiographic study
    • Bilotta F, Fiorani L, Lendaro E, et al. Pulmonary transit of sonicated albumin microbubbles during controlled mechanical ventilation: A transthoracic echocardiographic study. Anesth Analg 1999; 89(2): 273-277.
    • (1999) Anesth Analg , vol.89 , Issue.2 , pp. 273-277
    • Bilotta, F.1    Fiorani, L.2    Lendaro, E.3
  • 11
    • 0036176557 scopus 로고    scopus 로고
    • Ultrasonic contrast agents: Safety considerations reviewed
    • Te Haar GR. Ultrasonic contrast agents: Safety considerations reviewed. Eur J Radiol 2002; 41(3): 217-221;
    • (2002) Eur J Radiol , vol.41 , Issue.3 , pp. 217-221
    • Te Haar, G.R.1
  • 12
    • 33746457788 scopus 로고    scopus 로고
    • Liu Y. Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery. J Control Release 2006; 114: 89-99
    • Liu Y. Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery. J Control Release 2006; 114: 89-99.
  • 15
    • 44249105593 scopus 로고    scopus 로고
    • Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008; 60: 1153-1166.
    • Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008; 60: 1153-1166.
  • 16
  • 17
    • 0024998361 scopus 로고
    • Safety and efficacy of a new transpulmonary ultrasound contrast agent: Initial multicenter clinical results
    • Feinstein SB, Cheirif J, Ten Cate FJ, et al. Safety and efficacy of a new transpulmonary ultrasound contrast agent: Initial multicenter clinical results. J Am Coll Cardiol 1990; 16(2): 316-324.
    • (1990) J Am Coll Cardiol , vol.16 , Issue.2 , pp. 316-324
    • Feinstein, S.B.1    Cheirif, J.2    Ten Cate, F.J.3
  • 19
    • 0024351314 scopus 로고
    • Albunex: A safe and effective commercially produced agent for myocardial contrast echocardiography
    • Keller MW, Glasheen W, Kaul S. Albunex: A safe and effective commercially produced agent for myocardial contrast echocardiography. J Am Soc Echocardiogr 1989; 2(1): 48-52.
    • (1989) J Am Soc Echocardiogr , vol.2 , Issue.1 , pp. 48-52
    • Keller, M.W.1    Glasheen, W.2    Kaul, S.3
  • 20
    • 0030470597 scopus 로고    scopus 로고
    • Quantitative measurements of second harmonic Doppler using ultrasound contrast agents
    • Chang PH, Shung KK, Levene HB. Quantitative measurements of second harmonic Doppler using ultrasound contrast agents. Ultrasound Med Biol 1996; 22(9): 1205-1214.
    • (1996) Ultrasound Med Biol , vol.22 , Issue.9 , pp. 1205-1214
    • Chang, P.H.1    Shung, K.K.2    Levene, H.B.3
  • 21
    • 0024368996 scopus 로고
    • Left heart opacification with peripheral venous injection of a new saccharide echo contrast agent in dogs
    • Smith MD, Elion JL, McClure RR, Kwan OL, DeMaria AN. Left heart opacification with peripheral venous injection of a new saccharide echo contrast agent in dogs. J Am Coll Cardiol 1989; 13(7): 1622-1628.
    • (1989) J Am Coll Cardiol , vol.13 , Issue.7 , pp. 1622-1628
    • Smith, M.D.1    Elion, J.L.2    McClure, R.R.3    Kwan, O.L.4    DeMaria, A.N.5
  • 22
    • 0034015765 scopus 로고    scopus 로고
    • Infusion versus bolus contrast echocardiography: A multicenter, open-label, crossover trial
    • Weissman NJ, Cohen MC, Hack TC, Gillam LD, Cohen JL, Kitzman DW. Infusion versus bolus contrast echocardiography: A multicenter, open-label, crossover trial. Am Heart J 2000; 139(3): 399-404.
