Bone Morphogenetic Proteins in Craniomaxillofacial Surgery

Oral and Maxillofacial Surgery Clinics of North America

Volumn 22, Issue 1, 2010, Pages 17-31

  Davies, Sarah D ^a   Ochs, Mark W ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Bone morphogenetic proteins; Craniomaxillofacial surgery; Facial skeleton; Grafting

Indexed keywords

BONE MORPHOGENETIC PROTEIN; DRUG CARRIER; RECOMBINANT PROTEIN;

ANIMAL; BONE DEVELOPMENT; BONE DISEASE; BONE REGENERATION; BONE TRANSPLANTATION; FACIAL BONE; HUMAN; JAW DISEASE; METHODOLOGY; ORAL SURGERY; PHYSIOLOGY; REVIEW; SKULL;

ALVEOLAR RIDGE AUGMENTATION; ANIMALS; BONE DISEASES; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE TRANSPLANTATION; DRUG CARRIERS; FACIAL BONES; HUMANS; JAW DISEASES; OSTEOGENESIS; RECOMBINANT PROTEINS; SKULL;

EID: 75949116518     PISSN: 10423699     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coms.2009.10.007     Document Type: Review

References (47)

1. Wozney J.M. Overview of bone morphogenetic proteins. Spine 27 16 Suppl 1 (2002) S2-S8
2. Kalfas I.H. Principles of bone healing. Neurosurg Focus 10 4 (2001) E1
3. Smith D.M., Cooper M., Mooney M.P., et al. Bone morphogenetic protein 2 therapy for craniofacial surgery. J Craniofac Surg 19 5 (2008) 1244-1259
4. Wikesjo U.M., Sorensen R.G., and Wozney J.M. Augmentation of alveolar bone and dental implant osseointegration: clinical implications of studies with rhBMP-2. J Bone Joint Surg Am 83 Suppl 1(Pt 2) (2001) S136-S145
5. Urist M.R. Bone: formation by autoinduction. Science 150 698 (1965) 893-899
6. Geiger M., Li R.H., and Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 55 12 (2003) 1613-1629
7. Li R.H., and Wozney J.M. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol 19 7 (2001) 255-265
8. Vaibhav B., Nilesh P., Vikram S., et al. Bone morphogenic protein and its application in trauma cases: a current concept update. Injury 38 11 (2007) 1227-1235
9. Vukicevic S., and Sampath K.T. Bone morphogenetic proteins: regeneration of bone and beyond. Boston (2004), Birkhauser Verlag, Basel p. xi, 310
10. Termaat M.F., Den Boer F.C., Bakker F.C., et al. Bone morphogenetic proteins. Development and clinical efficacy in the treatment of fractures and bone defects. J Bone Joint Surg Am 87 6 (2005) 1367-1378
11. Lane J.M. Bone morphogenic protein science and studies. J Orthop Trauma 19 Suppl 10 (2005) S17-S22
12. Kang Q., Sun M.H., Cheng H., et al. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 11 17 (2004) 1312-1320
13. Hollinger J.O., Uludag H., and Winn S.R. Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliv Rev 31 3 (1998) 303-318
14. Poynton A.R., and Lane J.M. Safety profile for the clinical use of bone morphogenetic proteins in the spine. Spine 27 16 Suppl 1 (2002) S40-S48
15. Boyne P.J., Lilly L.C., Marx R.E., et al. De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg 63 12 (2005) 1693-1707
16. Orui H., Imaizumi S., Ogino T., et al. Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report. J Orthop Sci 5 6 (2000) 600-604
17. Friedlaender G.E., Perry C.R., Cole J.D., et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 83-A Suppl 1(Pt 2) (2001) S151-S158
18. Paramore C.G., Lauryssen C., Rauzzino M.J., et al. The safety of OP-1 for lumbar fusion with decompression-a canine study. Neurosurgery 44 5 (1999) 1151-1155 [discussion: 1155-6]
19. Howell T.H., Fiorellini J., Jones A., et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restorative Dent 17 2 (1997) 124-139
20. Cochran D.L., Jones A.A., Lilly L.C., et al. Evaluation of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans. J Periodontol 71 8 (2000) 1241-1257
21. Fiorellini J.P., Howell T.H., Cochran D., et al. Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. J Periodontol 76 4 (2005) 605-613
22. Kirker-Head C.A., Nevins M., Palmer R., et al. A new animal model for maxillary sinus floor augmentation: evaluation parameters. Int J Oral Maxillofac Implants 12 3 (1997) 403-411
23. Hanisch O., Tatakis D.N., Rohrer M.D., et al. Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates. Int J Oral Maxillofac Implants 12 6 (1997) 785-792
