Evaluation of small (≤2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: Utility of T2*-weighted gradient echo sequences with an intermediate-echo time

European Journal of Radiology

Volumn 64, Issue 1, 2007, Pages 133-139

  Tonan, Tatsuyuki ^a   Fujimoto, Kiminori ^a   Azuma, Sanae ^a   Ono, Noriyuki ^b   Matsushita, Sunao ^b   Kojiro, Masamichi ^a   Hayabuchi, Naofumi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Chikugo City Hospital   (Japan)

Author keywords

Dysplastic nodule; Ferucarbotran; Kupffer cell; Superparamagnetic iron oxide; T2* weighted gradient echo sequence; Well differentiated hepatocellular carcinoma

Indexed keywords

DYSPLASTIC NODULES; SUPERPARAMAGNETIC IRON OXIDE; WELL-DIFFERENTIATED HEPATOCELLULAR CARCINOMA;

IRON OXIDES; MAGNETIC RESONANCE IMAGING; ONCOLOGY; SIGNAL TO NOISE RATIO; SUPERPARAMAGNETISM;

RADIOLOGY;

CONTRAST MEDIUM; FERUCARBOTRAN; SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; IRON; OXIDE;

ADULT; AGED; ARTICLE; CALCULATION; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER NODULE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RANK SUM TEST; SIGNAL NOISE RATIO; ECHO PLANAR IMAGING; IMAGE ENHANCEMENT; LUNG TUMOR; METHODOLOGY; MIDDLE AGED; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; ECHO-PLANAR IMAGING; FEMALE; HUMANS; IMAGE ENHANCEMENT; IRON; LUNG NEOPLASMS; MALE; MIDDLE AGED; OXIDES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 34548697278     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2007.02.023     Document Type: Article

References (15)

1. Takayama T., Makuuchi M., Hirohashi S., et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 336 (1990) 1150-1153
2. Sakamoto M., Hirohashi S., and Shimasato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 22 (1991) 172-178
3. Ferrell L., Wright T., Lake J., et al. Incidence and diagnostic features of macroregenerative nodules vs. small hepatocellular carcinoma in cirrhotic livers. Hepatology 16 (1992) 1372-1381
4. Ishikawa M., Yogita S., Miiyake H., et al. Differential diagnosis of small hepatocellular carcinoma and borderline lesions and therapeutic strategy. Hepatogastroenterology 49 (2002) 1591-1596
5. Asahina Y., Izumi N., Uchihara M., et al. Assessment of Kupffer cells by ferumoxides-enhanced MR imaging is beneficial for diagnosis of hepatocellular carcinoma: comparison of pathological diagnosis and perfusion patterns assessed by CT hepatic arteriography and CT arterioportography. Hepatol Res 27 (2003) 196-204
6. Lim J.H., Choi D., Cho S.K., et al. Conspicuity of hepatocellular nodular lesions in cirrhotic livers at ferumoxides-enhanced MR imaging: importance of Kupffer cell number. Radiology 220 (2001) 669-676
7. Yamamoto H., Yamashita Y., Yoshimatsu S., et al. Hepatocellular carcinoma in cirrhotic livers: detection with enhanced and iron oxide-enhanced MR imaging. Radiology 195 (1995) 106-112
8. Imai Y., Murakami T., Yoshida S., et al. Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading. Hepatology 32 (2000) 205-212
9. Kato H., Kanematsu M., Kondou H., et al. Ferumoxide-enhanced MR imaging of hepatocellular carcinoma: correlation with histologic tumor grade and tumor vascularity. J Magn Reson Imaging 19 (2004) 76-81
10. Terminology of nodular hepatocellular lesions: International Working Party. Hepatology 1995; 22:983-93.
11. Tanaka M., Nakashima O., Wada Y., et al. Pathomorphological study of Kupffer cells in hepatocellular carcinoma and hyperplastic nodular lesions in the liver. Hepatology 24 (1996) 807-812
12. Paley M.R., Mergo P.J., Torres G.M., et al. Characterization of focal hepatic lesions with ferumoxides-enhanced T2-weighted MR imaging. Am J Roentgenol 175 (2000) 159-163
13. Vogl T.J., Hammersting R., Schwarz W., et al. Superparamagnetic iron oxide-enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions. Radiology 198 (1996) 881-887
14. Matsuda H., Saitoh K., Saguchi T., et al. A utility of AMI-25 enhanced MRI for HCC. Jpn J Clin Radiol 38 (1993) 551-557
15. Ward J., Guthrie J.A., Wilson D., et al. Colorectal hepatic metastases: detection with SPIO-enhanced breath-hold MR imaging comparison of optimized sequences. Radiology 228 (2003) 709-718