    • (2000) Am Heart J , vol.139 , Issue.3 , pp. 399-404
    • Weissman, N.J.1    Cohen, M.C.2    Hack, T.C.3    Gillam, L.D.4    Cohen, J.L.5    Kitzman, D.W.6
  • 23
    • 0032040264 scopus 로고    scopus 로고
    • Clinical experience with AF0150 (Imagent US), a new ultrasound contrast agent
    • discussion S72-S74
    • Pelura TJ. Clinical experience with AF0150 (Imagent US), a new ultrasound contrast agent. Acad Radiol 1998; 5 (Suppl 1): S69-S71; discussion S72-S74.
    • (1998) Acad Radiol , vol.5 , Issue.SUPPL. 1
    • Pelura, T.J.1
  • 24
    • 0001580321 scopus 로고    scopus 로고
    • Schneider M. SonoVue, a new ultrasound contrast agent. Eur Radiol 1999; 9 (Suppl 3): S347-348.
    • Schneider M. SonoVue, a new ultrasound contrast agent. Eur Radiol 1999; 9 (Suppl 3): S347-348.
  • 25
    • 0025142480 scopus 로고
    • On the application of ultrasonic contrast agents for blood flowmetry and assessment of cardiac perfusion
    • Bleeker H, Shung K, Barnhart J. On the application of ultrasonic contrast agents for blood flowmetry and assessment of cardiac perfusion. J Ultrasound Med 1990; 9: 461-471.
    • (1990) J Ultrasound Med , vol.9 , pp. 461-471
    • Bleeker, H.1    Shung, K.2    Barnhart, J.3
  • 26
    • 0026544982 scopus 로고
    • Transesophageal dipyridamole echocardiography for diagnosis of coronary artery disease
    • Agati L, Renzi M, Sciomer S. Transesophageal dipyridamole echocardiography for diagnosis of coronary artery disease. J Am Coll Cardiol 1992; 19: 765-770.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 765-770
    • Agati, L.1    Renzi, M.2    Sciomer, S.3
  • 27
    • 0025144621 scopus 로고
    • Dagianti A, Feigenbaum H, Eds. Excerpta Medica: Amsterdam
    • Voci P, Bilotta F, Reale A. Echocardiography. In: Dagianti A, Feigenbaum H, Eds. Excerpta Medica: Amsterdam 1990: 255-260.
    • (1990) Echocardiography , pp. 255-260
    • Voci, P.1    Bilotta, F.2    Reale, A.3
  • 28
    • 0026068092 scopus 로고
    • in vitro Development and clinical applications of sonicated echocotrast agents
    • Voci P, Bilotta F, Scibilia G. in vitro Development and clinical applications of sonicated echocotrast agents. Am J Card Image 1991; 5: 192-199.
    • (1991) Am J Card Image , vol.5 , pp. 192-199
    • Voci, P.1    Bilotta, F.2    Scibilia, G.3
  • 29
    • 76149125617 scopus 로고    scopus 로고
    • Sutton, A.D., Johnson R.A., Senior, P.J., Heath, D.: WO9218164 (1992).
    • Sutton, A.D., Johnson R.A., Senior, P.J., Heath, D.: WO9218164 (1992).
  • 30
    • 76149089366 scopus 로고    scopus 로고
    • Schneider, T., Roessling, G., Sachse, A.: WO9408626 (1994).
    • Schneider, T., Roessling, G., Sachse, A.: WO9408626 (1994).
  • 33
    • 0021337734 scopus 로고
    • Myocardial contrast two-dimensional echocardiography: Experimental examination at different coronary flo levels
    • Ten Cate FJ, Drury KJ, Meerbaum S, Noordsy J, Feinstein SB, Shah PM. Myocardial contrast two-dimensional echocardiography: experimental examination at different coronary flo levels. J Am Coll Cardiol 1984; 13: 219-226.
    • (1984) J Am Coll Cardiol , vol.13 , pp. 219-226
    • Ten Cate, F.J.1    Drury, K.J.2    Meerbaum, S.3    Noordsy, J.4    Feinstein, S.B.5    Shah, P.M.6
  • 34
    • 0026642692 scopus 로고
    • Clinical applications of myocardial contrast echocardiography
    • Kaul S. Clinical applications of myocardial contrast echocardiography. Am J Cardiol 1992; 69: 46H-64H.
