CLM1 of fusarium graminearum encodes a longiborneol synthase required for culmorin production

Applied and Environmental Microbiology

Volumn 76, Issue 1, 2010, Pages 136-141

  McCormick, S P ^a   Alexander, N J ^a   Harris, L J ^b  

^a NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

^b OTTAWA RESEARCH AND DEVELOPMENT CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC GENE; BUTENOLIDES; CEREAL CROP; CYCLASES; F. GRAMINEARUM; FUNGAL PATHOGEN; FUSARIUM GRAMINEARUM; GENE DISRUPTIONS; RING STRUCTURES; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; SYNTHASES; TRICHOTHECENES; ZEARALENONE;

BIOCHEMISTRY; GENE EXPRESSION; OLEFINS; TOXIC MATERIALS; YEAST;

BIOSYNTHESIS;

CULMORIN; FUNGAL DNA; LIGASE; LONGIBORNEOL; SESQUITERPENE;

CEREAL; DATABASE; ENZYME ACTIVITY; GENE EXPRESSION; PATHOTYPE; TOXIN; YEAST;

ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; ENZYMOLOGY; EXPRESSED SEQUENCE TAG; FUSARIUM; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETIC DATABASE; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SACCHAROMYCES CEREVISIAE;

BIOSYNTHETIC PATHWAYS; CLONING, MOLECULAR; DATABASES, GENETIC; DNA, FUNGAL; EXPRESSED SEQUENCE TAGS; FUSARIUM; GENE DELETION; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; LIGASES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, INSERTIONAL; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS, DNA; SESQUITERPENES;

GIBBERELLA ZEAE; HORDEUM; SACCHAROMYCES CEREVISIAE; TRITICUM AESTIVUM; ZEA MAYS;

EID: 76149085865     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02017-09     Document Type: Article

References (38)

