Inhibitory effect of paclitaxel on endothelial cell adhesion and migration

Pharmacology

Volumn 85, Issue 3, 2010, Pages 136-145

  Li, Hua ^a   Zhang, Li Jun ^b   Chen, Bai Hua ^c   Zhou, Xuan ^a   Su, Ke ^a   Shi, Wen Tao ^a   Wu, Jun Zhu ^a   Yu, Hong ^a   Wei, Lei ^a  

^a WUHAN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Adhesion; Endothelial cell; Migration; Paclitaxel; Vasodilator stimulated phosphoprotein

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PACLITAXEL; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CARDIOVASCULAR AGENTS; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE; CELL MOVEMENT; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; HUMANS; MICROFILAMENT PROTEINS; PACLITAXEL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 76049127216     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000280587     Document Type: Article

References (28)

1. Schwartz RS, Chronos NA, Virmani R: Preclinical restenosis models and drug-eluting stents: still important, still much to learn. J Am Coll Cardiol 2004;44:1373-1385.
2. Park SJ, Shim WH, Ho DS, Raizner AE, Park SW, Hong MK, Lee CW, Choi D, Jang Y, Lam R, Weissman NJ, Mintz GS: A paclitaxeleluting stent for the prevention of coronary restenosis. N Engl J Med 2003;348:1537-1545.
3. Pollard TD, Borisy GG: Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003;112:453-465.
4. Davis HW, Vanden Berg E, Reid MD, RoyChaudhury P, Edwards JD: Paclitaxel impairs endothelial cell adhesion but not cytokine-induced cellular adhesion molecule expression. Ann Vasc Surg 2005;19:398-406.
5. Giessmann D, Theiss C, Breipohl W, Meller K: Decreased gap junctional communication in neurobiotin microinjected lens epithelial cells after taxol treatment. Anat Embryol (Berl) 2005;209:391-400.
6. Rosenblum MD, Shivers RR: 'Rings' of F-actin form around the nucleus in cultured human MCF7 adenocarcinoma cells upon exposure to both taxol and taxotere. Comp Biochem Physiol C Toxicol Pharmacol 2000;125:121-131.
7. Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB: Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 2002;109:509-521.
8. Reinhard M, Jarchau T, Walter U: Actinbased motility: stop and go with Ena/VASP proteins. Trends Biochem Sci 2001;26:243-249.
9. Gertler FB, Niebuhr K, Reinhard M, Wehland J, Soriano P: Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell 1996;87:227-239.
10. Bear JE, Loureiro JJ, Libova I, Fassler R, Wehland J, Gertler FB: Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 2000;101:717-728.
11. Han G, Fan B, Zhang Y, Zhou X, Wang Y, Dong H, Wei Y, Sun S, Hu M, Zhang J, Wei L: Positive regulation of migration and invasion by vasodilator- stimulated phosphoprotein via Rac1 pathway in human breast cancer cells. Oncol Rep 2008;20:929-939.
12. Zhang Y, Han G, Fan B, Zhou Y, Z hou X, Wei L, Zhang J: Green tea (-)-epigallocatechin-3-gallate down-regulates VASP expression and inhibits breast cancer cell migration and invasion by attenuating Rac1 activity. Eur J Pharmacol 2009;606:172-179.
13. Bae YH, Ding Z, Zou L, Wells A, Gertler F, Roy P: Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. Cell Physiol 2009;219:354-364.
14. Butt E, Abel K, Krieger M, Pa l m D, Hoppe V, Hoppe J, Walter U: cAMP - and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J Biol Chem 1994;269:14509-14517.
15. Howe AK, Juliano RL: Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol 2000;2:593-600.
16. Santos MF, McCormack SA, Guo Z, Okolicany J, Zheng Y, Johnson LR, Tigyi G: Rho proteins play a critical role in cell migration during the early phase of mucosal restitution. J Clin Invest 1997;100:216-225.
17. Harbeck B, Huttelmaier S, Schluter K, Jockusch BM, Illenberger S: Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem 2000;275:30817-30825.
18. Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, Wei L: Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol 2007;563:69-76.
19. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT: Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 1971;93:2325-2327.
20. Rowinsky EK, Eisenhauer EA, Chaudhry V, Arbuck SG, Donehower RC: Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol 1993;20:1-15.
21. Rowinsky EK, Donehower RC: Paclitaxel (taxol). N Engl J Med 1995;332:1004-1014.
22. Hotchkiss KA, Ashton AW, Mahmood R, Russell RG, Sparano JA, Schwartz EL: Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center. Mol Cancer Ther 2002;1:1191-1200.
23. Howe AK, Baldor LC, Hogan BP: Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration. Proc Nat l Acad Sci USA 2005;102:14320-14325.
24. Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG, Gertler FB: Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 2004;42:37-49.
25. Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S: Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow. J Vasc Res 2002;39:465-476.
26. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22.
27. Lamalice L, Houle F, Jourdan G, Huot J: Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38. Oncogene 2004;23:434-445.
28. Wei L, Muller S, Ouyang J, Stoltz JF, Wang X: Changes of vasodilator-stimulated phosphoprotein (VASP) and its phosphorylation in endothelial cells exposed to laminar flow. Clin Hemorheol Microcirc 2003;28:113-120.