    • (1992) Am J Cardiol , vol.69
    • Kaul, S.1
  • 35
    • 0028471176 scopus 로고
    • Myocardial contrast enhancement after intravenous injection of sonicated albumin microbubbles: A transesophageal echocardiography dipyridamole study
    • Voci P, Bilotta F, Merialdo P, Agati L. Myocardial contrast enhancement after intravenous injection of sonicated albumin microbubbles: A transesophageal echocardiography dipyridamole study. J Am Soc Echocardiogr 1994; 7(4): 337-346.
    • (1994) J Am Soc Echocardiogr , vol.7 , Issue.4 , pp. 337-346
    • Voci, P.1    Bilotta, F.2    Merialdo, P.3    Agati, L.4
  • 36
    • 0025612337 scopus 로고
    • Intravenous contrast echocardiography with the use of sonicated albumin in humans: Systolic disappearance of left ventricular contrast after transpulmonary transmission
    • Shapiro JR, Reisner SA, Lichtemberg GS, Meltzer RS. Intravenous contrast echocardiography with the use of sonicated albumin in humans: Systolic disappearance of left ventricular contrast after transpulmonary transmission. J Am Coll Cardiol 1990; 16: 1603-1607.
    • (1990) J Am Coll Cardiol , vol.16 , pp. 1603-1607
    • Shapiro, J.R.1    Reisner, S.A.2    Lichtemberg, G.S.3    Meltzer, R.S.4
  • 37
    • 0018305485 scopus 로고
    • Preparation of hollow spherical particles
    • Farnard JR, Puddington IE. Preparation of hollow spherical particles. Powder Technol 1979; 22: 11-16.
    • (1979) Powder Technol , vol.22 , pp. 11-16
    • Farnard, J.R.1    Puddington, I.E.2
  • 38
    • 0025789981 scopus 로고
    • A new ultrasound contrast agent based on biodegradable polymeric microballons
    • Schneider M, Bussat P, Barrau MB, et al. A new ultrasound contrast agent based on biodegradable polymeric microballons. Invest Radiol 1991; 26: 190-191
    • (1991) Invest Radiol , vol.26 , pp. 190-191
    • Schneider, M.1    Bussat, P.2    Barrau, M.B.3
  • 39
    • 0026544026 scopus 로고
    • Polymeric microballons as ultrasound contrast agents physical and ultrasonic properties compared with sonicated albumin
    • Schneider M, Bussat P, Barrau MB, et al. Polymeric microballons as ultrasound contrast agents physical and ultrasonic properties compared with sonicated albumin. Invest Radiol 1992; 27: 134-139.
    • (1992) Invest Radiol , vol.27 , pp. 134-139
    • Schneider, M.1    Bussat, P.2    Barrau, M.B.3
  • 41
    • 16244398528 scopus 로고    scopus 로고
    • Myocardial contrast echocardiography
    • Lepper W, Belcik T, Wei K, et al. Myocardial contrast echocardiography. Circulation 2004; 109: 3132-3135.
    • (2004) Circulation , vol.109 , pp. 3132-3135
    • Lepper, W.1    Belcik, T.2    Wei, K.3
  • 43
    • 0030976624 scopus 로고    scopus 로고
    • Influence of formulation variables on the in vitro release of albumin from biodegradable microparticulate systems
    • Igartua M, Hernandez RM, Esquisabel A, et al. Influence of formulation variables on the in vitro release of albumin from biodegradable microparticulate systems. J Microencapsul 1997; 14: 349-356.
    • (1997) J Microencapsul , vol.14 , pp. 349-356
    • Igartua, M.1    Hernandez, R.M.2    Esquisabel, A.3
  • 47
    • 0038445582 scopus 로고    scopus 로고
    • Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J Control Release 2003; 90: 261-280
    • Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J Control Release 2003; 90: 261-280.