1. Alexander, N. J, S. P. McCormick, and T. M. Hohn. 1999. TRI12, a trichothecene efflux pump from. Fusarium sporotrichioides: gene isolation and expression in yeast. MoI. Gen. Genet. 261:977-984.
2. Barton, D. H. R., and N. H. Werstiuk. 1968. Sesquiterpenoids. Part XIV. The constitution and stereochemistry of culmorin. J. Chem. Soc. C 1968:148-155.
3. Bowden, R. L., and J. F. Leslie. 1992. Nitrate-nonutilizing mutants of Gibberella zeae (Fusarium graminearum) and their use in determining vegetative compatibility. Exp. Mycol. 16:308-315.
4. Cane, D. E., and N. Ke. 2000. Epicubenol synthase. Origin of the oxygen, atom of a bacterial sesquiterpene alcohol. Bioorg. Med. Chem. Lett. 10:105107.
5. Desjardins, A. E., R. H. Proctor, G. Bai, S. P. McCormick, G. Shatter, G. Beuchley, and T. M. Hohn. 1996. Reduced virulence of trichothecene-nonproducing mutants of Gibberella zeae in wheat field tests. MoI. Plant-Microbe Interact. 9:775-781.
6. Dowd, P. F. 1989. Toxicity and interactions of some Fusarium graminearum metabolites to caterpillars. Mycologia. 81:646-650.
7. Ehrlich, K. C., B. G. Montalbano, J. W. Cary, and P. J. Cotty. 2002. Promoter elements in the aflatoxin pathway polyketide synthase gene. Biochim. Biophys. Acta 1576:171-175.
8. Ghebremeskel, M., and W. Langsetlt. 2001. The occurrence of culmorin and hydroxy-culmorins in cereals. Mycopathologia 152:103-108.
9. Güldener, U., K.-Y. Seong, J. Boddu, S. Cho, F. Trail, J. R. Xu, G. Adam, H. W. Mewes, G. J. Muehlbauer, and H. C. Kistler. 2006. Development of a Fusarium graminearum Affymetrix GeneChip for profiling fungal gene expression in. vitro and in. planta. Fungal. Genet. Biol. 43:316-325.
10. Hanson, J. R., and R. Nyfeler. 1976. Studies in terpenoid biosynthesis. Part 18. Biosynthesis of culmorin. J. Chem. Soc. Perkin I 1976:2471-2475.
11. Harris, L. J., N. J. Alexander, A. Saparno, B. Blackwell, S. P. McCormick, A. E. Desjardins, L. S. Robert, L. S. N. Tinker, J. Hattori, J. C. Piché, J. P. Schernthaner, R. Watson, and T. Ouellet. 2007. A novel gene cluster in Fusarium graminearum contains a. gene that contributes to butenolide synthesis. Fungal Genet. Biol. 44:293-306.
12. Hohn, T. M., and P. D. Beremand. 1989. Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. Gene 79:131-138.
13. Hohn, T. M., R. Krishna, and R. H. Proctor. 1999. Characterization of a transcriptional activator controlling trichothecene toxin biosynthesis. Fungal Genet. Biol. 26:224-235.
14. Hua, L., and S. P. T. Matsuda. 1999. The molecular cloning of 8-epicedrol synthase from Artemisia annua. Arch. Biochem. Biophys. 369:208-212.
15. Jelén, H. H., C. J. Mirocha, E. Wasowicz, and E. Kaminski. 1995. Production of volatile sesquiterpenes by Fusarium sambucinum strains with different abilities to synthesize trichothecenes. Appl. Environ. Microbiol. 61:38153820.
16. Kasitu, G. C., J. W. ApSimon, B. A. Blackwell, D. A. Fielder, R. Greenhalgh, and J. D. Miller. 1992. Isolation and chracterization of culmorin derivatives produced by Fusarium culmorum CMI 14764. Can. J. Chem. 70:1308-1316.
17. Langseth, W., M. Ghebremeskel, B. Kosiak, P. Kolsaker, and J. D. Miller. 2001. Production of culmorin compounds and other secondary metabolites by Fusarium culmorum and F. graminearum strains isolated from Norwegian cereals. Mycopathologia 152:23-34.
18. Martin, D. M., J. Faldt, and J. Bohlmann. 2004. Functional characterization of nine Norway spruce 77',S genes and evolution of gymnosperm terpene synthases of the TPS-d superfamily. Plant Physiol. 135:1908-1927.
19. McCormick, S. P., and N. J. Alexander. 2002. Fusarium Tri8 encodes a trichothecene C-3 esterase. Appl. Environ. Microbiol. 68:2959-2964.
20. McCormick, S. P., L. J. Harris, N. J. Alexander, T. Ouellet, A. Saparno, S. Allard, and A. E. Desjardins. 2004. Tri1 in Fusarium graminearum encodes a P450 oxygenase. Appl. Environ. Microbiol. 70:2044-2051.
21. Mercke,' P., J. Crock, R. Croteau, and P. E. Brodelius. 1999. Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L. Arch. Biochem. Biophys. 369:213-222.
22. Meyers, S., W. Schauer, E. Balzi, M. Wagner, A. Goffeau, and J. Golin. 1992. Interaction of the pleiotrophic drug resistance genes PDR1 and PDR5. Curr. Genet. 21:431-436.
23. Miller, J. D., and B. A. Blackwell. 1986. Biosynthesis of 3-acetyldeoxynivalenol and other metabolites by Fusarium culmorum HLK 1503. Can. J. Bot. 64:1-5.
24. Miller, J. D., and S. MacKenzie. 2000. Secondary metabolites of Fusarium venenatum strains with deletions in the TriS gene encoding trichodiene synthetase. Mycologia 92:764-771.
25. Pedersen, P. B., and J. D. Miller. 1999. The fungal metabolite culmorin and related compounds. Nat. Toxins 7:305-309.
26. Proctor, R. H., T. M. Hohn, and S. P. McCormick. 1995. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin, biosynthetic gene. MoI. Plant-Microbe Interact. 61:1923-1930.
27. Reid, L. M., and R. I. Hamilton. 1996. Effects of inoculation position, timing, macroconidial concentration, and irrigation on resistance of maize to Fusarium graminearum infection through kernels. Can. J. Plant Pathol. 18:278285.
28. Sakai, M., and T. Yamaskai. 1990. (+)-Juniperol and ( + )-pimaral: attractants for the cerambycid beetle, Monochamus alternatus Hope. J. Chem. Ecol. 16:3383-3391.
29. Savard, M. E., and B. A. Blackwell. 1994. Spectral characteristics of secondary metabolites from Fusarium fungi, p. 59-257. In J. D. Miller and H. L. Trenholm (ed.), Mykotoxins in grain. Compounds other than aflatoxin. Eagan Press, St. Paul, MN.
30. Seong, K-Y., M. Pasquali, X. Zhou, J. Song, K. Hilbrun, S. P. McCormick, Y. Dong, J. R. Xu, and H. C. Kistler. 2009. Global gene regulation by Fusarium transcription factors Tri6 and TrilO reveals adaptations for toxin biosynthesis. MoI. Microbiol. 72:354-367.
31. Stevens, R. R. 1974. Mycology guidebook, p. 703. University of Washington Press, Seattle, WA.
32. Strongman, D. B., J. D. Miller, L Calhoun, J. A. Findlay, and N. J. Whitney. 1987. The biochemical basis for interference competition among some lignicolous marine fungi. Botanica Marina. 30:21-26.
33. Tanaka, A., and T. Tsuge. 2001. Reporter gene analysis of AKT3-1 and AKT3-2 expression, during conidia! germination of the Japanese pear pathotype of Alternaria alternala. .J. Gen. .Plant Pathol. 67:1.5-22.
34. Then Bergh, K., and A. A. Brakhage. 1998. Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of the transcription factor PacC. Appl. Environ. Microbiol. 64:843-849.
35. Tilburn, J., S. Sarkar, D. A. Widdick, E. A. Espeso, M. Orejas, J. Mungroo, M. A. Penalva, and H. N. Arst, Jr. 1995. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J. 14:779-790.
36. Turgeon, B. G., R. C. Garber, and O. C. Yoder. 1987. Development of a fungal transformation system based on selection of sequences with promoter activity. MoI. Cell. Biol. 17:3297-3305.
37. Wang, Y. Z., and J. D. Miller. 1988. Effects of Fusarium graminearum metabolites on wheat tissue in relation to Fusarium head blight resistance. J. Phytopathol. 122:118-125.
38. Wessler, S. R. 1994. Isolation of RNA from Wx and wx endosperms, p. 545-546. In M. Freeling and V. Walbot (ed.), The maize handbook. Springer-Verlag, New York, NY.