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Further studies can be found in the Supporting Information
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Further studies can be found in the Supporting Information.
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Reaction of 4 with 2a under the optimized conditions from Table 1 did not afford compound 3a, ruling out a gold-catalyzed Sonogashira reaction mechanism; see: González-Arellano, C.; Abad, A.; Corma, A.; García, H.; Iglesias, M.; Sánchez, F. Angew. Chem., Int. Ed. 2007, 46, 1536.
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Reaction of 4 with 2a under the optimized conditions from Table 1 did not afford compound 3a, ruling out a gold-catalyzed Sonogashira reaction mechanism; see: González-Arellano, C.; Abad, A.; Corma, A.; García, H.; Iglesias, M.; Sánchez, F. Angew. Chem., Int. Ed. 2007, 46, 1536.
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A Au-catalyzed ethynylation of indoles and pyrrols appeared during the preparation of this manuscript; see
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sp2-H activation would be involved, primary KIE should have been observed: Gretz, E.; Oliver, T. F.; Sen, A. J. Am. Chem. Soc. 1987, 109, 8109.
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