MR characterisation of dysplastic nodules and hepatocarcinoma in the cirrhotic liver with hepatospecific superparamagnetic contrast agents: Pathological correlation in explanted livers;Caratterizzazione RM dei noduli displasici e dell'epatocarcinoma nel fegato cirrotico con mezzi di contrasto superparamagnetici epatospecifici: Correlazione anatomo-patologica nei fegati espiantati

Radiologia Medica

Volumn 114, Issue 8, 2009, Pages 1267-1282

  Macarini, L ^a   Milillo, P ^a,c   Cascavilla, A ^a   Scalzo, G ^a   Stoppino, L ^a   Vinci, R ^a   Moretti, G ^b   Ettorre, G ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b S Giacomo Hospital   (Italy)

^c Via F Chieffi 40 ^*  (Italy)

Author keywords

Dysplastic nodules; Hepatocellular carcinoma; Magnetic resonance imaging; SPIO

Indexed keywords

CONTRAST MEDIUM; DIAGNOSTIC AGENT; MAGNETITE; SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; CELL TRANSFORMATION; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; LIVER TUMOR; MALE; MIDDLE AGED; NODULAR HYPERPLASIA; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PREDICTION AND FORECASTING; SENSITIVITY AND SPECIFICITY;

CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; EARLY DETECTION OF CANCER; FEMALE; FERROSOFERRIC OXIDE; FOCAL NODULAR HYPERPLASIA; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY;

EID: 75949126513     PISSN: 00338362     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11547-009-0464-9     Document Type: Article

References (45)

