Insulin inhibits and oral sucrose increases neointimal growth after arterial injury in rats

Journal of Vascular Research

Volumn 47, Issue 5, 2010, Pages 412-422

  Breen, Danna M ^a   Dhaliwall, Jiwanjeet K ^a   Chan, Kalam K ^a   Guo, June ^a   Lam, Loretta ^a   Bendeck, Michelle P ^a,b   Giacca, Adria ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angioplasty; Glucose; Insulin; Neointima; Proliferation; Sucrose

Indexed keywords

GLUCOSE; INSULIN; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPERINSULINEMIA; IMPLANT; INSULIN SENSITIVITY; INTIMA; MALE; METABOLIC PARAMETERS; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANGIOPLASTY, BALLOON; ANIMALS; CAROTID ARTERY INJURIES; DYSLIPIDEMIAS; FASTING; GLUCOSE; INSULIN; MALE; RATS; SUCROSE; TUNICA INTIMA; TUNICA MEDIA;

EID: 76049103621     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000281581     Document Type: Article

References (31)

1. Groop L, Orho-Melander M: The dysmeta-bolic syndrome. J Intern Med 2001; 250:105-120.
2. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C: Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433-438.
3. Alberti KG, Zimmet P, Shaw J: Metabolic syndrome: a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 2006; 23: 469-480.
4. Grundy SM: Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endo-crinol Metab 2007; 92:399-404.
5. Ferrannini E: Metabolic syndrome: a solution in search of a problem. J Clin Endocrinol Metab 2007; 92: 396-398.
6. Piatti P, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A, Setola E, Lucotti P, Gal-luccio E, Ronchi C, Origgi A, Zavaroni I, Margonato A, Colombo A: Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation 2003; 108:2074-2081.
7. Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM: Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 1998; 97:996-1001.
8. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R: Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation 1996; 93:1809-1817.
9. Kim T, Chan KK, Dhaliwall JK, Huynh N, Suen R, Uchino H, Naigamwalla D, Bendeck MP, Giacca A: Anti-atherogenic effect of in-su lin in vivo. J Vasc Res 2005; 42: 455-462.
10. Ridray S, Ktorza A, Picon L, Capron L: In vivo effect of insulin on the acute prolifera-tive response of the rat aorta to injury. Arte-rioscler Thromb 1992; 12: 633-638.
11. Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al KN, Lam L, De SM, Ghanim H, Dan-dona P, Stewart DJ, Bendeck MP, Giacca A: Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol 2009; 29:1060-1066.
12. Nystrom T, Gonon AT, Sjoholm A, Pernow J: Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regu l Pept 2005; 125: 17 3-17 7.
13. Gardiner SM, March JE, Kemp PA, Bennett T: Mesenteric vasoconstriction and hindquarters vasodilatation accompany the pres-sor actions of exendin-4 in conscious rats. J Pharmacol Exp Ther 20 06; 316: 852-859.
14. Nystrom T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahren B, Sjoholm A: Effects of glu-cagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004; 287:E1209-E1215.
15. Kogire M, Inoue K, Sumi S, Doi R, Yun M, Kaji H, Tobe T: Effects of gastric inhibitory polypeptide and glucagon on portal venous and hepatic arterial flow in conscious dogs. Dig Dis Sci 1992; 37:1666-1670.
16. Foster E, Zhang S, Kahn AM: Insulin stimulates arterial neointima formation in normal rats after balloon injury. Diabetes Obes Metab 2006; 8:348-351.
17. Thorburn AW, Storlien LH, Jenkins AB, Khouri S, Kraegen EW: Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr 1989; 49: 11 5 5-116 3.
18. Wang PY: The reliability of a compressed mixture of insulin and palmitic acid to sustain a reduction in hyperglycemia in rodents. ASAIO Trans 1987; 33: 31 9-3 2 2.
19. McTernan PG, Harte AL, Anderson LA, Green A, Smith SA, Holder JC, Barnett AH, Eggo MC, Kumar S: Insulin and rosiglita-zone regulation of lipolysis and lipogenesis in human adipose tissue in vitro. Diabetes 2002; 51: 14 9 3-14 9 8.
20. Indolfi C, Torella D, Cavuto L, Davalli AM, Coppola C, Esposito G, Carriero MV, Rapac-ciuolo A, Di Lorenzo E, Stabile E, Perrino C, Chieffo A, Pardo F, Chiariello M: Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hy-perinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation 2001; 103: 2980-2986.
21. Pu Q, Chang Y, Zhang C, Cai Y, Hassid A: Chronic insulin treatment suppresses PTP1B function, induces increased PDGF signaling, and amplifies neointima formation in the balloon-injured rat artery. Am J Physiol Heart Circ Physiol 2009; 296:H132-H139.
22. Kubota T, Kubota N, Moroi M, Terauchi Y, Kobayashi T, Kamata K, Suzuki R, Tobe K, Namiki A, Aizawa S, Nagai R, Kadowaki T, Yamaguchi T: Lack of insulin receptor sub-strate-2 causes progressive neointima formation in response to vessel injury. Circulation 2003; 10 7: 3073-3080.
23. Murthy SN, Sukhanov S, McGee J, Greco JA, Chandra S, Delafontaine P, Kadowitz PJ, Mc-Namara DB, Fonseca VA: Insulin glargine reduces carotid intimal hyperplasia after balloon catheter injury in Zucker fatty rats possibly by reduction in oxidative stress. Mol Cell Biochem 2009, E-pub ahead of print.
24. Desouza CV, Gerety M, Hamel FG: Neointi-mal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty rats. Atherosclerosis 2006; 184:283-289.
25. Park SH, Marso SP, Zhou Z, Foroudi F, Topol EJ, Lincoff AM: Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus. Circulation 2001; 104:815-819.
26. Brown AT, Smith TP, Cruz CP, Poirier LA, Simmons D, Williams DK, Wang Y, Eidt JF, Moursi MM: Intimal hyperplasia following carotid endarterectomy in an insulin-resistant rat model. Metabolism 2003; 52:834-839.
27. Lee MK, Miles PD, Khoursheed M, Gao KM, Moossa AR, Olefsky JM: Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 1994; 43: 14 3 5-1439.
28. Thresher JS, Podolin DA, Wei Y, Mazzeo RS, Pagliassotti MJ: Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance. Am J Physiol Regul Integr Comp Physiol 2000; 279:R1334-R1340.
29. Koyama K, Chen G, Lee Y, Unger RH: Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsu-linemia of obesity. Am J Physiol 1997; 273: E708-E713.
30. Pagliassotti MJ, Prach PA, Koppenhafer TA, Pan DA: Changes in insulin action, triglyc-erides, and lipid composition during sucrose feeding in rats. Am J Physiol 1996; 271: R1319-R1326.
31. Kazumi T, Vranic M, Steiner G: Triglyceride kinetics: effects of dietary glucose, sucrose, or fructose alone or with hyperinsulinemia. Am J Physiol 1986; 250:E325-E330.