Scrambler and yotari disrupt the disabled gene and produce a reeler- like phenotype in mice

Nature

Volumn 389, Issue 6652, 1997, Pages 730-733

  Sheldon, Michael ^a   Rice, Dennis S ^a   D'Arcangelo, Gabriella ^a   Yoneshima, Hiroyuki ^b   Nakajima, Kazunori ^c   Mikoshiba, Katsuhiko ^b,c   Howell, Brian W ^d   Cooper, Jonathan A ^d   Goldowitz, Dan ^e   Curran, Tom ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIKEN TSUKUBA INSTITUTE   (Japan)

^d Fred Hutchinson Cancer Research Center   (United States)

^e UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHOPROTEIN; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; BRAIN DEVELOPMENT; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; BRAIN; CELL ADHESION MOLECULES, NEURONAL; CHROMOSOME MAPPING; CROSSES, GENETIC; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

EID: 0030717493     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/39601     Document Type: Article

References (31)

1. D'Arcangelo, G. et al. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374, 719-723 (1995).
2. Goffinet, A. M. A real gene for reeler. Nature 374, 675-676 (1995).
3. Rakic, P. & Caviness, V. S. J. Cortical development: view from neurological mutants two decades later. Neuron 14, 1101-1104 (1995).
4. D'Arcangelo, G. et al. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J. Neurosci. 17, 23-31 (1997).
5. Hirotsune, S. et al. The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. Nature Genet. 10, 77-83 (1995).
6. Ogawa, M. et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14, 899-912 (1995).
7. Miyata, T. et al. Distribution of the reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogenic antibody CR-50 on normal and reeler mice. J. Camp. Neurol. 372, 215-228 (1996).
8. Miyata, T., Nakajima, K., Mikoshiba, K. & Ogawa, M. Regulation of purkinje cell alignment by reelin as revealed with R-50 antibody. J. Neurosci. 17, 3599-3609 (1997).
9. Sweet, H. O., Bronson, R. T., Johnson, K. R., Cook, S. A. & Davisson, M. T. Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration Mamm. Genome 7, 798-802 (1996).
10. Yoneshima, H. et al. A novel neurological mutation of mouse, yotari, which has reeler-like phenotype but expresses reelin. Neurosci. Res. (in the press).
11. Goldowitz, D. et al. Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin. J. Neurosci. (in the press).
12. Howell, B. W., Gertler, F. B. & Cooper, J. A. Mouse disabled (mDab1): a src binding protein implicated in neuronal development. EMBO J. 16, 121-132 (1997).
13. Gertler, F. B., Bennett, R. L., Clark, M. J. & Hoffmann, F. M. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58, 103-113 (1989).
14. Howell, B. W., Hawkes, R., Soriano, P. & Cooper, J. A. Neuronal position in the developing brain is regulated by mouse disabled-1. Nature 389, 733-737 (1997).
15. Tartaglia, L. A. Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271 (1995).
16. Chua, S. C. Jr et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271, 994-996 (1996).
17. Lee, G. H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635 (1996).
18. Michaud, E. J. et al. Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev, 8, 1463-1472 (1994).
19. Rowe, L. B. et al. Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome 5, 253-274 (1994).
20. Goffinet, A. M. Events governing organization of postmigratory neurons: studies on brain development in normal and reeler mice. Brain Res. Rev. 7, 261-296 (1984).
21. Xu, X. X., Yang, W., Jackowski, S. & Rock, C. O. Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J. Biol. Chem. 270, 14184-14191 (1995).
22. Zhou, M. M. et al. Structure and ligand recognition of the phosphotyrosine binding domain of Sch. Nature 378, 584-592 (1995).
23. Ohshima, T. et al. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl Acad. Sci. USA 93, 11173-11178 (1996).
24. Chae, T. et al. Mice lacking p35, a neuronal activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18, 29-42 (1997).
25. Tang, D. et al. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J. Biol. Chem. 270, 26897-26903 (1995).
26. Del Rio, J. A. et al. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 385, 70-74 (1997).
27. Vaessin, H. et al. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67, 941-953 (1991).
28. Oliver, G. et al. Prox 1, a prospero-related homeobox gene expressed during mouse development Mech. Dev. 44, 3-16 (1993).
29. Gertler, F. B. et al. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev. 9, 521-533 (1995).
30. Gertler, F. B., Niebuhr, K., Reinhard, M., Wehland, J. & Soriano, P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell 87, 227-239 (1996).
31. Dietrich, W. E. et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7, 220-245 (1994).