1. Brown JJ, Naylor MJ, Yagan N (1997) Imaging of hepatic cirrhosis. Radiology 202:1-16
2. El-Serag HB, Mason AC (1999) Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 340:745-750
3. Colombo M, de Franchis R, Del Ninno E et al (1991) Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 325:675-680
4. Lencioni R, Bartolozzi C, Caramella D, Di Coscio G (1993) Management of adenomatous hyperplastic nodules in the cirrhotic liver: US follow-up or percutaneous alcohol ablation? Abdom Imaging 18:50-55
5. Figueras J, Jaurrieta E, Valls C et al (2000) Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: outcomes based on indicated treatment strategy. J Am Coll Surg 190:580-587
6. Trojan J, Raedle J, Zeuzem S (1998) Serum tests for diagnosis and follow-up of hepatocellular carcinoma after treatment. Digestion 59(suppl):72-74
7. Theise ND, Fiel IM, Hytiroglou P et al (1995) Macroregenerative nodules in cirrhosis are not associated with elevated serum or stainable tissue alphafetoprotein. Liver 15:30-34
8. Bennett GL, Krinsky GA, Abitbol RJ et al (2002) Sonographic detection of hepatocellular carcinoma and dysplastic nodules in cirrhosis: correlation of pretransplantation sonography and liver explant pathology in 200 patients. AJR Am J Roentgenol 179:75-80
9. Szklaruk J, Silverman PM, Charnsangavej C (2003) Imaging in diagnosis, staging, treatment, and surveillance of hepatocellular carcinoma. AJR Am J Roentgenol 180:441-454
10. Lim JH, Kim CK, Lee WJ et al (2000) Detection of hepatocellular carcinomas and dysplastic nodules in cirrhotic livers: accuracy of helical CT in transplant patients. AJR Am J Roentgenol 175:693-698
11. Pauleit D, Textor J, Bachmann R et al (2002) Hepatocellular carcinoma: detection with gadolinium- and ferumoxides-enhanced MR imaging of the liver. Radiology 222:73-80
12. Krinsky GA, Lee VS (2000) MR imaging of cirrhotic nodules. Abdom Imaging 25:471-482
13. Hagspiel KD, Neidl KFW, Eichenberger AC et al (1995) Detection of liver metastases: comparison of superparamagnetic iron oxide-enhanced and unenhanced MR imaging at 1.5T with dynamic CT, intraoperative US and percutaneous US. Radiology 196:471-478
14. Seneterre E, Taourel P, Bouvier Y et al (1996) Detection of hepatic metastasis: ferumoxidesenhanced MR imaging versus unenhanced MR imaging ad CT during arterialportography. Radiology 200:785-792
15. Sugihara S, Suto Y, Kamba M, Ogawa T (2001) Comparison of various techniques of iron oxide-enhanced breath-hold MR imaging of hepatocellular carcinoma. Clin Imaging 25:104-109
16. Suto Y, Shimatani Y (1995) Dual contrast magnetic resonance imaging with combined used of positive and negative contrast agent in human hepatocellular carcinoma. BJR 68:116-120
17. Kim SH, Choi D, Kim SH et al (2005) Ferucarbotran-enhanced MRI versus triple phase MDCT for the preoperative detection of hepatocelular carcinoma. AJR Am J Roentgenol 184:1069-1076
18. Hayashi M, Matsui O, Ueda K et al (2002) Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 225:143-149
19. Matsui O, Ueda K, Kobayashi S et al (2002) Intra- and perinodular hemodynamics of hepatocellular carcinoma: CT observation during intra-arterial contrast injection. Abdom Imaging 27:147-156
20. Efremidis SC, Hytiroglou P (2002) The multistep process of hepatocarcinogenesis in cirrhosis with imaging correlation. Eur Radiol 12:753-764
21. International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983-993
22. Liver Cancer Study Group of Japan (1992) The general rules for the clinical and pathological study of primary liver cancer. Kanehara Publishers, Tokyo
23. Iannaccone R, Laghi A,Catalano C et al (2004) Lesioni focali nel paziente cirrotico: valutazione con TC spirale multistrato. Radiol Med 107:304-316
24. Earls JP, Theise ND, Weinreb JC et al (1996) Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology 201:207-214
25. Lim JH, Choi BI (2002) Dysplastic nodules in liver cirrhosis: imaging. Abdom Imaging 27:117-128
26. Macarini L, Marini S, Murrone M (2004) Alterazioni della captazione e della distribuzione epatica dei mezzi di contrasto superparamagnetici organospecifici per risonanza magnetica. Rilievo clinico e classificazione sulla base del meccanismo patogenetico. Radiol Med 108:159-171
27. Catalano O, Nunziata A, Lobianco R, Siani A (2005) Real-time harmonic contrast material-specific US of focal liver lesions. Radiographics 25:333-349
28. Valls C, Cos M, Figueras J et al (2004) Pretransplantation diagnosis and staging of hepatocellular carcinoma in patients with cirrhosis: value of dualphase helical CT. AJR Am J Roentgenol 182:1011-1017
29. Hayashi M, Matsui O, Ueda K et al (1999) Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 172:969-976
30. Krinsky GA, Lee VS, Theise ND (2000) Focal lesions in the cirrhotic liver: high resolution ex vivo MRI with pathologic correlation. J Comput Assist Tomogr 24:189-196
31. Matsuo M, Kanematsu M, Itoh K et al (2001) Detection of malignant hepatic tumors: comparison of gadolinium and ferumoxides-enhanced MR imaging. AJR Am J Roentgenol 177:637-643
32. Kim MJ, Kim JH, Chung JJ et al (2003) Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging. Radiology 228:719-726
33. Krinsky G A, Lee VS, Theise ND et al (2001) Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnosis with MR imaging and explantation correlation. Radiology 219:445-454
34. Di Cesare E, Cariello G, Barile A et al (2000) Risonanza magnetica delle lesioni focali epatiche: valutazione contrastografica dinamica con gadolinio vs mezzo di contrasto epatospecifico reticolo-endoteliale. Radiol Med 100:245-250
35. Paley MR, Mergo PJ, Torres GM, Ros PR (2000) Characterization of focal hepatic lesions with ferumoxides.enhanced T2-weighted MR imaging. AJR Am J Roentgenol 175:159-163
36. Stark DD, Weissleder R, Elizondo G et al (1988) Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 162:297-301 (Pubitemid 18184446)
37. Kang BK, Lim JH, Kim SH et al (2003) Preoperative depiction of hepatocellular carcinoma: ferumoxides-enhanced MR imaging versus triple-phase helical CT. Radiology 226:79-85
38. Macarini L, Marini S, Milillo P et al (2006) RM epatica a doppio contrasto (RM-DC) nello studio del fegato cirrotico: utilità della somministrazione di Gd-DTPA come completamento di esami in cui siano presenti alterazioni di captazione e distribuzione epatiche (ACDE) del Mdc SPIO e nell'identificazione e caratterizzazione delle lesioni focali. Radiol Med 111:1087-1102
39. Tanaka M, Nakashima O, Wada Y et al (1996) Pathomorphological study of Kupffer cells inn hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology 24:807-812
40. Lim JH, Choi D, Cho SK et al (2001) Conspicuity of hepatocellular nodular lesion in cirrhotic liver at ferumoxidesenhanced MR imaging: importance of Kupffer cell number. Radiology 669-676
41. Tang Y, Yaamashita Y, Arakaawa A et al (1999) Detection of hepatocellular carcinoma arising in cirrhotic livers: comparision of gadolinium and ferumoxides-enhanced MR imaging. AJR Am J Roentgenol 172:1547-1554
42. Clement O, Frija G, Chambon C et al (1991) Liver tumors in cirrhosis: experimental study with SPIOenhanced and irone oxide-enhanced MR imaging. Radiology 180:31-36
43. Yamashita Y, Yamamoto H, Hirai A et al (1996) MR imaging enhancement with superparamagnetic iron oxide in chronic liver disease: influente of the liver dysfunction and parenchymal pathology. Abdom Imaging 21:318-323
44. Lucidarme O, Baleston F, Caldi M et al (2002) Non-invasive detection of liver fibrosis: is superparamagnetic iron oxide particle-enhanced MR imaging a contributive technique. Eur Radiol 13:467-474
45. Tonan T, Fujimoto K, Azuma S et al (2007) Evaluation of small (<2 cm) dysplastic nodules and well differentiated hepatocellular carcinomas with ferucarbotranenhanced MRI in a 1.0-T MRI unit: Utility of T2*-weighted gradient echo sequences with an intermediate echo-time. Eur J Radiol 64: 133-139