  • 48
    • 11144327114 scopus 로고    scopus 로고
    • Sensitive particle acoustic quantification (SPAQ): A new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations
    • Reinhardt M, Hauff P, Briel A, et al. Sensitive particle acoustic quantification (SPAQ): A new ultrasound-based approach for the quantification of ultrasound contrast media in high concentrations. Invest Radiol 2005; 40: 2-7.
    • (2005) Invest Radiol , vol.40 , pp. 2-7
    • Reinhardt, M.1    Hauff, P.2    Briel, A.3
  • 49
    • 33846233142 scopus 로고    scopus 로고
    • Experimental investigations of nonlinearities and destruction mechanisms for an experimental phospholipid-based ultrasound contrast agent
    • Casciaro S, Palmizio ER, Conversano F, Demitri C, Distante A. Experimental investigations of nonlinearities and destruction mechanisms for an experimental phospholipid-based ultrasound contrast agent. Invest Radiol 2007; 42: 95-104.
    • (2007) Invest Radiol , vol.42 , pp. 95-104
    • Casciaro, S.1    Palmizio, E.R.2    Conversano, F.3    Demitri, C.4    Distante, A.5
  • 52
    • 0018136191 scopus 로고
    • Removal of intravascular thrombi by means of ultrasonics. Experimental study with a new method and its clinical use
    • Trubestein G. Removal of intravascular thrombi by means of ultrasonics. Experimental study with a new method and its clinical use. Fortschr Med 1978; 96: 755-760.
    • (1978) Fortschr Med , vol.96 , pp. 755-760
    • Trubestein, G.1
  • 53
    • 0032471036 scopus 로고    scopus 로고
    • Binding and lysing of blood clots using MRX-408
    • Wu Y, Unger EC, McCreery TP, et al. Binding and lysing of blood clots using MRX-408. Invest Radiol 1998; 33(12): 880-885.
    • (1998) Invest Radiol , vol.33 , Issue.12 , pp. 880-885
    • Wu, Y.1    Unger, E.C.2    McCreery, T.P.3
  • 54
    • 0029154850 scopus 로고
    • Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis
    • Tachibana K, Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 1995; 92: 1148-1150.
    • (1995) Circulation , vol.92 , pp. 1148-1150
    • Tachibana, K.1    Tachibana, S.2
  • 55
    • 0029807006 scopus 로고    scopus 로고
    • Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles
    • Porter TR, LeVeen RF, Fox R, Kricsfeld A, Xie F. Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. Am Heart J 1996; 132: 964-968.
    • (1996) Am Heart J , vol.132 , pp. 964-968
    • Porter, T.R.1    LeVeen, R.F.2    Fox, R.3    Kricsfeld, A.4    Xie, F.5
  • 56
    • 33644851343 scopus 로고    scopus 로고
    • Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator
    • Molina CA, Ribo M, Rubiera M, et al. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 2006; 37: 425-429.
    • (2006) Stroke , vol.37 , pp. 425-429
    • Molina, C.A.1    Ribo, M.2    Rubiera, M.3
  • 57
    • 44249105593 scopus 로고    scopus 로고
    • Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008; 60: 1153-1166.
    • Hernot S, Klibanov AL. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008; 60: 1153-1166.
  • 58
    • 0037766220 scopus 로고    scopus 로고
    • Effect of ultrasound on thrombolysis of middle cerebral artery occlusion
    • Eggers J, Koch B, Meyer K, et al. Effect of ultrasound on thrombolysis of middle cerebral artery occlusion. Ann Neurol 2003; 53: 797-800.
    • (2003) Ann Neurol , vol.53 , pp. 797-800
    • Eggers, J.1    Koch, B.2    Meyer, K.3
  • 59
    • 22044441701 scopus 로고    scopus 로고
    • Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: Increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: Results of a phase II clinical trial
    • Daffertshofer M, Gass A, Ringleb P, et al. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: Increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: Results of a phase II clinical trial. Stroke 2005; 36(7): 1441-1446.
