Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation

Schizophrenia Research

Volumn 117, Issue 1, 2010, Pages 42-51

  Kim, Miyoung A ^a,g   Tura, Emanuela ^b,g   Potkin, Steven G ^a,g   Fallon, James H ^a,g   Manoach, Dara S ^c,d,g   Calhoun, Vince D ^e,f,g   Turner, Jessica A ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MIND RESEARCH NETWORK   (United States)

^f UNIVERSITY OF NEW MEXICO   (United States)

^g NONE

Author keywords

Functional magnetic resonance imaging; Multivariate analysis; Neurocircuitry; Partial least squares; Schizophrenia; Working memory

Indexed keywords

ADULT; ARTICLE; BASAL GANGLION; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; EVOKED CORTICAL RESPONSE; FEMALE; FRONTAL LOBE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MEMORY CONSOLIDATION; MOTOR CORTEX; NERVE CELL NETWORK; OCCIPITAL LOBE; OXYGEN BLOOD LEVEL; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; RESPONSE TIME; SCHIZOPHRENIA; TEMPORAL LOBE; WORKING MEMORY;

ADULT; CEREBRAL CORTEX; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; NERVE NET; NEUROPSYCHOLOGICAL TESTS; PARIETAL LOBE; PREFRONTAL CORTEX; REACTION TIME; RECOGNITION (PSYCHOLOGY); SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 75949098490     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2009.12.014     Document Type: Article

References (47)

