2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1388-1395

  Lühr, Susan ^a   Vilches Herrera, Marcelo ^a   Fierro, Angélica ^b,c   Ramsay, Rona R ^d   Edmondson, Dale E ^e   Reyes Parada, Miguel ^b,c   Cassels, Bruce K ^a,c   Iturriaga Vásquez, Patricio ^a,c  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^c Iniciativa Cientifica Milenio Santiago   (Chile)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

^e EMORY UNIVERSITY   (United States)

Author keywords

Amphetamine; Arylthiomorpholine derivatives; Docking; Human and rat MAO; MAO inhibitors; Monoamine oxidase

Indexed keywords

2 (4' BENZYLOXYPHENYL)THIOMORPHOLIN 5 ONE; 2 (4' BENZYLOXYPHENYL)THIOMORPHOLINE OXALATE; 2 (4' BUTOXYPHENYL)THIOMORPHOLIN 5 ONE; 2 (4' BUTOXYPHENYL)THIOMORPHOLINE OXALATE; 2 (4' ETHOXYPHENYL)THIOMORPHOLIN 5 ONE; 2 (4' ETHOXYPHENYL)THIOMORPHOLINE OXALATE; 2 (4' METHOXYPHENYL)THIOMORPHOLIN 5 ONE; 2 (4' METHOXYPHENYL)THIOMORPHOLINE OXALATE; 2 (4' PROPOXYPHENYL)THIOMORPHOLIN 5 ONE; 2 (4' PROPOXYPHENYL)THIOMORPHOLINE OXALATE; 2 PHENYLTHIOMORPHOLIN 5 ONE; 2 PHENYLTHIOMORPHOLINE OXALATE; AMINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; NITROGEN; PHENETHYLAMINE; THIOMORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; METHYLATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MORPHOLINES; RATS;

RATTUS;

EID: 75849162780     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.029     Document Type: Article

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