Vitamin e does not slow the progression of hypercholesterolemic atherosclerosis

International Journal of Angiology

Volumn 18, Issue 2, 2009, Pages 89-95

  Prasad, Kailash ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Aortic antioxidant reserve; Atherosclerosis; Hypercholesterolemia; Slowing of progression of atherosclerosis; White blood cell chemiluminescence

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYGEN RADICAL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESERVE; AORTA; AORTA INTIMA; ARTICLE; ATHEROSCLEROSIS; CHEMOLUMINESCENCE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG TREATMENT FAILURE; EXPERIMENTAL RABBIT; FEMALE; HYPERCHOLESTEROLEMIA; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS; HYPERLIPIDEMIA; LEUKOCYTE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 75949103486     PISSN: 10611711     EISSN: 16155939     Source Type: Journal    
DOI: 10.1055/s-0031-1278333     Document Type: Article

References (42)

1. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: Effect of vitamin E. Am Heart J 1993;125:958-73. (Pubitemid 23117326)
2. Prasad K, Kalra J, Lee P. Oxygen free radicals as a mechanism of hypercholesterolemic atherosclerosis: Effects of probucol. Int J Angiol 1994;3:100-12.
3. Steinberg D. Antioxidants in the prevention of human atherosclerosis. Circulation 1992;85:2337-44.
4. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 1999;99:1355-62. (Pubitemid 29129922)
5. Prasad K, Lee P. Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. Atherosclerosis 2007;192:313-22. (Pubitemid 46726333)
6. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-6. (Pubitemid 23143847)
7. Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444-9. (Pubitemid 23143846)
8. Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996;334:1156-62. (Pubitemid 26137974)
9. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-6. (Pubitemid 26091640)
10. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: The Established Population for Epidemiologic Studies of the Elderly. Am J Clin Nutr 1996;64:190-6. (Pubitemid 26250838)
11. Salonen JT, Nyyssönen K, Salonen R, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: A randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000;248:377-86.
12. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet 1999;354:447-55.
13. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial. Lancet 2002;360:23-33.
14. de Gaetano G. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomised trial in general practice. Lancet 2001;357:89-95.
15. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:154-60. (Pubitemid 30051646)
16. Hodis HN, Mack WJ, LaBree L, et al; VEAPS Research Group. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: The Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation 2002;106:1453-9.
17. Cyrus T, Yao Y, Rokach J, Tang LX, Praticò D. Vitamin E reduces progression of atherosclerosis in low-density lipoprotein receptordeficient mice with established vascular lesions. Circulation 2003;107:521-3. (Pubitemid 36176798)
18. Averill MM, Bennett BJ, Rattazzi M, et al. Neither antioxidants nor genistein inhibit the progression of established atherosclerotic lesions in older apoE deficient mice. Atherosclerosis 2009;203:82-8.
19. Prasad K. Vitamin E does not regress hypercholesterolemic atherosclerosis. J Cardiovasc Pharmacol Ther 2009. (In press)
20. Kapoor R, Prasad K. Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: Effect of SOD and catalase. Circ Shock 1994;43:79-94. (Pubitemid 24331183)
21. Lee P, Prasad K. Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by cyclooxygenase inhibitors. Int J Angiol 2003;12:13-23. (Pubitemid 37153422)
22. Holman RL, McGill HC Jr, Strong JP, Geer JC. Techniques for studying atherosclerotic lesions. Lab Invest 1958;7:42-7.
23. Gornall AG, Bardawill CJ, David MM. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949;177:751-66.
24. Kesaniemi YA, Grundy SM. Lack of effect of tocopherol on plasma lipids and lipoproteins in man. Am J Clin Nutr 1982;36:224-8. (Pubitemid 12068682)
25. Lonn EM, Yusuf S, Dzavik V, et al. Effects of ramipril and vitamin E on atherosclerosis: The study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE). Circulation 2001;103:919-25. (Pubitemid 32183795)
26. Prasad K. A study on regression of hypercholesterolemic atherosclerosis in rabbits by flax lignan complex. J Cardiovasc Pharmacol Ther 2007;12:304-13. (Pubitemid 350264697)
27. Prasad K, Lee P, Mantha SV, Kalra J, Prasad M, Gupta JB. Detection of ischemia-reperfusion cardiac injury by cardiac muscle chemiluminescence. Mol Cell Biochem 1992;115:49-58.
28. Prasad K. Flax lignan complex slows down the progression of atherosclerosis in hyperlipidemic rabbits. J Cardiovasc Pharmacol Ther 2009;14:38-48.
29. Rao PS, Cohen MV, Mueller HS. Production of free radicals and lipid peroxides in early experimental myocardial ischemia. J Mol Cell Cardiol 1983;15:713-6. (Pubitemid 13019802)
30. Mantha SV, Prasad M, Kalra J, Prasad K. Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits. Atherosclerosis 1993;101:135-44. (Pubitemid 23214226)
31. Warren JS, Ward PA. Oxidative injury to the vascular endothelium. Am J Med Sci 1986;292:97-103.
32. Martin A, Foxall T, Blumberg JB, Meydani M. Vitamin E inhibits low density lipoprotein-induced adhesion of monocytes to human aortic endothelial cells in vitro. Arterioscler Thromb Vasc Biol 1997;17:429-36. (Pubitemid 27133131)
33. Chiu JJ, Wumg BS, Shyy JY, Hsieh HJ, Wang DL. Reactive oxygen species are involved in shear stress-induced intercellular adhesion molecule-1 expression in endothelial cells. Arterioscler Thromb Vasc Biol 1997;17:3570-7. (Pubitemid 28028570)
34. Cushing SD, Berliner JA, Valente AJ, et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA 1990;87:5134-8.
35. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 1996;98:2572-9. (Pubitemid 26415078)
36. Böger RH, Bode-Böger SM, Brandes RP, et al. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: Comparison with lovastatin. Circulation 1997;96:1282-90. (Pubitemid 27344234)
37. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-5.
38. Böger RH, Bode-Böger SM, Mugge A, et al. Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis 1995;117:273-84.
39. Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 1992;90:1168-72.
40. Burton GW, Ingold KU. Vitamin E: Applications of the principles of physical organic chemistry to the explanation of its structure and function. Acc Chem Res 1986;19:194-210.
41. Bowry VW, Ingold KU, Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem J 1992;288:341-4.
42. Doba T, Burton GW, Ingold KU. Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim Biophys Acta 1985;835:298-303. (Pubitemid 15066069)