1. Andreasen N.C. Modified Scale for the Assessment of Negative Symptoms (SANS) (1984), University of Iowa, Iowa City, IA
2. Andreasen N.C. Scale for the Assessment of Positive Symptoms (SAPS) (1984), University of Iowa, Iowa City, IA
3. Barch D.M., Sheline Y.I., Csernansky J.G., and Snyder A.Z. Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression. Biol. Psychiatry 53 5 (2003) 376-384
4. Braver T.S., Cohen J.D., Nystrom L.E., Jonides J., Smith E.E., et al. A parametric study of prefrontal cortex involvement in human working memory. NeuroImage 5 1 (1997) 49-62
5. Brown G.G., McCarthy G., Bischoff-Grethe A., Ozyurt B., Greve D., et al. Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophr. Bull. 35 1 (2009) 32-46
6. Cairo T.A., Liddle P.F., Woodward T.S., and Ngan E.T. The influence of working memory load on phase specific patterns of cortical activity. Brain Res. 21 3 (2004) 377-387
7. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex 10 11 (2000) 1078-1092
8. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am. J. Psychiatry 160 4 (2003) 709-719
9. Callicott J.H., Ramsey N.F., Tallent K., Bertolino A., Knable M.B., et al. Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 18 3 (1998) 186-196
10. Cannon T.D., Glahn D.C., Kim J., Van Erp T.G., Karlsgodt K., et al. Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Arch. Gen. Psychiatry 62 10 (2005) 1071-1080
11. Carter C.S., Perlstein W., Ganguli R., Brar J., Mintun M., et al. Functional hypofrontality and working memory dysfunction in schizophrenia. Am. J. Psychiatry 155 9 (1998) 1285-1287
12. Dronkers N.F., Wilkins D.P., Van Valin Jr. R.D., Redfern B.B., and Jaeger J.J. Lesion analysis of the brain areas involved in language comprehension. Cognition 92 1-2 (2004) 145-177
13. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV-TR Axis I Disorders. Research Version, Patient Edition. (SCID-I/P) Biometrics Research (2002), New York State Psychiatric Institute, New York
14. Friston K.J., Ashburner J., Frith C.D., Poline J.-B., Heather J.D., and Frackowiak R.S.J. Spatial registration and normalization of images. Hum. Brain Mapp. 2 (1995) 165-189
15. Friston K.J., Holmes A.P., Worsley K.J., Poline J.B., Frith C.D., and Frackowiak R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Hum. Brain Mapp. 2 (1995) 189-210
16. Glahn D.C., Ragland J.D., Abramoff A., Barrett J., Laird A.R., et al. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum. Brain Mapp. 25 1 (2005) 60-69
17. Honey G.D., Bullmore E.T., and Sharma T. Prolonged reaction time to a verbal working memory task predicts increased power of posterior parietal cortical activation. NeuroImage 12 5 (2000) 495-503
18. Honey G.D., Bullmore E.T., and Sharma T. De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia. Schizophr. Res. 53 1-2 (2002) 45-56
19. Jansma J.M., Ramsey N.F., van der Wee N.J., and Kahn R.S. Working memory capacity in schizophrenia: a parametric fMRI study. Schizophr. Res. 68 2-3 (2004) 159-171
20. Johnson M.R., Morris N.A., Astur R.S., Calhoun V.D., Mathalon D.H., et al. A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia. Biol. Psychiatry 60 1 (2006) 11-21
21. Kim D.I., Manoach D.S., Mathalon D.H., Turner J.A., Mannell M., et al. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Human Brain Mapping (2009)
22. Koch K., Wagner G., Nenadic I., Schachtzabel C., Schultz C., et al. Fronto-striatal hypoactivation during correct information retrieval in patients with schizophrenia: an fMRI study. Neuroscience 153 1 (2008) 54-62
23. Koch K., Wagner G., Schultz C., Schachtzabel C., Nenadic I., et al. Altered error-related activity in patients with schizophrenia. Neuropsychologia 47 13 (2009) 2843-2849
24. Kuroki N., Shenton M.E., Salisbury D.F., Hirayasu Y., Onitsuka T., et al. Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. Am. J. Psychiatry 163 12 (2006) 2103-2110
25. Manoach D.S. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr. Res. 60 2-3 (2003) 285-298
26. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol. Psychiatry 48 2 (2000) 99-109
27. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., et al. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol. Psychiatry 45 9 (1999) 1128-1137
28. Manoach D.S., Schlaug G., Siewert B., Darby D.G., Bly B.M., et al. Prefrontal cortex fMRI signal changes are correlated with working memory load. NeuroReport 8 2 (1997) 545-549
29. McIntosh A.R., Bookstein F.L., Haxby J.V., and Grady C.L. Spatial pattern analysis of functional brain images using partial least squares. NeuroImage 3 3 Pt 1 (1996) 143-157
30. McIntosh A.R., and Lobaugh N.J. Partial least squares analysis of neuroimaging data: applications and advances. NeuroImage 23 Suppl 1 (2004) S250-S263
31. Mendrek A., Kiehl K.A., Smith A.M., Irwin D., Forster B.B., et al. Dysfunction of a distributed neural circuitry in schizophrenia patients during a working-memory performance. Psychol. Med. 35 2 (2005) 187-196
32. Onitsuka T., Shenton M.E., Salisbury D.F., Dickey C.C., Kasai K., et al. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am. J. Psychiatry 161 9 (2004) 1603-1611
33. Owen A.M., McMillan K.M., Laird A.R., and Bullmore E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp. 25 1 (2005) 46-59
34. Perlstein W.M., Carter C.S., Noll D.C., and Cohen J.D. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am. J. Psychiatry 158 7 (2001) 1105-1113
35. Perlstein W.M., Dixit N.K., Carter C.S., Noll D.C., and Cohen J.D. Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biol. Psychiatry 53 1 (2003) 25-38
36. Potkin S.G., Turner J.A., Brown G.G., McCarthy G., Greve D.N., et al. Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophr. Bull. 35 1 (2009) 19-31
37. Quintana J., Wong T., Ortiz-Portillo E., Kovalik E., Davidson T., et al. Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations. Biol. Psychiatry 53 1 (2003) 12-24
38. Ragland J.D., Moelter S.T., Bhati M.T., Valdez J.N., Kohler C.G., et al. Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia. Schizophr. Res. 99 1-3 (2008) 312-323
39. Ragland J.D., Yoon J., Minzenberg M.J., and Carter C.S. Neuroimaging of cognitive disability in schizophrenia: search for a pathophysiological mechanism. Int. Rev. Psychiatry 19 4 (2007) 417-427
40. Ramsey N.F., Koning H.A., Welles P., Cahn W., van der Linden J.A., et al. Excessive recruitment of neural systems subserving logical reasoning in schizophrenia. Brain 125 Pt 8 (2002) 1793-1807
41. Rypma B., and D'Esposito M. The roles of prefrontal brain regions in components of working memory: effects of memory load and individual differences. Proc. Natl Acad. Sci. USA 96 11 (1999) 6558-6563
42. Schlosser R.G.M., Koch K., Wagner G., Nenadic I., Roebel M., et al. Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study. Neuropsychologia 46 (2008) 336-347
43. Strand F., Forssberg H., Klingberg T., and Norrelgen F. Phonological working memory with auditory presentation of pseudo-words - an event related fMRI study. Brain Res. 1212 (2008) 48-54
44. Thermenos H.W., Goldstein J.M., Buka S.L., Poldrack R.A., Koch J.K., et al. The effect of working memory performance on functional MRI in schizophrenia. Schizophr. Res. 74 2-3 (2005) 179-194
45. Van Snellenberg J.X., Torres I.J., and Thornton A.E. Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable. Neuropsychology 20 5 (2006) 497-510
46. Walter H., Vasic N., Hose A., Spitzer M., and Wolf R.C. Working memory dysfunction in schizophrenia compared to healthy controls and patients with depression: evidence from event-related fMRI. NeuroImage 35 4 (2007) 1551-1561
47. Wold H. Estimation of principal components and related models by iterative least squares. In: Krishnaiah P.R. (Ed). Multivariate Analysis (1966), Academic Press, New York