24. Wada K., Nimi A., Watanabe K., et al. Maxillary sinus floor augmentation in rabbits: a comparative histologic-histomorphometric study between rhBMP-2 and autogenous bone. Int J Periodontics Restorative Dent 21 3 (2001) 252-263
25. Boyne P.J., Marx R.E., Nevins M., et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent 17 1 (1997) 11-25
26. Li J.Z., Li H., Hankins G.R., et al. Different osteogenic potentials of recombinant human BMP-6 adeno-associated virus and adenovirus in two rat strains. Tissue Eng 12 2 (2006) 209-219
27. Vukicevic S., and Sampath K.T. Bone morphogenetic proteins: from local to systemic therapeutics. Boston (2008), Birkhäuser, Basel p. xi, 343
28. Sigurdsson T.J., Nygaard L., Tatakis D.N., et al. Periodontal repair indogs: evaluation of rhBMP-2 carriers. Int J Periodontics Restorative Dent 16 6 (1996) 524-527
29. Nevins M., Kirker-Head M.A., Nevins M., et al. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodontics Restorative Dent 16 1 (1996) 8-19
30. Sigurdsson T.J., Fu E., Tatakis D.N., et al. Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clin Oral Implants Res 8 5 (1997) 367-374
31. Sigurdsson T.J., Nguyen S., and Wikesjo U.M. Alveolar ridge augmentation with rhBMP-2 and bone-to-implant contact in induced bone. Int J Periodontics Restorative Dent 21 5 (2001) 461-473
32. Hanisch O., Tatakis D.N., Boskovic M.M., et al. Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2. Int J Oral Maxillofac Implants 12 5 (1997) 604-610
33. Wikesjo U.M., Kean C.J., and Zimmerman G.J. Periodontal repair in dogs: supraalveolar defect models for evaluation of safety and efficacy of periodontal reconstructive therapy. J Periodontol 65 12 (1994) 1151-1157
34. Carstens M.H., Chin M., and Li X.J. In situ osteogenesis: regeneration of 10-cm mandibular defect in porcine model using recombinant human bone morphogenetic protein-2 (rhBMP-2) and Helistat absorbable collagen sponge. J Craniofac Surg 16 6 (2005) 1033-1042
35. Boyne P.J. Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects. J Bone Joint Surg Am 83 Suppl 1(Pt 2) (2001) S146-S150
36. Toriumi D.M., Kotler H.S., Luxenberg D.P., et al. Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation. Arch Otolaryngol Head Neck Surg 117 10 (1991) 1101-1112
37. Boyne P.J. Animal studies of application of rhBMP-2 in maxillofacial reconstruction. Bone 19 Suppl 1 (1996) 83S-92S
38. Boyne P.J., Nakamura A., and Shabahang S. Evaluation of the long-term effect of function on rhBMP-2 regenerated hemimandibulectomy defects. Br J Oral Maxillofac Surg 37 5 (1999) 344-352
39. Terheyden H., Knak C., Jepsen S., et al. Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: an experimental study in miniature pigs. Part I: prefabrication. Int J Oral Maxillofac Surg 30 5 (2001) 373-379
40. Terheyden H., Jepsen S., and Rueger D.R. Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: a preliminary study. Int J Oral Maxillofac Surg 28 6 (1999) 461-463
41. Chin M., Ng T., Tom W.K., et al. Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg 16 5 (2005) 778-789
42. Boyne P.J., Nath R., and Nakamura A. Human recombinant BMP-2 in osseous reconstruction of simulated cleft palate defects. Br J Oral Maxillofac Surg 36 2 (1998) 84-90
43. Dickinson B.P., Ashley R.K., Wasson K.L., et al. Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects. Plast Reconstr Surg 121 1 (2008) 209-217
44. Sheehan J.P., Sheehan J.M., Seeherman H., et al. The safety and utility of recombinant human bone morphogenetic protein-2 for cranial procedures in a nonhuman primate model. J Neurosurg 98 1 (2003) 125-130
45. Springer I.N., Yahya A., Solveig K., et al. Bone graft versus BMP-7 in a critical size defect-cranioplasty in a growing infant model. Bone 37 4 (2005) 563-569
46. Smith D.M., Afifi A.M., Cooper G.M., et al. BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty. J Craniofac Surg 19 5 (2008) 1315-1322
47. Carstens M.H., Chin M., Ng T., et al. Reconstruction of #7 facial cleft with distraction-assisted in situ osteogenesis (DISO): role of recombinant human bone morphogenetic protein-2 with Helistat-activated collagen implant. J Craniofac Surg 16 6 (2005) 1023-1032