    • (2005) Stroke , vol.36 , Issue.7 , pp. 1441-1446
    • Daffertshofer, M.1    Gass, A.2    Ringleb, P.3
  • 61
    • 4444278241 scopus 로고    scopus 로고
    • Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction
    • Tsutsui JM, Xie F, Cano M, et al. Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction. J Am Coll Cardiol 2004; 44(5): 1036-1046.
    • (2004) J Am Coll Cardiol , vol.44 , Issue.5 , pp. 1036-1046
    • Tsutsui, J.M.1    Xie, F.2    Cano, M.3
  • 62
    • 34548406555 scopus 로고    scopus 로고
    • Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis
    • Marsh JN, Senpan A, Hu G, et al. Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis. Nanomed 2007; 2(4): 533-543.
    • (2007) Nanomed , vol.2 , Issue.4 , pp. 533-543
    • Marsh, J.N.1    Senpan, A.2    Hu, G.3
  • 64
    • 0037244070 scopus 로고    scopus 로고
    • Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations
    • Banks WA. Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations. Curr Pharm Des 2003; 9: 801-809.
    • (2003) Curr Pharm Des , vol.9 , pp. 801-809
    • Banks, W.A.1
  • 65
    • 2542475986 scopus 로고    scopus 로고
    • Clearing amyloid through the blood-brain barrier
    • Zlokovic BV. Clearing amyloid through the blood-brain barrier. J Neurochem 2004; 89: 807-811.
    • (2004) J Neurochem , vol.89 , pp. 807-811
    • Zlokovic, B.V.1
  • 66
    • 84942852165 scopus 로고    scopus 로고
    • Pan W, Kastin AJ. In: Sharma HS, Westman J, Eds. Blood-spinal cord and brain barriers in health and disease. Chapter 20: Transport of cytokines and neurotrophins across the blood-brain barrier and their regulation after spinal cord injury. Elsevier, Amsterdam: The Netherlands 2004: 395-407.
    • Pan W, Kastin AJ. In: Sharma HS, Westman J, Eds. Blood-spinal cord and brain barriers in health and disease. Chapter 20: Transport of cytokines and neurotrophins across the blood-brain barrier and their regulation after spinal cord injury. Elsevier, Amsterdam: The Netherlands 2004: 395-407.
  • 68
    • 1842534859 scopus 로고    scopus 로고
    • Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment
    • Ng KY, Cho CW, Henthorn TK, Tanguay RL. Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment. J Pharm Sci 2004; 93(4): 896-907.
    • (2004) J Pharm Sci , vol.93 , Issue.4 , pp. 896-907
    • Ng, K.Y.1    Cho, C.W.2    Henthorn, T.K.3    Tanguay, R.L.4
  • 69
    • 33745137108 scopus 로고    scopus 로고
    • Blood-brain barrier disruption by low-frequency ultrasound
    • Reinhard M, Hetzel A, Krüger S, et al. Blood-brain barrier disruption by low-frequency ultrasound. Stroke 2006; 37(6): 1546-1548.
    • (2006) Stroke , vol.37 , Issue.6 , pp. 1546-1548
    • Reinhard, M.1    Hetzel, A.2    Krüger, S.3
  • 70
    • 0034876083 scopus 로고    scopus 로고
    • Noninvasive MR Imaging-guided focal opening of the blood-brain barrier in rabbits
    • Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Noninvasive MR Imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 2001; 220(3): 640-646.
    • (2001) Radiology , vol.220 , Issue.3 , pp. 640-646
    • Hynynen, K.1    McDannold, N.2    Vykhodtseva, N.3    Jolesz, F.A.4
  • 71
    • 55749097592 scopus 로고    scopus 로고
    • Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes
    • Kopechek JA, Abruzzo TM, Wang B, et al. Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. J Ultrasound Med 2008; 27(11): 1597-1606.
    • (2008) J Ultrasound Med , vol.27 , Issue.11 , pp. 1597-1606
    • Kopechek, J.A.1    Abruzzo, T.M.2    Wang, B.3


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